Vital Pulp Therapy An insight over the available literature and future expectations

Hanna, Samer Nagui; Alfayate, Ruth Pérez; Prichard, James

doi:10.14744/eej.2019.44154

Cited by 33 publications

(11 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major drawback of this therapeutic modality is, however, the loss of tooth vitality. More recently, vital pulp therapy has gained much attention, especially on the treatment of immature permanent teeth (4). With the advancement of regenerative dentistry, biomaterials as well as stem cell therapy, which have been utilized to dampen the pulpal inflammation while preserving pulpal vitality (5).…”

Section: Introductionmentioning

confidence: 99%

Single-Cell Transcriptomic Profiling of Human Dental Pulp in Sound and Carious Teeth: A Pilot Study

et al. 2022

View full text Add to dashboard Cite

A comprehensive understanding of dental pulp cellular compositions and their molecular responses to infection are crucial for the advancement of regenerative dentistry. Here, we presented a pilot study of single-cell transcriptomic profiles of 6,810 pulpal cells isolated from a sound human maxillary third molar and three carious teeth with enamel and deep dental caries. We observed altered immune cell compositions of the dental pulp in deep, but not enamel ones. Differential expression analysis revealed up-regulation of several pro-inflammatory, anti-inflammatory, and mineralization-related genes in the immune and stromal cells of the deep dental caries. Making use of an algorithm for predicting cell-to-cell interactions from single-cell transcriptomic profiles, we showed an increase in cell-cell interactions between B cells, plasma cells and macrophages, and other cell types in deep dental caries, including those between TIMP1 (odontoblasts)—CD63 (myeloid cells), and CCL2 (macrophages)—ACKR1 (endothelial cells). Collectively, our work highlighted the single-cell level gene regulations and intercellular interactions in the dental pulps in health and disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Single-Cell Transcriptomic Profiling of Human Dental Pulp in Sound and Carious Teeth: A Pilot Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Vital pulp therapy involves the application of pulp capping materials to promote the formation of a dentin bridge at the root canal orifice after removing the damaged coronal pulp tissue [ 70 ]. However, the severe inflammatory reaction caused by the material is a major reason for the failure of this treatment [ 71 ].…”

Section: Clinical Application Of Cgf In Dpc Regenerationmentioning

confidence: 99%

The effects and potential applications of concentrated growth factor in dentin–pulp complex regeneration

Liu

Wang

et al. 2021

Stem Cell Res Ther

View full text Add to dashboard Cite

The dentin–pulp complex is essential for the long-term integrity and viability of teeth but it is susceptible to damage caused by external factors. Because traditional approaches for preserving the dentin–pulp complex have various limitations, there is a need for novel methods for dentin–pulp complex reconstruction. The development of stem cell-based tissue engineering has given rise to the possibility of combining dental stem cells with a tissue-reparative microenvironment to promote dentin–pulp complex regeneration. Concentrated growth factor, a platelet concentrate, is a promising scaffold for the treatment of dentin–pulp complex disorders. Given its characteristics of autogenesis, convenience, usability, and biodegradability, concentrated growth factor has gained popularity in medical and dental fields for repairing bone defects and promoting soft-tissue healing. Numerous in vitro studies have demonstrated that concentrated growth factor can promote the proliferation and migration of dental stem cells. Here, we review the current state of knowledge on the effects of concentrated growth factor on stem cells and its potential applications in dentin–pulp complex regeneration.

show abstract

“…It is believed that dental biomaterials have revolutionised/caused present-day approaches and treatments in dentistry, specifically in periodontics and endodontics [ 72 ]. Vital pulp therapy, as a modern concept and accepted modality [ 73 ], is grounded on the removal of causative factors which results in the reduction/elimination of inflammation and pathosis of the dental pulp, stimulation of the connective tissue to rebuild itself, and proper haemodynamics in the pulpal tissue [ 73 , 74 ]. Studies have reported that an effective VPT needs alleviation of further injury to the remaining odontoblasts and encouragement of new odontoblasts to differentiate [ 75 ].…”

Section: Biomaterialsmentioning

confidence: 99%

Local Drug Delivery Systems for Vital Pulp Therapy: A New Hope

Parhizkar

Asgary

2021

International Journal of Biomaterials

View full text Add to dashboard Cite

Vital pulp therapy (VPT) is deliberated as an ultraconservative/minimally invasive approach for the conservation of vital pulpal tissues, preservation of dental structure, and maintenance of tooth function in the oral cavity. In VPT, following the exposure of the dental pulp, the environment is prepared for the possible healing and probable refunctionalisation of pulpal connective tissue. However, to succeed in VPT, specific biomaterials are used to cover and/or dress the exposed pulp, lower the inflammation, heal the dental pulp, provoke the remaining odontoblastic cells, and induce the formation of a hard tissue, i.e., the dentinal bridge. It can be assumed that if the employed biomaterial is transferred to the target site using a specially designed micro-/nanosized local drug delivery system (LDDS), the biomaterial would be placed in closer proximity to the connective tissue, may be released in a controlled and sustained pattern, could properly conserve the remaining dental pulp and might appropriately enhance hard-tissue formation. Furthermore, the loaded LDDS could help VPT modalities to be more ultraconservative and may minimise the manipulation of the tooth structure as well as pulpal tissue, which could, in turn, result in better VPT outcomes.

show abstract

Vital Pulp Therapy An insight over the available literature and future expectations

Cited by 33 publications

References 63 publications

Single-Cell Transcriptomic Profiling of Human Dental Pulp in Sound and Carious Teeth: A Pilot Study

Single-Cell Transcriptomic Profiling of Human Dental Pulp in Sound and Carious Teeth: A Pilot Study

The effects and potential applications of concentrated growth factor in dentin–pulp complex regeneration

Local Drug Delivery Systems for Vital Pulp Therapy: A New Hope

Contact Info

Product

Resources

About