Visceral fat predominance is associated with non‐alcoholic fatty liver disease in <scp>J</scp>apanese women with metabolic syndrome

Sogabe, Masamichi; Okahisa, Toshiya; Tsujigami, Koji; Fukuno, Hiroshi; Hibino, Shingo; Yamanoi, Akira

doi:10.1111/hepr.12146

Cited by 19 publications

(17 citation statements)

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“…Also in Ordinal logistic regression, BMI was predictor for USG. As well as some explained articles, BMI is predictor of NAFLD severity or significantly higher in the patients with fatty liver (Tables 2 and 3) (26, 40, 41). AST had a prediction role in the severity of disease and U.S grade.…”

Section: Discussionmentioning

confidence: 59%

“…However, it has not been a reliable finding, because AST level changed in many conditions such as systemic disorder (Tables 2 and 3) (28, 30). Nevertheless, in several papers like Purnak T, Sogabe M and Lin YC, AST was a predictor of NAFLD severity and U.S significantly (26, 27, 29). …”

Section: Discussionmentioning

confidence: 95%

“…However, there is controversy about the effect of liver enzymes or lipid profile. Some articles agreed to the effect of liver enzymes on U.S grades and others indicated that only lipid profile or some liver enzymes could affect the process of disease and the grade of U.S (26-30). …”

Section: Introductionmentioning

confidence: 99%

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Correlation of Body Mass Index and Serum Parameters With Ultrasonographic Grade of Fatty Change in Non-alcoholic Fatty Liver Disease

Abangah

Yousefi

Asadollahi

et al. 2014

Iran Red Cres Med J

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Background:Non-alcoholic fatty liver disease (NAFLD) is a common liver disease in the western population and expanding disease in the world. Pathological changes in fatty liver are like alcohol liver damage, which can lead to end-stage liver disease. The prevalence of NAFLD in obese or overweight people is higher than general population, and it seems that people with high Body Mass Index (BMI) or abnormality in some laboratory tests are more susceptible for severe fatty liver and high grade of NAFLD in ultrasonography (U.S).Objectives:This study aimed to evaluate the correlation of BMI and laboratory tests with NAFLD in ultrasonography.Materials and Methods:During a multi-step process, we selected two-hundred and thirteen cases from four hundred and eighteen patients with NAFLD. Laboratory tests performed included: ALT, AST, FBS, Triglyceride and cholesterol levels, hepatitis B surface antigen, hepatitis C antibody, ceruloplasmin, serum iron, TIBC, transferrin saturation, ferritin, AMA, ANA, ANTI LKM1, serum protein electrophoresis, TSH, anti TTG (IgA). BMI and ultrasonography for 213 patients were performed, and then data was analyzed. These parameters and grades of ultrasonography were compared with the values obtained using one way ANOVA. An ordinal logistic regression model was used to estimate the probability of ultrasonography grade. The Statistical Package for the Social Science program (SPSS, version 16.0) was used for data analysis.Results:Two-hundred and thirteen cases including 140 male and 73 female, were studied. In general, 72.3% of patients were overweight and obese. Post-hoc tests showed that only BMI (P < 0.001) and TG (P < 0.011) among variables had statistically significant associations with ultrasonography grade (USG), and ordinal logistic regression model showed that BMI and AST were the best predictors.Discussion:Our results suggest that in patients with NAFLD, BMI and TG are most effective factors in severity of fatty liver disease and ultrasonography grade (USG). On the other hand, BMI as a predictor can be helpful. But, AST has not been a reliable finding, because it changes in many conditions.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 95%

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Correlation of Body Mass Index and Serum Parameters With Ultrasonographic Grade of Fatty Change in Non-alcoholic Fatty Liver Disease

Abangah

Yousefi

Asadollahi

et al. 2014

Iran Red Cres Med J

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“…Gender differences in NAFLD, MS and EO have been recently reported 57 16–18 Sogabe et al 16 17 divided MS into visceral and subcutaneous types, with each having significantly different effects on EO; they also found that the visceral type was predominant among males, while the subcutaneous type was predominant among females. However, until now, there have been no studies regarding the concomitant effects of NAFLD and MS on EO with respect to gender.…”

Section: Introductionmentioning

confidence: 93%

Gender differences in the association of non-alcoholic fatty liver disease and metabolic syndrome with erosive oesophagitis: a cross-sectional study in a Taiwanese population

