Visceral artery embolization after endoscopic injection of Enteryx for gastroesophageal reflux disease

Abstract

Gastroesophageal reflux disease (GERD) can be difficult to manage medically and may require endoscopic or surgical interventions. The Enteryx procedure was designed to enhance the gastroesophageal barrier function by endoscopic injection of a copolymer into the lower esophageal sphincter. We present a rare case of a patient who was found to have migration of the copolymer into the celiac trunk and bilateral renal arteries during a work-up for persistent intermittent hematuria, which began shortly after Enteryx therapy for GERD.

Updates on Surgical Treatment for Gastroesophageal Reflux Disease

“…75 Adverse events including death led to the removal of Enteryx® from the market. 75,76 Despite these agents showing positive results for the treatment of GERD, there is insufficient data to recommend these agents currently.…”

Advanced Endoscopic Imaging and Interventions in GERD: An Update and Future Directions

“…GERD health-related quality of life heartburn score improvement more than or equal to 50% was much high in Enteryx® group (67%) than sham group (22%) with a rate ratio of 3.05 (95% CI: 1.55–6.33; p < 0.001) ( 49 ). Although Enteryx® decreased PPI use and improved GERD score, it caused serious adverse events like embolization into vascular structures, transluminal injections, and even death leading to recall of this device in 2005 by the FDA ( 50 – 52 ).…”