Visual deprivation selectively reshapes the intrinsic functional architecture of the anterior insula subregions

Liu, Lihua; Yuan, Congcong; Ding, Hao; Xu, Yongjie; Long, Miaomiao; Li, Yanjun; Liu, Yong; Jiang, Tianzi; Qin, Wen; Shen, Wen; Yu, Chunshui

doi:10.1038/srep45675

Cited by 14 publications

(16 citation statements)

References 83 publications

(150 reference statements)

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“…The right AI has been confirmed to be a functional hub in coordinating brain networks to produce adaptive behavior, especially the modulation in the DMN and DAN (Wang et al, 2018), as suggested in our study. A weakened functional connection in the early deprivation subject was discovered between the subregions of AI (Nomi et al, 2016; Liu et al, 2017), as the reduced connection from left AI to right AI in our study. Abnormalities within the IPL have been associated with working memory dysfunction as well as impairments in cognitive insight and reality perception (Guo et al, 2014; Lee et al, 2015; Chahine et al, 2017).…”

Section: Discussionsupporting

confidence: 53%

“…Our findings suggest that the specific abnormalities of the AI and general alterations within the IPL may be mediated by inhibitory interactions from other regions of the left dorsal attention network. A recent study in EB subjects also suggested that early visual deprivation can selectively reshape the functional architecture of the salience network (Liu et al, 2017). Our study found that most of the effective connections were decreased in the EB subjects, suggesting a corresponding reorganization of the human brain due to the early deprivation.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have suggested that the EB subjects showed a disruption of functional connectivity both in the visual cortex and other brain regions located in other cognitive brain networks (Liu et al, 2017; Dormal et al, 2018; Abboud and Cohen, 2019). Early deprivation could trigger the functional preference for the selective auditory recruitment in the cognitive brain networks (Dormal et al, 2018) and a reduction of the interhemispheric functional connectivity in the cognitive regions (Hou et al, 2017).…”

Section: Introductionmentioning

confidence: 97%

“…In addition to the DMN, two other distinct brain networks (ventral and dorsal) play a vital role in EB subjects in the allocation of attention (Jimenez et al, 2016). The ventral network consists of the temporoparietal junction, anterior cingulate cortex (ACC), and anterior insulae (AI), which has been suggested to be responsible for stimulus-driven attention (Jimenez et al, 2016; Liu et al, 2017; Wang et al, 2018). The other dorsal network, constituted of the lateral frontal eye field (FEF) as well as the bilateral superior parietal lobes (SPL), is correlated with the voluntary, sustained orienting of attention (Corbetta and Shulman, 2011; Tsvetanov et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients

Wang

et al. 2019

Front. Neurosci.

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Neuroimaging studies in early blind (EB) patients have shown altered connections or brain networks. However, it remains unclear how the causal relationships are disrupted within intrinsic brain networks. In our study, we used spectral dynamic causal modeling (DCM) to estimate the causal interactions using resting-state data in a group of 20 EB patients and 20 healthy controls (HC). Coupling parameters in specific regions were estimated, including the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), and inferior parietal lobule (IPC) in the default mode network (DMN); dorsal anterior cingulate cortex (dACC) and bilateral anterior insulae (AI) in the salience network (SN), and bilateral frontal eye fields (FEF) and superior parietal lobes (SPL) within the dorsal attention network (DAN). Statistical analyses found that all endogenous connections and the connections from the mPFC to bilateral IPCs in EB patients were significantly reduced within the DMN, and the effective connectivity from the PCC and lIPC to the mPFC, and from the mPFC to the PCC were enhanced. For the SN, all significant connections in EB patients were significantly decreased, except the intrinsic right AI connections. Within the DAN, more significant effective connections were observed to be reduced between the EB and HC groups, while only the connections from the right SPL to the left SPL and the intrinsic connection in the left SPL were significantly enhanced. Furthermore, discovery of more decreased effective connections in the EB subjects suggested that the disrupted causal interactions between specific regions are responsive to the compensatory brain plasticity in early deprivation.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients

Wang

et al. 2019

Front. Neurosci.

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“…Liu et al, 2007;Wang et al, 2013;Yu et al, 2008). By contrast, resting-state synchrony between "visual" cortices and frontal-parietal cortices is increased in blindness (Bedny et al, 2011;Bedny, Konkle, Pelphrey, Saxe, & Pascual-Leone, 2010;Burton et al, 2014;Deen, Saxe, & Bedny, 2015;L. Liu et al, 2017;Y.…”

Section: Insights Into the Relationship Of Connectivity And Function mentioning

confidence: 99%

“Visual” Cortices of Congenitally Blind Adults Respond to Executive Demands Authors

Loiotile

Bedny

2018

Preprint

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How functionally flexible is human cortex? In congenitally blind individuals, "visual" cortices are active during auditory and tactile tasks. The cognitive role of these responses and the underlying mechanisms remain uncertain. A dominant view is that, in blindness, "visual" cortices process information from low-level auditory and somatosensory systems. An alternative hypothesis is that higher-cognitive fronto-parietal systems take over "visual" cortices. We report that, in congenitally blind individuals, right-lateralized "visual" cortex responds to executiveload in a go/no-go task. These right-lateralized occipital cortices of blind, but not sighted, individuals mirrored the executive-function pattern observed in fronto-parietal systems. In blindness, the same "visual" cortex area, at rest, also increases its synchronization with prefrontal executive control regions and decreases its synchronization with auditory and sensorimotor cortices. These results support the hypothesis of top-down fronto-parietal takeover of "visual" cortices, and suggest that human cortex is highly flexible at birth.

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Abnormal cerebral blood flow in patients with Leber’s hereditary optic neuropathy

Wang

Ding

et al. 2023

Brain Imaging and Behavior

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The study aimed to unravel abnormal cerebral blood ow (CBF) in patients with Leber's hereditary optic neuropathy (LHON) using arterial spin labeling (ASL) and to investigate the associations among disrupted CBF, disease duration, and neuro-ophthalmological impairment. MethodsASL perfusion imaging data was collected from 20 patients with acute LHON, 29 patients with chronic LHON, and 37 healthy controls. We used a one-way analysis of covariance to test the intergroup differences in CBF. Linear and nonlinear curve t models were applied to explore the associations among CBF, disease duration, and neuroophthalmological metrics. ResultsBrain regions differed in LHON patients included the left sensorimotor and bilateral visual areas (p < 0.05, cluster-wise family-wise error correction). Acute and chronic LHON patients demonstrated lower CBF in bilateral calcarine than the healthy controls. Chronic LHON had lower CBF in the left middle frontal gyrus and sensorimotor cortex, and temporalpartial junction than the healthy controls and acute LHON. A signi cant logarithmic negative correlation was shown between CBF of left middle frontal gyrus and disease duration. There showed a signi cant logarithmic positive correlation between retinal nerve ber layer thickness and CBF in left middle frontal gyrus, and negative correlations between loss of variance and CBF in left middle frontal gyrus and sensorimotor cortex (p < 0.05, Bonferroni correction). ConclusionLHON patients exhibited reduced CBF in the visual pathway, sensorimotor and higher-tier cognitive areas. Disease duration and neuro-ophthalmological impairments can in uence the metabolism of non-visual areas.

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Visual deprivation selectively reshapes the intrinsic functional architecture of the anterior insula subregions

Cited by 14 publications

References 83 publications

Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients

Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients

“Visual” Cortices of Congenitally Blind Adults Respond to Executive Demands Authors

Abnormal cerebral blood flow in patients with Leber’s hereditary optic neuropathy

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