Although variation of chromaticity in medical liquid-crystal displays (LCDs) has created interest in the quality assurance and quality control of display devices for medical use, it is unknown how chromaticity varies with the viewing angle. Our aims in this study were to investigate the variations of chromaticity in grayscale images displayed on medical LCDs depending on viewing angles, and to examine color discrimination at different viewing angles. Variations in chromaticity, Δu'v', between 0° and each viewing angle (-60° to +60°) were investigated. The chromaticity of each LCD varied as the viewing angle changed. We examined confidence levels of color discrimination at different viewing angles by rotating the LCD for ten observers. When the viewing angle and variation in chromaticity increased, the confidence levels of color discrimination increased. Our results indicated that observers, such as radiologists and radiological technologists, could recognize variation in chromaticity at different viewing angles.