Visual Sequelae of Closed Head Trauma

Gerner, Edward W.

doi:10.1007/978-1-4612-4366-3_13

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following the impact, the craniotomy is typically covered with a protective material, and the scalp incision is sutured. While this is a well-characterized method for preclinical TBI in pigs [ 37 , 61 , 62 , 63 , 64 , 65 ], most human brain injuries are closed-head injuries [ 66 ]. Craniotomy-based models primarily mimic open-head injuries such as impalement or gunshot wounds, which may not fully capture the complexities and mechanisms of closed-head injuries, as the CCI is typically conducted with the pig’s head secured in a stereotaxic frame, not allowing for any movement of the head during impact.…”

Section: Reviewmentioning

confidence: 99%

The Pig as a Translational Animal Model for Biobehavioral and Neurotrauma Research

Netzley

Pelled

2023

Biomedicines

View full text Add to dashboard Cite

In recent decades, the pig has attracted considerable attention as an important intermediary model animal in translational biobehavioral research due to major similarities between pig and human neuroanatomy, physiology, and behavior. As a result, there is growing interest in using pigs to model many human neurological conditions and injuries. Pigs are highly intelligent and are capable of performing a wide range of behaviors, which can provide valuable insight into the effects of various neurological disease states. One area in which the pig has emerged as a particularly relevant model species is in the realm of neurotrauma research. Indeed, the number of investigators developing injury models and assessing treatment options in pigs is ever-expanding. In this review, we examine the use of pigs for cognitive and behavioral research as well as some commonly used physiological assessment methods. We also discuss the current usage of pigs as a model for the study of traumatic brain injury. We conclude that the pig is a valuable animal species for studying cognition and the physiological effect of disease, and it has the potential to contribute to the development of new treatments and therapies for human neurological and psychiatric disorders.

show abstract