2023
DOI: 10.3390/nu15020376
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Vitamin A- and D-Deficient Diets Disrupt Intestinal Antimicrobial Peptide Defense Involving Wnt and STAT5 Signaling Pathways in Mice

Abstract: Vitamin A and D deficiencies are associated with immune modulatory effects and intestinal barrier impairment. However, the underlying mechanisms remain unclear. C57BL/6J mice were fed either a diet lacking in vitamin A (VAd), vitamin D (VDd) or a control diet (CD) for 12 weeks. Gut barrier function, antimicrobial peptide (AMP) defense and regulatory pathways were assessed. VAd mice compared to CD mice showed a reduced villus length in the ileum (p < 0.01) and decreased crypt depth in the colon (p < 0.05)… Show more

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Cited by 8 publications
(15 citation statements)
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“…In regions with a mucus coating, the secreted AMPs are retained within the mucus, providing a combined physical and chemical barrier against microbial infection [ 162 ]. Specialized Paneth cells found in the crypts of Lieberkühn secrete AMPs in the intestines [ 30 ], whereas in the lungs, AMPs are secreted into the airway surface liquid (ASL), a thin layer of fluid rich in mucin, and are produced by the submucosal glands of the respiratory epithelium [ 19 , 163 , 164 , 165 ].…”
Section: Epithelial Secretion Of Antimicrobial Peptidesmentioning
confidence: 99%
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“…In regions with a mucus coating, the secreted AMPs are retained within the mucus, providing a combined physical and chemical barrier against microbial infection [ 162 ]. Specialized Paneth cells found in the crypts of Lieberkühn secrete AMPs in the intestines [ 30 ], whereas in the lungs, AMPs are secreted into the airway surface liquid (ASL), a thin layer of fluid rich in mucin, and are produced by the submucosal glands of the respiratory epithelium [ 19 , 163 , 164 , 165 ].…”
Section: Epithelial Secretion Of Antimicrobial Peptidesmentioning
confidence: 99%
“…Two main AMPs are transcribed from human cathelicidin antimicrobial peptide ( CAMP ) and human β-defensin 2/defensin-β4 ( HBD2 / DEFB4 ) [ 19 ]. The VDR binds to vitamin D response elements on the proximal CAMP and HBD2 promoter sequences [ 19 , 30 , 170 , 171 ], located 507 and 1231 bp upstream of their transcription initiation sites, respectively [ 172 ]. While these genes are induced by vitamin D in human cells of epithelial or myeloid origin, the same process does not seem to occur in cells derived from mice [ 19 , 173 ].…”
Section: Epithelial Secretion Of Antimicrobial Peptides: Vitamin D/vd...mentioning
confidence: 99%
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