Visual interpretation of brain hypometabolism related to neurological long COVID: a French multicentric experience

Verger, Antoine; Kas, Aurélie; Dudouet, P.; Goehringer, François; Salmon‐Céron, Dominique; Guedj, Éric

doi:10.1007/s00259-022-05753-5

Cited by 40 publications

(31 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a large sample study, long COVID patients showed a widespread reduction of metabolism in the bilateral rectal or orbital gyri, right hippocampus and amygdala, brainstem, and cerebellum, which helped to distinguish between patients and healthy controls clearly with 100% accuracy 78 . This long COVID hypometabolic pattern was replicated using visual assessment in another multicenter study 79 . Similar hypometabolic patterns in the bilateral medial temporal lobes, brain stem, and cerebellum were also found in pediatric long COVID cases, which suggests similar mechanisms of long COVID syndrome regardless of age 80 .…”

Section: Examinations Of Long Covidmentioning

confidence: 80%

Neuropsychiatric aspects of long COVID: A comprehensive review

Kubota

Sone

2022

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Although some patients have persistent symptoms or develop new symptoms following coronavirus disease 2019 (COVID-19) infection, neuropsychiatric aspects of long COVID are not well known. This review summarizes and provides an update on the neuropsychiatric dimensions of long COVID. Its neuropsychiatric manifestations commonly include fatigue, cognitive impairment, sleep disorders, depression, anxiety, and post-traumatic stress disorder. There are no specific tests for long COVID, but some characteristic findings such as hypometabolism on positron emission tomography have been reported. The possible mechanisms of long COVID include inflammation, ischemic effects, direct viral invasion, and social and environmental changes. Some patient characteristics and the severity and complications of acute COVID-19 infection may be associated with an increased risk of neuropsychiatric symptoms.Long COVID may resolve spontaneously or persist, depending on the type of neuropsychiatric symptoms. Although established treatments are lacking, various psychological and pharmacological treatments have been attempted. Vaccination against COVID-19 infection plays a key role in the prevention of long coronavirus disease. With differences among the SARS-CoV-2 variants, including the omicron variant, the aspects of long COVID are likely to change in the future. Further studies clarifying the aspects of long COVID to develop effective treatments are warranted.

show abstract

Section: Examinations Of Long Covidmentioning

confidence: 80%

Neuropsychiatric aspects of long COVID: A comprehensive review

Kubota

Sone

2022

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…Among 18 F-FDG PET brain scans from 143 patients performed at 10.9 (±4.8) months from COVID-19 symptom onset, 53% were visually interpreted as normal, 21% as mildly to moderately or incompletely affected, and 26% as severely affected according to the COVID hypometabolic pattern. Major metabolic changes were found in the limbic/paralimbic regions, including fronto-orbital olfactory regions, pons and cerebellum ( Verger et al, 2022 ). Dressing et al (2022) examined a group of 31 outpatients with neurocognitive symptoms persisting for more than three months after confirmed COVID-19.…”

Section: Alterations In Anatomical and Functional Brain Parameters In...mentioning

confidence: 99%

Psychiatric and neurological complications of long COVID

Zawilska

Kuczyńska

2022

Journal of Psychiatric Research

View full text Add to dashboard Cite

“…Ferner wurden gewebsschädigungsbedingte, fokale und diffuse, direkte und indirekte Veränderungen des Metabolismus in verbundenen Hirngebieten als Ursachen kognitiver Leistungsminderungen beim Post-COVID-Syndrom in Studien nahegelegt. Neben virusinduzierten Veränderungen können auch Nebenwirkungen der COVID-19-Therapie zu Langzeitfolgen führen [9][10][11][12].…”

Section: Symptome Bestehen Bis Zu 4 Wochenunclassified

“…Auch ist es so, dass Hirnfunktionsstörungen wie kognitive Störungen als "Netzwerk"-Störungen des Gehirns zu betrachten sind; entsprechend kann bei Long-/Post-COVID auch ein regional geminderter Hirnstoffwechsel beobachtet werden. Besonders von Hypometabolismus betroffen bei neurologischem Post-COVID-Syndrom sind frontobasale paramediane Regionen, der Hirnstamm und das Kleinhirn [11].…”

Section: Introductionunclassified

S1-Leitlinie Long-/Post-COVID

et al. 2022

View full text Add to dashboard Cite

ZusammenfassungDie Deutsche Gesellschaft für Pneumologie hat 2021 die AWMF S1-Leitlinie Long-/Post-COVID initiiert. In einem breiten interdisziplinären Ansatz wurde diese S1-Leitlinie basierend auf dem aktuellen Wissensstand gestaltet.Die klinische Empfehlung beschreibt die aktuellen Long- bzw. Post-COVID-Symptome, diagnostische Ansätze und Therapien.Neben der allgemeinen und konsentierten Einführung wurde ein fachspezifischer Zugang gewählt, der den aktuellen Wissensstand zusammenfasst.Die Leitlinie hat einen explizit praktischen Anspruch und wird basierend auf dem aktuellen Wissenszugewinn vom Autorenteam weiterentwickelt und adaptiert.

show abstract

Visual interpretation of brain hypometabolism related to neurological long COVID: a French multicentric experience

Cited by 40 publications

References 12 publications

Neuropsychiatric aspects of long COVID: A comprehensive review

Neuropsychiatric aspects of long COVID: A comprehensive review

Psychiatric and neurological complications of long COVID

S1-Leitlinie Long-/Post-COVID

Contact Info

Product

Resources

About