Viscosity-controlled printing of supramolecular-polymeric hydrogels via dual-enzyme catalysis

Wei, Qingcong; Xu, Wei; Li, Mingyu; Wu, Qing; Cheng, Liming; Wang, Qigang

doi:10.1039/c6tb01792d

Cited by 23 publications

(26 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 103 − 105 Hydrogels based on reversible covalent bonds or supramolecular interactions are also promising to serve as printing materials for biomedical applications due to their self-healability at physiological conditions and multiresponsibility. 66 − 68 , 96 …”

Section: Applications Of Enzyme-regulated Healable Polymeric Hydrogelmentioning

confidence: 99%

“…We have especially discussed the enzymatic fabrication of healable hydrogels and enzymatically regulated healing of hydrogels. In the studies on enzymatic fabrication of healable polymeric hydrogels, enzymatic reactions mainly play the roles of triggering the self-assembly, 60 , 66 polymerization, 60 , 66 , 67 , 70 and formation of reversible covalent bonds 68 , 69 in hydrogels. The dual-enzymatic self-assembly and polymerization is a valid strategy developed by Wang and co-workers for the preparation of self-healing polymeric hydrogels, and the resulting hydrogels have found applications in 3D cell printing and hemostasis.…”

Section: Conclusion and Outlookmentioning

confidence: 99%

“…The dual-enzymatic self-assembly and polymerization is a valid strategy developed by Wang and co-workers for the preparation of self-healing polymeric hydrogels, and the resulting hydrogels have found applications in 3D cell printing and hemostasis. 60 , 66 , 67 The dynamic imide bond is one of the most frequently used reversible covalent bonds for the enzymatic formation of healable hydrogels, wherein amine oxidases are employed to partially oxidize the amino-containing macromolecules to the corresponding aldehyde products, therefore allowing the occurrence of the Schiff base reactions. 68 , 69 Single-network and dual-network healable polymeric hydrogels have been fabricated in this way for the applications of 3D printing and skin wound healing.…”

Section: Conclusion and Outlookmentioning

confidence: 99%

See 2 more Smart Citations

Enzyme-Regulated Healable Polymeric Hydrogels

Zhong

et al. 2020

ACS Cent. Sci.

View full text Add to dashboard Cite

The enzyme-regulated healable polymeric hydrogels are a kind of emerging soft material capable of repairing the structural defects and recovering the hydrogel properties, wherein their fabrication, self-healing, or degradation is mediated by enzymatic reactions. Despite achievements that have been made in controllable cross-linking and de-cross-linking of hydrogels by utilizing enzyme-catalyzed reactions in the past few years, this substrate-specific strategy for regulating healable polymeric hydrogels remains in its infancy, because both the intelligence and practicality of current man-made enzyme-regulated healable materials are far below the levels of living organisms. A systematic summary of current achievements and a reasonable prospect at this point can play positive roles for the future development in this field. This Outlook focuses on the emerging and rapidly developing research area of bioinspired enzyme-regulated self-healing polymeric hydrogel systems. The enzymatic fabrication and degradation of healable polymeric hydrogels, as well as the enzymatically regulated self-healing of polymeric hydrogels, are reviewed. The functions and applications of the enzyme-regulated healable polymeric hydrogels are discussed.

show abstract

Section: Applications Of Enzyme-regulated Healable Polymeric Hydrogelmentioning

confidence: 99%

Section: Conclusion and Outlookmentioning

confidence: 99%

Section: Conclusion and Outlookmentioning

confidence: 99%

See 1 more Smart Citation

Enzyme-Regulated Healable Polymeric Hydrogels

Zhong

et al. 2020

ACS Cent. Sci.

View full text Add to dashboard Cite

show abstract

“…22). [269] In these cases, enzymes are not directly involved in the cross-linking process, they are used as initiators for chain-growth polymerization. In that sense, enzyme-triggered free-radical polymerization cannot be properly considered as an enzyme-mediated cross-linking method.…”

Section: Enzyme-triggered Free-radical Polymerizationmentioning

confidence: 99%

Chemical cross-linking methods for cell encapsulation in hydrogels

Echalier

Valot

Martínez

et al. 2019

Materials Today Communications

View full text Add to dashboard Cite

Cell-encapsulating hydrogels are of tremendous interest in regenerative medicine. Tissue engineering relies on biomaterials able to act as artificial extracellular matrices to guide cells towards the development of new tissues. Therefore, considerable efforts have been made to design biomaterials which mimic cells' native environment, thus encouraging natural behavior. The choice of biomaterial in which cells are embedded is crucial for their survival, proliferation and differentiation. Being more stable, chemical hydrogels are preferred over physical hydrogels as cell-laden substrates. When designing chemical hydrogels, scientists must choose not only the nature of the network (synthetic and/or biopolymers) but also the type of cross-link bridging hydrogel constituents. For that purpose, numerous chemistries have been used (i) to introduce reactive functions on the hydrogel precursors and (ii) to form covalent bonds in the presence of living cells. The review will discuss the advantages and limitations of each strategy.

show abstract

“… 12 Other groups have employed an enzyme-trigger to switch-on an LMWG network. 13 Yang and co-workers demonstrated the ability of hybrid hydrogels to remain physically robust while extracting and releasing dyes from aqueous solutions, 14 then showed that a polymer additive could boost the anticancer activity of supramolecular LMWG nanofibres based on a taxol derivative. 15 Qi and co-workers developed hybrid hydrogels which incorporated taxol and achieved sustained release.…”

Section: Introductionmentioning

confidence: 99%