Visuomotor Representations within the Human Primary Motor Cortex: The Elusive Markers of Visuomotor Associative Learning

Taschereau-Dumouchel, Vincent; Hétu, Sébastien

doi:10.1523/jneurosci.5357-11.2012

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…A previous study reported that the SCD group exhibited higher fALFF values than HCs, consistent with our study 46 . The function of preCG is to start the purposeful movement by integrating the information through the sensory‐motor cortex 47 . Increased fALFF values indicated enhanced neuronal connectivity in the left IOG and left preCG in the process of cognitive impairment 48 .…”

Section: Discussionsupporting

confidence: 88%

“…46 The function of preCG is to start the purposeful movement by integrating the information through the sensory-motor cortex. 47 Increased fALFF values indicated enhanced neuronal connectivity in the left IOG and left preCG in the process of cognitive impairment. 48 IPL has a close connection with episodic memory.…”

Section: Altered Functional Patterns Of Dan In Scd and Amcimentioning

confidence: 98%

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Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease

et al. 2023

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Objectives Subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) are known as the preclinical and early stage of Alzheimer's disease (AD). The dorsal attention network (DAN) is mainly responsible for the “top‐down” attention process. However, previous studies mainly focused on single functional modality and limited structure. This study aimed to investigate the multimodal alterations of DAN in SCD and aMCI to assess their diagnostic value in preclinical and early‐stage AD. Methods Resting‐state functional magnetic resonance imaging (MRI) was carried out to measure the fractional amplitude of low‐frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC). Structural MRI was used to calculate the gray matter volume (GMV) and cortical thickness. Moreover, receiver‐operating characteristic (ROC) analysis was used to distinguish these alterations in SCD and aMCI. Results The SCD and aMCI groups showed both decreased ReHo in the right middle temporal gyrus (MTG) and decreased GMV compared to healthy controls (HCs). Especially in the SCD group, there were increased fALFF and increased ReHo in the left inferior occipital gyrus (IOG), decreased fALFF and increased FC in the left inferior parietal lobule (IPL), and reduced cortical thickness in the right inferior temporal gyrus (ITG). Furthermore, functional and structural alterations in the SCD and aMCI groups were closely related to episodic memory (EM), executive function (EF), and information processing speed (IPS). The combination of multiple indicators of DAN had a high accuracy in differentiating clinical stages. Conclusions Our current study demonstrated functional and structural alterations of DAN in SCD and aMCI, especially in the MTG, IPL, and SPL. Furthermore, cognitive performance was closely related to these significant alterations. Our study further suggested that the combined multiple indicators of DAN could be acted as the latent neuroimaging markers of preclinical and early‐stage AD for their high diagnostic value.

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Section: Discussionsupporting

confidence: 88%

Section: Altered Functional Patterns Of Dan In Scd and Amcimentioning

confidence: 98%

Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease

et al. 2023

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“…The precentral gyrus with hypergyrification observed in this study is part of the primary motor cortex, which is relevant to the initiation of movement by integrating information from the sensorimotor cortex [ 74 ]. The large corticospinal neurons typically present in this region [ 75 ], while the dopaminergic projection to the primary motor cortex mediates the biochemical pathway of movement [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

Surface Vulnerability of Cerebral Cortex to Major Depressive Disorder

Peng

Shi

et al. 2015

PLoS ONE

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Major depressive disorder (MDD) is accompanied by atypical brain structure. This study first presents the alterations in the cortical surface of patients with MDD using multidimensional structural patterns that reflect different neurodevelopment. Sixteen first-episode, untreated patients with MDD and 16 matched healthy controls underwent a magnetic resonance imaging (MRI) scan. The cortical maps of thickness, surface area, and gyrification were examined using the surface-based morphometry (SBM) approach. Increase of cortical thickness was observed in the right posterior cingulate region and the parietal cortex involving the bilateral inferior, left superior parietal and right paracentral regions, while decreased thickness was noted in the parietal cortex including bilateral pars opercularis and left precentral region, as well as the left rostral-middle frontal regions in patients with MDD. Likewise, increased or decreased surface area was found in five sub-regions of the cingulate gyrus, parietal and frontal cortices (e.g., bilateral inferior parietal and superior frontal regions). In addition, MDD patients exhibited a significant hypergyrification in the right precentral and supramarginal region. This integrated structural assessment of cortical surface suggests that MDD patients have cortical alterations of the frontal, parietal and cingulate regions, indicating a vulnerability to MDD during earlier neurodevelopmental process.

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“…They found that subjective pleasantness was related to the preCG, right cerebellum, and right inferior frontal gyrus [ 39 ]. The preCG is located at the primary motor cortex, which is required for the initiation of purposeful movements via integration of information sent from the sensorimotor cortex [ 40 ]. Several studies have confirmed the association between psychomotor retardation, poor action planning, and alterations in the preCG [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms

et al. 2018

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Neuroimaging studies have demonstrated that major depressive disorder increases the risk of dementia in older individuals with mild cognitive impairment. We used resting-state functional magnetic resonance imaging to explore the intrinsic coupling patterns between the amplitude and synchronisation of low-frequency brain fluctuations using the amplitude of low-frequency fluctuations (ALFF) and the functional connectivity density (FCD) in 16 patients who had mild cognitive impairment with depressive symptoms (D-MCI) (mean age: 69.6 ± 6.2 years) and 18 patients with nondepressed mild cognitive impairment (nD-MCI) (mean age: 72.1 ± 9.7 years). Coupling was quantified as the correlations between the ALFF values and their associated FCDs. The results showed that the ALFF values in the D-MCI group were higher in the left medial prefrontal cortex (mPFC) and lower in the right precentral gyrus (preCG), and the FCD values were higher in the left medial temporal gyrus (MTG) than those in the nD-MCI group. Further, correlation analyses demonstrated that, in the D-MCI group, the mPFC was negatively correlated with the MTG. These findings may relate to the characteristics of mood disorders in patients with MCI, and they offer further insight into the neuropathophysiology of MCI with depressive symptoms.

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Visuomotor Representations within the Human Primary Motor Cortex: The Elusive Markers of Visuomotor Associative Learning

Cited by 5 publications

References 9 publications

Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease

Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease

Surface Vulnerability of Cerebral Cortex to Major Depressive Disorder

Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms

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