Viscoelastic microfluidics for enhanced separation resolution of submicron particles and extracellular vesicles

Hettiarachchi, Samith; Ouyang, Lingxi; Cha, Haotian; Hansen, Helena H. W. B.; An, Honjie; Nguyen, Nam-Trung; Zhang, Jun

doi:10.1039/d3nr05410a

Nanoscale

2024

DOI: 10.1039/d3nr05410a

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Viscoelastic microfluidics for enhanced separation resolution of submicron particles and extracellular vesicles

Samith Hettiarachchi,

Lingxi Ouyang,

Haotian Cha

et al.

Abstract: Manipulation, focusing, and separation of submicron- and nanoparticles such as extracellular vehicles (EVs), viruses and bacteria have broad applications in disease diagnostics and therapeutics. Viscoelastic microfluidic technology emerges as a...

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Cited by 4 publications

References 37 publications

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Periodic Flows in Microfluidics

Mudugamuwa,

Roshan,

Hettiarachchi

et al. 2024

Small

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Microfluidics, the science and technology of manipulating fluids in microscale channels, offers numerous advantages, such as low energy consumption, compact device size, precise control, fast reaction, and enhanced portability. These benefits have led to applications in biomedical assays, disease diagnostics, drug discovery, neuroscience, and so on. Fluid flow within microfluidic channels is typically in the laminar flow region, which is characterized by low Reynolds numbers but brings the challenge of efficient mixing of fluids. Periodic flows are time‐dependent fluid flows, featuring repetitive patterns that can significantly improve fluid mixing and extend the effective length of microchannels for submicron and nanoparticle manipulation. Besides, periodic flow is crucial in organ‐on‐a‐chip (OoC) for accurately modeling physiological processes, advancing disease understanding, drug development, and personalized medicine. Various techniques for generating periodic flows have been reported, including syringe pumps, peristalsis, and actuation based on electric, magnetic, acoustic, mechanical, pneumatic, and fluidic forces, yet comprehensive reviews on this topic remain limited. This paper aims to provide a comprehensive review of periodic flows in microfluidics, from fundamental mechanisms to generation techniques and applications. The challenges and future perspectives are also discussed to exploit the potential of periodic flows in microfluidics.

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Periodic Flows in Microfluidics

Mudugamuwa,

Roshan,

Hettiarachchi

et al. 2024

Small

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Applications of dielectrophoresis in microfluidic-based exosome separation and detection

Lan,

Yang

2024

Chemical Engineering Journal

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Ultra-Stretchable Microfluidic Devices for Optimizing Particle Manipulation in Viscoelastic Fluids

Kang,

Ma,

Cha

et al. 2024

ACS Appl. Mater. Interfaces

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Viscoelastic microfluidics leverages the unique properties of non-Newtonian fluids to manipulate and separate microor submicron particles. Channel geometry and dimension are crucial for device performance. Traditional rigid microfluidic devices require numerous iterations of fabrication and testing to optimize these parameters, which is time-consuming and costly. In this work, we developed a flexible microfluidic device using ultra-stretchable and biocompatible Flexdym material to overcome this issue. Our device allows for simultaneous modification of channel dimensions by external stretching. We fabricated a stretchable device with an initial square microchannel (30 μm × 30 μm), and the channel aspect ratio can be adjusted from 1 to 5 by external stretching. Next, the effects of aspect ratio, particle size, flow rate, and poly(ethylene oxide) (PEO) concentration that make the fluid viscoelastic on particle migration were investigated. Finally, we demonstrated the feasibility of our approach by testing channels with an aspect ratio of 3 for the separation of both particles and cells.

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Viscoelastic microfluidics for enhanced separation resolution of submicron particles and extracellular vesicles

Abstract: Manipulation, focusing, and separation of submicron- and nanoparticles such as extracellular vehicles (EVs), viruses and bacteria have broad applications in disease diagnostics and therapeutics. Viscoelastic microfluidic technology emerges as a...

Cited by 4 publications

References 37 publications

Periodic Flows in Microfluidics

Periodic Flows in Microfluidics

Applications of dielectrophoresis in microfluidic-based exosome separation and detection

Ultra-Stretchable Microfluidic Devices for Optimizing Particle Manipulation in Viscoelastic Fluids

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