Visualization of Endothelial Cell Damage Caused by Ultrasonically Induced Microbubble Oscillation Inside a Capillary Phantom

Lipid bubbles combined with low-intensity ultrasound enhance the intratumoral accumulation and antitumor effect of pegylated liposomal doxorubicin in vivo

“…These findings were in accordance with those of previous reports (Unga et al, 2020;Yokoe et al, 2020) wherein increased accumulation and extravasation of macromolecular agents were observed after the combination of LBs and LIUS in normal tissues of mice. Shimizu et al recently visualized the effect of ultrasonically excited LBs in endothelial cells, using a capillary phantom (Shimizu et al, 2020). They showed that the expansion and contraction of LBs led to the increase in local permeability through the loosening of the tight junction between endothelial cells and damage of cell membranes of the endothelial cells.…”