Visual outcome in herpes simplex virus and varicella zoster virus uveitis

This retrospective study was designed to estimate the cumulative incidence of glaucoma in viral uveitis. Seventy-six consecutive patients with viral stromal keratouveitis were divided into two groups according to the etiologic agents herpes simplex virus (HSV) keratouveitis (n = 58) and herpes zoster virus (HZV) keratouveitis (n = 18). The groups were evaluated for the incidence and prognosis of ocular hypertension. Etiologic agents were determined with the help of clinical observation supported by the polymerase chain reaction (PCR) of aqueous humor. All patients received oral acyclovir therapy for at least six months and topical prednisolone in tapered doses. There was no significant difference in the recurrences of HSV and varicella zoster virus (VZV) keratouveitis between groups (P = 0.431). The total incidence of secondary glaucoma was 13.1%. Most of the patients responded to antiviral and antiglaucomatous therapy. Trabeculectomy with mitomycin C was performed in only two patients. Secondary glaucoma can be regarded as a frequent complication of viral uveitis. As it has a good prognosis, surgical intervention is rarely required.

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“…[7]. Although recurrences may continue with long-term treatment, severity of the recurrences and the rates of complications are smaller [8].…”

Section: Discussionmentioning

confidence: 99%

Incidence and prognosis of ocular hypertension secondary to viral uveitis

et al. 2009

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“…In the Mayo clinic and other studies of HZO, 50-72% had ocular involvement. [9,11] Among the various ocular structures involved, corneal involvement was the most common and occurred in 10 patients(62.5%). In a study by Liesegang T., corneal complications were seen in 65% of all the cases of HZO.…”

Section: Discussionmentioning

confidence: 99%

A Clinical Study of Herpes Zoster Ophthalmicus

S.Maiya¹

2013

IOSR-JDMS

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“…37 Miserocchi et al reported the prevalence of SG in herpes simplex keratouveitis and zoster uveitis to be as high as 54 and 38% respectively. 38 Westfall et al reported the prevalence of elevated IOP (>21) in patients with active retinochoroiditis secondary to toxoplasmosis to be as high as 38%. This prevalence was much higher than in the control group (10%) of age-and gendermatched patients with active unilateral anterior uveitis and the difference was statistically significant.…”

Section: Specific Uveitic Syndromesmentioning

confidence: 99%

Uveitis and Glaucoma: A Critical Review

Mahajan¹,

Venkatesh²,

Garg³

2011

JOCGP

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Raised intraocular pressure is a frequently encountered complication of uveitis. Intraocular homeostasis, maintained by the impermeable blood-ocular barrier, is important to guarantee optimal visual function. During uveitis breakdown of the blood-ocular barrier occurs, allowing the influx of proteins as well as inflammatory and immunocompetent cells. The combination of action of inflammatory cells and the mediators they release; and the chronic corticosteroid therapy used to treat the uveitis can participate in the pathogenesis of uveitic glaucoma. These factors alter the normal anatomic structure of the anterior chamber and angle. Management of uveitic glaucoma may be difficult because of the numerous mechanisms involved in its pathogenesis and is guided by careful delineation of the pathophysiology involved in each individual case. This article reviews, in detail, the pathogenesis of uveitic glaucoma and its therapies, with emphasis on the recent developments in the subject.

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Visual outcome in herpes simplex virus and varicella zoster virus uveitis

Cited by 98 publications

References 30 publications

Incidence and prognosis of ocular hypertension secondary to viral uveitis

Incidence and prognosis of ocular hypertension secondary to viral uveitis

A Clinical Study of Herpes Zoster Ophthalmicus

Uveitis and Glaucoma: A Critical Review

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