Visual Observations of SERRS from Single Silver‐Coated Silica Microparticles within Optical Tweezers

McNay, Graeme; Docherty, F. T.; Graham, Duncan; Smith, W. Ewen; Jordan, Pamela; Padgett, Miles J.; Leach, Jonathan; Sinclair, Gavin; Monaghan, Paul; Cooper, Jonathan M.

doi:10.1002/anie.200352999

Cited by 19 publications

(14 citation statements)

References 14 publications

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“…Using this method, very high resolution images can be obtained and very precise measurements of the distance dependence of the tip from the surface can be made. 70 Other applications include the use of SERS/SERRS in art, 71 for in situ detection in microfluidic devices, 72 in optical tweezers, 73 and its use for identification at a distance where a SERRS spectrum has been obtained from a preformed target of dye-labeled silver colloid particles dispersed in a varnish at 20 meters. 73 …”

Section: Examples Of Practical Applicationsmentioning

confidence: 99%

Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Resonance Raman Scattering (SERRS): A Review of Applications

et al. 2011

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Surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS) can provide positive identification of an analyte or an analyte mixture with high sensitivity and selectivity. Better understanding of the theory and advances in the understanding of the practice have led to the development of practical applications in which the unique advantages of SERS/SERRS have been used to provide effective solutions to difficult analytical problems. This review presents a basic theory and illustrates the way in which SERS/SERRS has been developed for practical use.

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Section: Examples Of Practical Applicationsmentioning

confidence: 99%

Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Resonance Raman Scattering (SERRS): A Review of Applications

et al. 2011

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“…This phenomenon is called surfaceenhanced Raman scattering (SERS) (Fleischm et al 1974;Kneipp et al 1996;Nie and Emery 1997;Michaels et al 1999). Recently, SERS spectroscopy with the optical trapping technique has attracted considerable attention (McNay et al 2004;Svedberg and Kall 2006;Itoh et al 2006;Yoshikawa et al 2007). …”

Section: Sers Detection Of Biomolecules With Optical Trapping Of Ag Nmentioning

confidence: 98%

Novel Nanobiosensing Using a Focused Laser Beam

Yoshikawa

2015

Nanobiosensors and Nanobioanalyses

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Lasers are very useful in nanobiosensing. The laser beam is spatially coherent and can be tightly focused by lenses. Interactions of photons with matter in the laser focus enable micro-and nanoscale analyses of a small objective in a specific area. In addition, focusing a laser beam induces photochemical reactions and optical forces in a sub-micron region of molecular solutions and nanoparticle dispersions. These effects of a focused laser beam are utilized for developing rapid, sensitive, compact, and low-cost biosensors, which are required for applications in point-of-care diagnostics, food safety controls, and environmental monitoring. In the first part of this chapter, a biosensing technique is introduced which works by simply focusing a single laser beam and detecting its reflection intensity. The polymer nanostructure deposited in a laser focus due to self-catalytic oxidative photopolymerization converts the enzyme reactions of horseradish peroxidase into a back-reflected intensity of the focused laser beam. A reliable optical quantification of glucose can be performed in a short time on a small sample volume. Another biosensing technique based on optical trapping of Ag nanoparticles is effective for sensitive biomolecular detection in solution. A focused laser beam immobilizes Ag nanoparticles with analyte molecules at a local spot on a polymer substrate. Surfaceenhanced Raman scattering of analyte molecules can be measured by irradiation of a visible-light excitation laser beam. Adenine molecules are detected quantitatively in a concentration range from 0.01 to 1 μM.

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“…One successful approach is trapping with a laser with a frequency significantly different from the localized surface plasmon resonance . In another approach, transparent particles can be metalized to create optically trappable SERS probes …”

Section: Applications For Biological Samplesmentioning

confidence: 99%

Strategies for Optical Trapping in Biological Samples: Aiming at Microrobotic Surgeons

Bunea

Glückstad

2019

Laser & Photonics Reviews

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Optical trapping and manipulation of objects down to the Ångstrom level has revolutionized research at the smallest scales in all natural sciences. The flexibility of optical trapping methods facilitates real‐time monitoring of the dynamics of biological processes in model systems and even in living cells. Different optical trapping and manipulation approaches allow displacement of nanostructures with subnanometer precision and force measurements with femtonewton precision. Due to inherent constraints of optical methods, most optical trapping experiments are performed in water or simple aqueous solutions. However, in recent years, there is an ever‐growing interest of shifting from simple aqueous media towards more biologically‐relevant media. Precise optical trapping and manipulation, combined with state‐of‐the‐art microfabrication, will enable the development of microrobotic “surgeons” with tremendous potential for biomedical and microengineering applications. This review introduces the basics of optical trapping and discusses its applications for biological samples, with focus on trapping in biological media and strategies for overcoming the challenges of optical manipulation in complex environments as a stepping‐stone for microrobotic “surgeons.”

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Visual Observations of SERRS from Single Silver‐Coated Silica Microparticles within Optical Tweezers

Cited by 19 publications

References 14 publications

Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Resonance Raman Scattering (SERRS): A Review of Applications

Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Resonance Raman Scattering (SERRS): A Review of Applications

Novel Nanobiosensing Using a Focused Laser Beam

Strategies for Optical Trapping in Biological Samples: Aiming at Microrobotic Surgeons

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