Visceral adiposity index outperforms conventional anthropometric assessments as predictor of diabetes mellitus in elderly Chinese: a population-based study

Tsou, Meng-Ting; Chang, Yu‐Chen; Hsu, Chen H.; Kuo, Yang-Che; Yun, Chun‐Ho; Huang, Wei-Hsin; Hu, Kuang-Chun; Liu, Chia‐Yuan; Chen, Ying‐Ju; Sung, Kuo‐Tzu; Liu, Chuan-Chuan; Hung, Chung‐Lieh; Kuo, Jen‐Yuan; Chen, Tung-Ying; Hung, Ta‐Chuan; Yeh, Hung‐I

doi:10.1186/s12986-021-00608-6

Cited by 18 publications

(12 citation statements)

References 48 publications

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“…Xia et al [ 11 , 27 ] reported that CVAI is a stronger predictor of prediabetes and diabetes than traditional indexes such as BMI and WC. Similarly, TZou et al [ 28 ] found that CVAI and VAI may serve as potential indicators of diabetes. In addition, some studies reported that VAI is correlated with the risk of macrovascular complications in diabetic population [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 98%

Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population

Kang

et al. 2022

Cardiovasc Diabetol

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Background The association between visceral adiposity index (VAI) and diabetic complications has been reported in cross-sectional studies, while the effect of VAI on complication development remains unclear. This study aims to evaluate the longitudinal association of VAI and Chinese VAI (CVAI) with the incidence of diabetic nephropathy and retinopathy using a Chinese cohort. Methods A total of 8 948 participants with type 2 diabetes from Beijing Health Management Cohort were enrolled during 2013–2014, and followed until December 31, 2019. Nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate; retinopathy was diagnosed using fundus photograph. Results The mean (SD) age was 53.35 (14.66) years, and 6 154 (68.8%) were men. During a median follow-up of 4.82 years, 467 participants developed nephropathy and 90 participants developed retinopathy. One-SD increase in VAI and CVAI levels were significantly associated with an increased risk of nephropathy, and the adjusted hazard ratios (HR) were 1.127 (95% CI 1.050–1.210) and 1.165 (95% CI 1.003–1.353), respectively. On contrary, VAI and CVAI level were not associated with retinopathy after adjusting confounding factors. Conclusion VAI and CVAI are independently associated with the development of nephropathy, but not retinopathy in Chinese adults with diabetes.

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Section: Discussionmentioning

confidence: 98%

Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population

Kang

et al. 2022

Cardiovasc Diabetol

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“…These results had significant heterogeneities as they covered different ethnic populations ( 14 ). Recently, visceral adiposity index (VAI), lipid accumulation product (LAP), and body shape index (ABSI), which are the products of WC, BMI, and blood lipids, have been proposed as reliable indexes of body fat accumulation, and they have been applied to the prediction of diabetes ( 15 – 17 ). With reference to VAI and considering the characteristic of body fat in the Asian population, the Chinese visceral adiposity index (CVAI) has been designed for the Chinese population; this surrogate indicator may be more sensitive than VAI, WC, and BMI to discriminate diabetes ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Visceral adiposity measures are strongly associated with cardiovascular disease among female participants in Southwest China: A population-based prospective study

Wang

Zhao²,

Chen

et al. 2022

Front. Endocrinol.

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Background and aimsControversy remains regarding the prediction effects of different adiposity measure indicators for the risk of cardiovascular disease (CVD). Our study aimed to assess the associations of three traditional anthropometric indicators, namely, waist circumference (WC), waist-to-height ratio (WHtR), and body mass index (BMI) as well as three non-traditional anthropometric indicators, namely, the Chinese visceral adiposity index (CVAI), lipid accumulation product (LAP), and body shape index (ABSI), with the risk of CVD among Southwest Chinese population.MethodsOur study was based on the Guizhou Population Health Cohort Study (GPHCS) conducted from 2010 to 2020. A total of 9,280 participants were recruited from 12 areas in Guizhou Province, China, from November 2010 to December 2012, and followed up for major chronic diseases until December 2020. A total of 7,837 individuals with valid data were included in this analysis. The gender-specific associations of WC, WHtR, BMI, CVAI, LAP, and ABSI with CVD were evaluated using Cox proportional hazards models. Receiver operating characteristic (ROC) curve analysis was used to estimate the prediction powers of different indicators for CVD.ResultsNo association of six indicators with CVD was observed among male participants. Female participants with either WC-based central obesity (HR: 1.82, 95% CI: 1.12–2.97) or WHtR-based central obesity (HR: 1.68, 95% CI: 1.07–2.64) had a higher risk of CVD, after adjusted for age, area, ethnic group, smoking, alcohol drinking, MET, previous history of diabetes, hypertension and dyslipidemia, medication use, and nutraceutical intake. Compared with female participants in the lowest quartile (Q1), those in the highest quartile (Q4) of WHtR (HR: 2.24, 95% CI: 1.17–4.27), CVAI (HR: 3.98, 95% CI: 1.87–8.49), and ABSI (HR: 1.94, 95% CI: 1.06–3.52) had an increased risk for incident CVD. CAVI showed the maximum predictive power of CVD with the biggest AUC of 0.687 (95% CI: 0.654–0.720) compared to other indicators in female participants.ConclusionsVisceral adiposity measures, especially CVAI, are stronger predictive indicators of CVD among female and not male participants in Southwest China. Different anthropometric indexes need to be combined to comprehensively assess health risks.

