Visual Field Progression in Patients with Primary Angle-Closure Glaucoma Using Pointwise Linear Regression Analysis

Verma, Sushma; Nongpiur, Monisha E.; Atalay, Eray; Wei, Xin; Husain, Rahat; Goh, David; Perera, Shamira; Aung, Tin

doi:10.1016/j.ophtha.2017.02.027

Cited by 22 publications

(21 citation statements)

References 39 publications

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“…Moreover, the highest IOP detected in each year throughout the study was the only progression factor in PACG patients [2]. Following up PACG patients for over 10 years, Verma et al noted the progression in 15.8% patients, with the average ROP of − 0.12 dB/year [3]. ese data differ from those obtained in our study.…”

Section: Discussioncontrasting

confidence: 97%

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Selective Laser Trabeculoplasty Protects Glaucoma Progression in the Initial Primary Open-Angle Glaucoma and Angle-Closure Glaucoma after Laser Peripheral Iridotomy in the Long Term

Kurysheva¹,

Lepeshkina

2019

BioMed Research International

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Purpose. To compare the ability of SLT in preventing glaucoma progression in the initial primary angle-closure glaucoma (PACG) after laser peripheral iridotomy and primary open-angle glaucoma (POAG) in the long term. Methods. 60 patients with the initial stage of PACG after laser peripheral iridotomy and 64 initial POAG patients were recruited in a prospective study. Complete success of selective laser trabeculoplasty (SLT) was defined as a 20% intraocular pressure (IOP) reduction with topical hypotensive medications without any hypotensive intervention. Pre-SLT rate of progression and post-SLT rate of progression (ROP) was detected in the both groups by means of the trend and the event analysis of perimetry, the Guided Progression Analysis, and the optical coherence tomography- (OCT-) based negative trend for either the thickness of the peripapillary retinal nerve fiber layer (RNFL) or ganglion cell complex (GCC). Results. IOP decreased significantly after SLT in both the groups. 30% in PACG and 19% in POAG had the progression according to perimetry and 49% in PACG and 40% in POAG had the progression, respectively, according to OCT. After SLT, ROP was reduced from −0.14 ± 0.39 dB/year to −0.08 ± 0.48 dB/year, p=0.034, in PACG and from −0.09 ± 0.36 dB/year to −0.04 ± 0.43 dB/year, p=0.021, in POAG. According to RNFL trend analysis, ROP was reduced from −1.86 ± 2.9 μm/year to −1.38 ± 2.2 μm/year, p=0.039, and from −1.24 ± 2.23 μm/year to −0.76 ± 1.73 μm/year, p=0.037, in PACG and POAG, and according to GCC, ROP was reduced from −1.88 ± 2.9 μm/year to −1.34 ± 2.0 μm/year, p=0.040, and from −1.35 ± 2.16 μm/year to −0.91 ± 1.86 μm/year, p=0.040, in PACG and POAG, respectively. ROP was significantly faster in PACD than in POAG between 2 and 6 years after SLT: −0.15 ± 0.46 dB/year and 0.02 ± 0.38 dB/year (p=0.042). However, it did not differ significantly according to OCT. Conclusion. SLT is an effective treatment for initial PACG after LPI and POAG that can prevent functional and structural deterioration in the long term.

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Section: Discussioncontrasting

confidence: 97%

“…16 million people suffer from PACG worldwide [1]. Moreover, it progresses faster than primary open-angle glaucoma (POAG) [2] with a rapid progression in more than 57% of patients [3]. A quarter of all patients has one blind eye, and 4 million patients with PACG are totally blind [4].…”

Section: Introductionmentioning

confidence: 99%

Selective Laser Trabeculoplasty Protects Glaucoma Progression in the Initial Primary Open-Angle Glaucoma and Angle-Closure Glaucoma after Laser Peripheral Iridotomy in the Long Term

Kurysheva¹,

Lepeshkina

2019

BioMed Research International

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“…Similar slow progression rates were reported in the study by De Moraes and colleagues 56 : the mean rate of VF loss of À0.48 and À0.39 dB/y in POAG and PACG eyes, respectively. Verma and colleagues 36 reported even slower progression rate in PACG eyes (À0.12 dB/y). 56 There are other previous studies that reported faster rates of progression in PACG eyes compared to POAG eyes, and hence PACG has a threefold greater risk of developing blindness compared to POAG.…”

Section: Discussionmentioning

confidence: 94%

“…However, a recent study has investigated the rates of VF loss in eyes with PACG. 36 It has been reported in some of the population-based studies that the rate of glaucoma-induced blindness is greater in eyes with PACG compared to eyes with POAG. This might suggest that the progression course in eyes with PACG is more aggressive than eyes with POAG.…”

