Visualising reactive oxygen species in live mammals and revealing of ROS-related system

Guo, Jingke; Xu, Hang; Liu, Shutao; Zi-cai, Wang; Dai, You; Lu, Jianzhi; Shan, Z.S.; Xu, Dan; Zhou, Jingran; Liu, Ke; Cheng, Xi; Xu, Mingming; Zhang, Xin; Guo, Yi; Lin, Yingjie; Ding, Wei; Gao, Guanzhen; Wang, Huiqin; Chen, Qi; Yu, Xiaowei; Han, Chunming; Qin, Lanfang; Sun, Xicui; Li, Zhe; Zheng, Shuyu; Wang, Jiaqi; Cheng, Yanglei; Qiu, Shuai; Hu, Yuqiu; Huang, Penghan; Lin, Chuntong; Wu, Qiming; Li, Yubo; Chen, Tianbao; Shaw, Chris; Ho, Sherry; Wang, Qiang; Gu, Huaiyu; Rao, Pingfan

doi:10.1080/10715762.2019.1677902

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…In our studies of reactive oxygen species (ROS) distribution in living animals by ROS indicator visualization, a few vertical fluorescent lines were demonstrated on the body. They could be almost perfectly superimposed on a standard human acupuncture meridian network [ 20 , 21 ]. ROS has a strong connection with REDOX potential (ORP) and antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

The Meridian Tropism and Classification of Red Yeast Rice Investigated by Monitoring Dermal Electrical Potential

Wang

Guo

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Red yeast rice is a traditional Chinese medicine and food that has been purported to color food, ferment, and lower cholesterol. In order to study the antioxidative capacity of red yeast rice and the effects on electrical potential difference (EPD) of 12 acupuncture meridians, the pH value, oxidation reduction potential (ORP), ABTS, FRAP, T-SOD, and particle size distribution of red yeast rice were analyzed. 20 volunteers were recruited and randomly divided into two groups, the red yeast rice group (10 g red yeast rice and 40 g water) and control CK group (50 g water). The left 12 acupuncture meridians’ EPD was real-time monitored. Samples were taken at the 10th minutes. The whole procedure continued for 70 minutes. It is shown that the pH value of the red yeast rice was 4.22, the ORP was 359.63 mV, the ABTS was 0.48 mmol Trolox, the FRAP was 0.08 mmol FeSO4, the T-SOD was 4.71 U, and the average particle size was 108 nm (7.1%) and 398.1 nm (92.9%). The results of 12 acupuncture meridians’ EPD showed that the red yeast rice can significantly affect the EPD of stomach, heart, small intestine, and liver meridians.

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Section: Discussionmentioning

confidence: 99%

The Meridian Tropism and Classification of Red Yeast Rice Investigated by Monitoring Dermal Electrical Potential

Wang

Guo

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…It is reported that hyperglycemia in diabetes induces overproduction of superoxide by the mitochondrial electron transport chain 12 . Recently, Guo et al revealed that mitochondria-producing superoxide could transmit to the extracellular matrix 13 . This overproduced superoxide is hypothesized to cause oxidative stress and damage in intestinal tissue 14 .…”

Section: Introductionmentioning

confidence: 99%

Glucose-lowering effects of orally administered superoxide dismutase in type 2 diabetic model rats

et al. 2022

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Superoxide dismutase (SOD) is an enzyme found in most food sources, might be a candidate to reduce oxidative damage to intestinal barrier, thereby ameliorating the vicious circle between hyperglycemia and the oxidative damage. Here we report the oral administration of SOD, liposome-embedded SOD (L-SOD), and SOD hydrolysate to type 2 diabetic model rats to confirm this hypothesis. Oxidative damage severity in model rat intestine was indicated by malondialdehyde level, GSSG/GSH ratio, and antioxidant enzyme activity. The damage was significantly repaired by L-SOD. Furthermore, blood glucose and related indexes correlated well not only with oxidative damage results but also with indexes indicating physical intestinal damage such as colon density, H&E staining, immunohistochemical analysis of the tight junction proteins occludin and ZO-1 in the colon, as well as lipopolysaccharide and related inflammatory cytokine levels. The order of the magnitude of the effects of these SOD preparations was L-SOD > SOD > SOD hydrolysate. These data indicate that orally administered SOD can exhibit glucose-lowering effect via targeting the intestine of diabetic rats and systemic lipopolysaccharide influx.

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Task-state skin potential abnormalities can distinguish major depressive disorder and bipolar depression from healthy controls

Lyu,

Huang,

et al. 2024

Transl Psychiatry

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Early detection of bipolar depression (BPD) and major depressive disorder (MDD) has been challenging due to the lack of reliable and easily measurable biological markers. This study aimed to investigate the accuracy of discriminating patients with mood disorders from healthy controls based on task state skin potential characteristics and their correlation with individual indicators of oxidative stress. A total of 77 patients with BPD, 53 patients with MDD, and 79 healthy controls were recruited. A custom-made device, previously shown to be sufficiently accurate, was used to collect skin potential data during six emotion-inducing tasks involving video, pictorial, or textual stimuli. Blood indicators reflecting individual levels of oxidative stress were collected. A discriminant model based on the support vector machine (SVM) algorithm was constructed for discriminant analysis. MDD and BPD patients were found to have abnormal skin potential characteristics on most tasks. The accuracy of the SVM model built with SP features to discriminate MDD patients from healthy controls was 78% (sensitivity 78%, specificity 82%). The SVM model gave an accuracy of 59% (sensitivity 59%, specificity 79%) in classifying BPD patients, MDD patients, and healthy controls into three groups. Significant correlations were also found between oxidative stress indicators in the blood of patients and certain SP features. Patients with depression and bipolar depression have abnormalities in task-state skin potential that partially reflect the pathological mechanism of the illness, and the abnormalities are potential biological markers of affective disorders.

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Visualising reactive oxygen species in live mammals and revealing of ROS-related system

Cited by 4 publications

References 39 publications

The Meridian Tropism and Classification of Red Yeast Rice Investigated by Monitoring Dermal Electrical Potential

The Meridian Tropism and Classification of Red Yeast Rice Investigated by Monitoring Dermal Electrical Potential

Glucose-lowering effects of orally administered superoxide dismutase in type 2 diabetic model rats

Task-state skin potential abnormalities can distinguish major depressive disorder and bipolar depression from healthy controls

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