Hung

Sun

et al. 2016

BMJ Open

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ObjectivesAlthough metabolic syndrome correlates with erosive oesophagitis, few studies have examined the association between non-alcoholic fatty liver disease (NAFLD), associated with obesity and insulin resistance as metabolic syndrome, and erosive oesophagitis. The possible gender differences in risk factors of erosive oesophagitis should be considered. This study aimed to determine the concomitant effects of NAFLD and metabolic syndrome on erosive oesophagitis with respect to gender.Design, setting, participants and outcome measuresThis cross-sectional study, conducted between January 2000 and August 2009, included 12 090 participants from the health examination center of a tertiary hospital. NAFLD was diagnosed according to ultrasonographic findings after excluding participants with excessive alcohol consumption or other liver diseases. Metabolic syndrome was determined using the revised National Cholesterol Education Program Adult Treatment Panel III criteria. Erosive oesophagitis was defined according to the Los Angeles classification by oesophagogastroduodenoscopy.ResultsOn the basis of the oesophagogastroduodenoscopic findings, the prevalence of erosive oesophagitis was 20.1% (n=1427/7110) and 9.9% (n=477/4842) in males and females, respectively. After adjusting for other variables, metabolic syndrome (OR 1.26; 95% CI 1.09 to 1.45) but not NAFLD (OR 1.14; 95% CI 0.98 to 1.30) significantly correlated with erosive oesophagitis in males, while NAFLD (OR 1.50; 95% CI 1.21 to 1.86) but not metabolic syndrome (OR 1.24; 95% CI 0.94 to 1.63) positively correlated with erosive oesophagitis in females.ConclusionsThe detrimental effect on erosive oesophagitis is greater by metabolic syndrome than by NAFLD in males but greater by NAFLD than by metabolic syndrome in females.

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“…Masahiro Kikuchi 1 symptoms resembling those of alcoholic liver dysfunction and the number of patients are increasing along with the increase in that of patients with metabolic syndrome 3) . NAFLD is recognized as an expression type of metabolic syndrome in the liver, so its disease concept has become widely known by the public.…”

Section: Nonalcoholic Steatohepatitis As Fatal Fatty Liver -The Next mentioning

confidence: 99%

Nonalcoholic Steatohepatitis as Fatal Fatty Liver - The next main target in the field of liver disease

Kikuchi

Shiozawa

Yamada

et al. 2013

HEP

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Because of the therapeutic advance in the past 25 years, the incidence of viral hepatitis constituting the largest part of liver disease decreased rapidly, and the main target in the field of liver disease is now shifting from viral hepatitis to fatty liver.Non-alcoholic fatty liver disease (NAFLD) occurs in patients without or with almost no history of alcohol intake. NAFLD is recognized as an expression type of metabolic syndrome in the liver and the patients of NAFLD are also increasing along with the increase of metabolic syndrome. Many of the NAFLD cases are detected by health checkup. However, there are some cases of non-alcoholic steatohepatitis (NASH) that develop liver cirrhosis and /or liver cancer of which the prognosis is poor. So, a follow-up observation and cooperation with specialists in different specialties are necessary in the situation of health checkup. We previously reported some research results about NAFLD/NASH. In this review, we present basic knowledge concerning disease concept, occurrence mechanism, diagnosis and treatment to make better performance at the health evaluation and promotion.

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Visceral fat predominance is associated with non‐alcoholic fatty liver disease in Japanese women with metabolic syndrome

Abstract: Women with V-type MS are more likely to have fatty liver, IGT and liver dysfunction than those with S-type MS. V-type MS is one of the significant predictors for NAFLD in Japanese women with MS.

Cited by 19 publications

References 44 publications

Correlation of Body Mass Index and Serum Parameters With Ultrasonographic Grade of Fatty Change in Non-alcoholic Fatty Liver Disease

Correlation of Body Mass Index and Serum Parameters With Ultrasonographic Grade of Fatty Change in Non-alcoholic Fatty Liver Disease

Gender differences in the association of non-alcoholic fatty liver disease and metabolic syndrome with erosive oesophagitis: a cross-sectional study in a Taiwanese population

Nonalcoholic Steatohepatitis as Fatal Fatty Liver - The next main target in the field of liver disease

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