Visual improvement in a patient with paracentral acute middle maculopathy treated with prostaglandin E1

Abstract

paracentral acute middle maculopathy, acute retinal ischemia, prostaglandin E1 The authors present the use of prostaglandin E1 (PGE1) for the treatment of an acute paracentral acute middle maculopathy (PAMM). A 78-year-old white female was seen with a sudden loss of vision in her left eye (OS) to 20/200 noted upon awakening. The right eye (OD) saw 20/20. A complete eye exam was done and an ocular coherent tomography revealed retinal thickening and a whitening of the inner nuclear layer in the area of the macula OS. A diagnosis of PAMM in the OS was made. Treatment was immediately started with 70 μg of PGE1 administered over 1.5 hours in the form of a skin cream. A volume of 3.5 cc of skin cream was applied in divided doses to the inner surface of the forearm, rubbed into the skin and allowed to dry. The same 70 μg of PGE1 in 3.5 cc of skin cream was repeated once the next morning. The patient began to see better the second day of treatment with a final visual acuity of 20/20. The OD was unchanged. After 14 months she was stable with no further treatment. PAMM is an ischemic process of the inner retina. PGE1, a potent vasodilator of the microcirculation, when given immediately seemed to be useful in restoring vision in this form of retinal ischemia. Treatment was immediately started with PGE1 in the form of a skin cream with visual improvement. The authors normally use PGE1 intravenously for acute ocular ischemia and would have preferred that here. Intravenous PGE1 was not available and was substituted with the skin cream of PGE1 that worked well for the patient.

Clinical evaluation of Alprostadil combined with Nimodipine in treatment of Cerebral Vasospasm after Subarachnoid Hemorrhage in elderly patients

“…Its injection is carried by lipid microsphere, which not only ensures drug activity, but also helps it target the site of vascular damage. 20,21 Plasma viscosity, whole blood viscosity at high shear, whole blood viscosity at low shear, hematocrit and platelet adhesion are important indicators of blood fluidity. The higher the values, the higher the blood viscosity and the resistance during blood flow, which will affect the blood supply of organs, thus leading to diseases.…”

Paracentral Acute Middle Maculopathy in Giant Cell Arteritis

“…27 Hence, the addition of a vasodilating agent could be useful, as shown in Case 1. A Japanese team published a case of PAMM with improvement of visual acuity after the application of a prostaglandin E1–based cream, 28( p 1) but further studies with a larger number of patients are needed to validate this therapy.…”