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confidence: 99%

Rates of Visual Field Loss in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma: Asymmetric Patterns

Yousefi

Murata

Fujino

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to evaluate the rate of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). METHODS. Four hundred forty eyes of 282 patients with POAG (aged 53.4 6 12.0: mean 6 standard deviation, years) and 79 eyes of 49 patients with PACG (aged 62.7 6 9.0 years) with at least six or more reliable VF tests were studied. Point-wise, region-wise, and global rates of VF change were assessed for POAG and PACG eyes. Only the VF records prior to laser iridotomy or cataract surgery were included in PACG eyes. The global and superior-inferior asymmetric rates of VF loss were compared between POAG and PACG eyes. RESULTS. The mean total deviation (mTD) values at baseline were À6.4 6 5.7 dB in POAG patients and À6.4 6 7.3 dB in PACG patients. There was not a significant difference in the progression rates of mTD between POAG eyes (À0.23 6 0.38 dB/y) and PACG eyes (À0.29 6 0.45 dB/y). In POAG eyes, the VF progression rate was significantly asymmetric across the horizontal line; the central, paracentral, and peripheral arcuate 2 regions in the superior hemifield had a significantly faster rate of VF loss than their inferior counterparts. In contrast, this asymmetry was not observed in the rate of VF loss in PACG eyes. CONCLUSIONS. POAG eyes showed a faster rate of VF loss in the superior hemifield compared to in the inferior hemifield, particularly in central and paracentral regions. This difference was not observed in PACG eyes.

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“…Cross-sectional studies comparing the total deviation values of the superior hemifield with that of the inferior hemifield at various stages (mild, moderate, and severe) of PACG reported greater total deviation values in the superior than in the inferior hemifield. 25,50 Verma et al 51 have shown that in early PACG, greater number of locations progressed in superior temporal Garway-Heath (GH) VF sector compared to inferior temporal GH VF sector. The reason for this discrepancy between Verma et al 51 and our study results may be due to the difference in the criteria for progression used in these studies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Visual Field Progression Rates Among the High Tension Glaucoma, Primary Angle Closure Glaucoma, and Normal Tension Glaucoma

Ganeshrao

Senthil

Choudhari

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To compare the visual field (VF) progression among high tension glaucoma (HTG), primary angle closure glaucoma (PACG), and normal tension glaucoma (NTG) subjects in routine clinical care. METHODS. All patients had ‡5 VF tests using HFA, 24-2, SITA-standard strategy. We compared the progression between glaucoma subtypes after matching the VFs for baseline severity (mean deviation [MD]) and the age at presentation. Global VF progression was evaluated by linear regression analysis (LRA) of MD. For local VF progression, scotoma expansion (SE) defined as appearance of new scotoma and scotoma deepening (SD) defined by pointwise LRA were calculated. SE and SD were analyzed in three VF zones: superior arcuate (SA), inferior arcuate (IA), and central (C). RESULTS. A total of 310 HTG, 304 PACG, and 165 NTG eyes were included. When VFs were matched by baseline MD, a greater number (n ¼ 20/76) of eyes with HTG showed significant progression compared to PACG (n ¼ 9/76; P ¼ 0.04). The number of progressing eyes were not significantly different between HTG and NTG (n ¼ 11/76; P ¼ 0.10) and between NTG and PACG (P ¼ 0.65). When the baseline VFs were matched by age, the number of eyes showing significant progression were similar in all the subtypes. SA zone in HTG and NTG showed greater SE and SD compared to other zones (P < 0.05), whereas IA zone in PACG showed greater SE and SD compared to other zones (P < 0.05). CONCLUSIONS. In our cohort of treated primary glaucoma with matched baseline severity, a greater proportion of HTG eyes progressed faster compared to PACG. SA zone in HTG and NTG and IA zone in PACG showed greater VF progression.

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Visual Field Progression in Patients with Primary Angle-Closure Glaucoma Using Pointwise Linear Regression Analysis

Cited by 22 publications

References 39 publications

Selective Laser Trabeculoplasty Protects Glaucoma Progression in the Initial Primary Open-Angle Glaucoma and Angle-Closure Glaucoma after Laser Peripheral Iridotomy in the Long Term

Selective Laser Trabeculoplasty Protects Glaucoma Progression in the Initial Primary Open-Angle Glaucoma and Angle-Closure Glaucoma after Laser Peripheral Iridotomy in the Long Term

Rates of Visual Field Loss in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma: Asymmetric Patterns

Comparison of Visual Field Progression Rates Among the High Tension Glaucoma, Primary Angle Closure Glaucoma, and Normal Tension Glaucoma

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