Vitamin A- and E-based liposomal tear replacement in pediatric patients

Guagliano, Rosanna; Spallone, Laura; Lombardo, Sara; Trabucco, Paolo; Bertone, Chiara; Barillà, Donatella; Tinelli, Carmine; Bianchi, Paolo Emilio

doi:10.23736/s0026-4946.17.05092-7

Cited by 2 publications

(1 citation statement)

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“…No studies exploring the effects of topical vitamin C administration are currently available. Two formulations of vitamin E and coenzyme Q10 have been evaluated in four different studies on different groups of DED patients (patients receiving cataract surgery, women in menopause receiving antidepressants, subjects exposed to local irritants, children) [67][68][69][70]. All the studies showed that these treatments are effective in ameliorating OS homeostasis, tear stability [67][68][69][70] and in restoring the normal corneal innervation under confocal microscopy [67].…”

Section: Clinical Studies On Topical Supplementationmentioning

confidence: 99%

A Review of Topical and Systemic Vitamin Supplementation in Ocular Surface Diseases

et al. 2021

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In the homeostasis of the ocular surface, vitamins play a critical role in regulating inflammatory responses and promoting cell differentiation, development and correct function. Systemic vitamin supplementation has been available for many decades; in recent years, thanks to pharmacological advancements, topical vitamin delivery has also become available in an attempt to better treat ocular surface disease (OSD) and dry eye disease (DED). In this paper, we reviewed the current evidence on the role of vitamin supplementation in OSD and DED. We originally searched the PubMed archive, inspected the references and restricted the search to pertinent papers. The body of evidence was evaluated using the amelioration of both signs and symptoms as the outcome, when available. We found that in patients with vitamin deficiency, systemic supplementation of Vitamin A is effective in treating OSD, reducing both DED signs and symptoms. Additionally, systemic supplementation of vitamin D is useful in reducing DED symptoms and increasing tear volume. Vitamin A is also effective in reducing DED signs and symptoms when administered locally. The efficacy of supplementation with other vitamins is still not fully proven. In conclusion, the inclusion of vitamins into the treatment strategies for OSD and DED allows for better treatment customization and better outcomes in these patients.

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Section: Clinical Studies On Topical Supplementationmentioning

confidence: 99%

A Review of Topical and Systemic Vitamin Supplementation in Ocular Surface Diseases

et al. 2021

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Dry Eye Disease and Vitamins: A Narrative Literature Review

Hyon

Han

2022

Applied Sciences

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Dry eye disease (DED) is a major public health problem worldwide that seriously impairs the quality of life, reduces work productivity, and poses significant economic burden. In DED, tear film instability or hyperosmolarity activates a self-perpetuating vicious cycle that may aggravate ocular surface inflammation and damage. Thus, treatment approaches should focus on interrupting this cycle and ameliorating inflammation. In addition to anti-inflammatory medications, such as corticosteroids, cyclosporine, and lifitegrast, nutrients with anti-inflammatory and anti-oxidative properties may also be effective for the treatment of DED. Evidence indicates that vitamin deficiencies may be associated with an increased risk of DED and that vitamin supplementation can be an effective treatment for DED. In the present review, we introduce the results of clinical and experimental studies on the association between vitamin deficiencies and DED. The potential efficacy of systemic and topical supplementation in the treatment of DED is also discussed.

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Vitamin A- and E-based liposomal tear replacement in pediatric patients

Cited by 2 publications

References 0 publications

A Review of Topical and Systemic Vitamin Supplementation in Ocular Surface Diseases

A Review of Topical and Systemic Vitamin Supplementation in Ocular Surface Diseases

Dry Eye Disease and Vitamins: A Narrative Literature Review

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