Visual Hallucinations with Methylphenidate and Acetaminophen in Combination

Hallucinations and other psychotic symptoms in response to methylphenidate in children and adolescents with attention-deficit/hyperactivity disorder: a Cochrane systematic review with meta-analysis and trial sequential analysis#

“…Time from ingestion of methylphenidate to initiation of psychotic symptoms varied from 1 hour to 1 day. The duration of psychotic symptoms varied from 2 hours to 1 day, except for one patient, who had psychotic symptoms for 1 week coinciding with the co-administration of acetaminophen (88). The psychotic symptoms remitted upon methylphenidate withdrawal in 16 of 16 patients.…”

“…In two of four patients, a re-challenge with methylphenidate was followed by the recurrence of symptoms (80,81). Furthermore, eight patients were reported to be followed up between 3 months and 3 years after the occurrence of psychotic symptoms (77,79,80,82,83,88), and only one patient continued to have symptoms (77). At follow-up, he was still receiving methylphenidate and was diagnosed with schizophrenia.…”

“…We included 10 randomized clinical trials [four parallel group trials (46-50) and six cross-over trials (51)(52)(53)(54)(55)(56)(57)] totalling 1103 participants, 17 nonrandomized studies (49,58-75) totalling 76,237 participants and 12 patient reports or small series describing 18 patients (76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88).…”

Psychiatric Adverse Effects of Non-steroidal Analgesic Anti-inflammatory Drugs

“…Bu bildirimde, asetaminofen ve metilfenidat kombinasyonunun beyinde aşırı derecede dopamin artışına neden olduğu söylenebilmektedir. 18 Bir kohort çalışmasında, prenatal dönemde asetaminofen maruziyeti sonucu çocuklarda DEHB benzeri davranış bozuklukları veya hiperkinetik bozukluklar gelişme riski değerlendirilmiştir. 1996-2002 yılları arasında, 64.232 canlı doğan çocuklar ve Danimarka Ulusal Doğum Kohortu'na kayıtlı anneler ile çalışılmıştır.…”