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“…The findings of our study were in line with the study conducted by Tsou et al that suggested that BMI was significantly associated with DM outcomes when the various anthropometric parameters were compared with P < 0.001 for BMI. However, on compiled analysis, VAI had the maximum AUC (0.66) compared with BMI [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…With WC ( r = 0.97, P < 0.001) in men and women ( r = 0.83, P < 0.001), WC showed an association with DM. However, the AUC suggested that VAI is better than WC [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Visceral Adiposity Index in Type 2 Diabetes Mellitus (DM) and Its Correlation With Microvascular Complications

Hulkoti¹,

Acharya²,

Shukla³

et al. 2022

Cureus

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BackgroundObesity, specifically abdominal obesity, is a major risk factor for diabetes. A strong association has been marked between diabetes and obesity. Many abdominal obesity indices have been established, including waist circumference (WC), BMI, and a new tool, the visceral adiposity index (VAI). However, very limited research highlights the association of these anthropometric parameters and VAI to the various microvascular complications of diabetes mellitus (DM). The objective of this study is to investigate the association of VAI with microvascular complications such as retinopathy, nephropathy, and neuropathy in type 2 DM (T2DM) patients. MethodologyData from Acharya Vinoba Bhave Rural Hospital (AVBRH) was analyzed in this case-control study with a sample size of 250 patients consisting of 125 cases and 125 controls. The cases and controls were age-and gender-matched. BMI and WC were measured in these patients, and the VAI was calculated. These anthropometric parameters were then analyzed to estimate their correlation with the microvascular complications of T2DM. ResultsThe mean age of cases in this study was 58.37 ± 12.08 years and that of controls was 57.61 ± 14.51 years. Anthropometric parameters, namely, BMI, WC, and VAI were raised in cases as compared with controls, and they showed significant statistical relation with diabetes (for BMI, P = 0.003; for WC, P = 0.001 for males and P = 0.002 for females; and for VAI, P = 0.005). A significant correlation was noted in the highdensity lipoprotein (HDL) cholesterol (P = 0.017 for males and P = 0.0004 for females) and triglyceride (TG) levels (P < 0.0001) between cases and controls. On distributing the male and female cases in quartiles, it was observed that with increasing quartiles, VAI increased significantly and was associated with an increased risk of microvascular complications such as retinopathy, nephropathy, and neuropathy. When the anthropometric parameters and VAI were compared with the total microvascular complications and the receiver operating characteristic curve studied, VAI had the maximum AUC (AUC for VAI was 0.826, WC was 0.813, and BMI was 0.806). Univariate analysis of the various microvascular complications showed that WC, BMI, HDL, TGs, and glycated hemoglobin (HbA1c) were all significantly correlated to the microvascular complications in T2DM patients. ConclusionsAs the VAI was significantly raised in T2DM patients and also seen to be significantly associated with microvascular complications, it could be used as a screening tool for T2DM patients.

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Visceral adiposity index outperforms conventional anthropometric assessments as predictor of diabetes mellitus in elderly Chinese: a population-based study

Cited by 18 publications

References 48 publications

Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population

Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population

Visceral adiposity measures are strongly associated with cardiovascular disease among female participants in Southwest China: A population-based prospective study

Visceral Adiposity Index in Type 2 Diabetes Mellitus (DM) and Its Correlation With Microvascular Complications

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