Visual evoked potential in the early diagnosis of glaucoma.  Literature review

Firan, Anne Marie; Istrate, Sînziana; Iancu, Raluca; Tudosescu, Ruxandra; Ciuluvică, Radu; Voinea, Liliana

doi:10.22336/rjo.2020.4

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…In our study, we noted no significant change in OCT results after 6 months of treatment. As report in literature the damage to the optic nerve observed by the reduction of the ganglion cell layer and the thickness of retinal fiber revealed by OCT correlates with the VEP latency parameters ( 28 ). However, these anomalies are later and appear after the impairment of the visual field.…”

Section: Discussionmentioning

confidence: 65%

“…Visual evoked potential is an important visual electrophysiological diagnostic exam, which can be used as an objective measure of optic nerve function. Correlations between the magnitude of VEP latency parameters and automated visual parameters have suggested that cortex responses in glaucoma patients could be tested by electrophysiological methods ( 28 ). Electrophysiology in glaucoma brings valued information, which detects macular ganglion cell dysfunction and VEP can be of aid in the evaluation of “glaucoma suspects” even before a detectable loss appears by visual field examination ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

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Prospective Assessment of Early Proton Therapy-Induced Optic Neuropathy in Patients With Intracranial, Orbital or Sinonasal Tumors: Impact of A Standardized Ophthalmological Follow Up

Lecornu

Lesueur²,

Salleron³

et al. 2021

Front. Oncol.

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PurposeProton therapy (PT) can be a good option to achieve tumor control while reducing the probability of radiation induced toxicities compared to X-ray-based radiotherapy. However, there are still uncertainties about the effects of PT on the organs in direct contact with the irradiated volume. The aim of this prospective series was to report 6-month follow-up of clinical and functional optic neuropathy rates of patients treated by proton therapy using a standardized comprehensive optic examination.Methods and MaterialsStandardized ophthalmological examinations were performed to analyze subclinical anomalies in a systematic way before treatment and 6 months after the end of proton therapy with: Automatic visual field, Visual evoked potential (VEP) and optic coherence of tomography (OCT).ResultsFrom October 2018 to July 2020 we analyzed 81 eyes. No significant differences were found in the analysis of the clinical examination of visual functions by the radiation oncologist. However, considering VEP, the impairment was statistically significant for both fibers explored at 30’angle (p:0.007) and 60’angle (p <0.001). In patients with toxicity, the distance of the target volume from the optical pathways was more important with a p-value for 30’VEP at 0.035 and for 60’VEP at 0.039.ConclusionsThese results confirm uncertainties concerning relative biological effectiveness of proton therapy, linear energy transfer appears to be more inhomogeneous especially in areas close to the target volumes. The follow-up of patients after proton therapy is not an easy process to set up but it is necessary to improve our knowledges about the biological effects of proton therapy in real life. Our study which will continue during the coming years, suggests that follow-up with in-depth examinations such as VEP as a biomarker could improve the detection of early abnormalities.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Prospective Assessment of Early Proton Therapy-Induced Optic Neuropathy in Patients With Intracranial, Orbital or Sinonasal Tumors: Impact of A Standardized Ophthalmological Follow Up

Lecornu

Lesueur²,

Salleron³

et al. 2021

Front. Oncol.

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“…The degree of the retinal, optic nerve and visual impairment may be rapidly and objectively determined by visual electrophysiological testing. The cerebral cortex generates bioelectricity when the retina is activated and this is known as the VEP ( 27 ). The VEP has a decreased amplitude and a delayed peak when the optic nerve is damaged by ocular trauma ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Altered brain network centrality in patients with orbital fracture: A resting‑state functional MRI study

Liu,

Gao,

Shu

et al. 2023

Exp Ther Med

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The present study aimed to investigate potential functional network brain-activity abnormalities in individuals with orbital fracture (OF) using the voxel-wise degree centrality (DC) technique. The present study included 20 patients with OF (12 males and 8 females) and 20 healthy controls (HC; 12 males and 8 females), who were matched for gender, age and educational attainment. Functional magnetic resonance imaging (fMRI) in the resting state has been widely applied in several fields. Receiver operating characteristic (ROC) curves were calculated to distinguish between patients with OF and HCs. In addition, correlation analyses were performed between behavioral performance and average DC values in various locations. The DC technique was used to assess unprompted brain activity. Right cerebellum 9 region (Cerebelum_9_R) and left cerebellar peduncle 2 area (Cerebelum_Crus2_L) DC values of patients with OF were increased compared with those in HCs. Cerebelum_9_R and Cerebelum_Crus2_L had area under the ROC curve values of 0.983 and 1.000, respectively. Patients with OF appear to have several brain regions that exhibited aberrant brain network characteristics, which raises the possibility of neuropathic causes and offers novel therapeutic options.

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“…Unlike the visual field assessments, they may of advantage as being completely objective, hence more unbiased examination of the function of the visual pathway. This objectiveness is because cognitive factors (like tiredness, stress and others) or patient"s motor skills (especially for the elder patients) are absent (35) .…”

Section: Visual Field Testingmentioning

confidence: 99%

Role of Visual Field Testing and OCT in Evaluation of Brimonidine as a Neuroprotector in Primary Open Angle Glaucoma

Nassar¹,

Khairy²,

Gohary³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Glaucoma is the leading cause of global irreversible blindness optic neuropathy and retinal ganglion cell (RGC) death are the hallmarks of glaucoma. If intraocular pressure (IOP) is held within "normal" ranges, the disease process and RGC death can still progress in some patients. Neuroprotective therapies for glaucoma should aim to halt RGC loss thus preventing further structural and functional damage of the optic nerve Objective: The aim of the current work was to study the ability of visual field testing and optical coherence tomography to reveal the neuroprotective role of brimonidine. Patients and Methods: This prospective randomized controlled trial study included a total of 98 eyes from 50 patients affected by primary open-angle glaucoma (POAG). They were recruited from a larger population of 70 POAG patients, attending at Menofiya University Hospitals. Results: The use of visual field-testing parameters have revealed that brimonidine had insignificantly halted glaucoma progression: MD (-0.1115 dB and -.2465 dB), VFI (-0.5882 and-1.1471) and PSD (0.1729 and 0.1894). On the other hand, some OCT parameters: average RNFL thickness (-0.7273 u and-2.2121 u), inferior RNFL thickness (-0.735 u and -1.559 u), superior RNFL thickness (-0.6364u and -1.4848 u), rim area (-0.0162 mm 2 and-0.0797 mm 2 ), average cup disc ratio (-0.01765 and 0.01824) and vertical cup disc ratio (-0.0167 and 0.0321) for study and control groups respectively, gave promising neuroprotective results for brimonidine. Conclusion:It could be concluded that the use of visual field-testing parameters (MD, VFI and PSD) has revealed that brimonidine had insignificantly halted glaucoma progression.

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Visual evoked potential in the early diagnosis of glaucoma. Literature review

Cited by 9 publications

References 15 publications

Prospective Assessment of Early Proton Therapy-Induced Optic Neuropathy in Patients With Intracranial, Orbital or Sinonasal Tumors: Impact of A Standardized Ophthalmological Follow Up

Prospective Assessment of Early Proton Therapy-Induced Optic Neuropathy in Patients With Intracranial, Orbital or Sinonasal Tumors: Impact of A Standardized Ophthalmological Follow Up

Altered brain network centrality in patients with orbital fracture: A resting‑state functional MRI study

Role of Visual Field Testing and OCT in Evaluation of Brimonidine as a Neuroprotector in Primary Open Angle Glaucoma

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