Vitamin B6 as a novel risk biomarker of fractured ankles

Abstract

Ankle fractures are the most common intra-articular fractures. Osteoporosis is a common and frequent disease among the elderly with a poor prognosis and high risk of fractured ankles. However, the relationship between vitamin B6 and the incidence of fractured ankles in patients with osteoporosis is unclear. A total of 101 patients with osteoporosis were recruited. Clinical and followed-up information was recorded. And the vitamin B6, albumin, globulin, and hemoglobin in the blood were tested. Pearson's chi-squared and spearman test were performed to analyze the correlation between fractured ankles and relative parameters. Univariate and multivariate logistic regression, receiver operating characteristic curve analysis, univariate and multivariate Cox proportional hazards regression analysis, and Kaplan–Meier method were also performed. There exist strong relation between the expression level of vitamin B6 and fractured ankle ( P < .001). The expression of vitamin B6 [Odd ratio (OR) = 12.071, 95% confidence interval (CI): 4.69–31.143, P < .001] has a clear correlation with whether the patients have fractured ankles via the univariate logistic regression analysis. In terms of multivariate logistic regression level, vitamin B6 (OR = 15.384, 95% CI:5.195–45.556, P < .001) was significantly associated with fractured ankle. In addition, expression level of vitamin B6 [hazard ratio (HR) = 11.684, 95% CI: 6.419–21.267, P < .001] was significantly associated with Maintenance time from recovery to recurrence (MRTT) of patients with osteoporosis. Enhanced vitamin B6 is significantly correlated with the poor prognosis of patients with osteoporosis and the increasing incidence of fractured ankles.

Calcium carbonate alleviates calcium deficiency through changes in the gut microbiota and metabolites

“…Vitamin B6 is necessary for the cross-linking of lysine oxidase collagen, which plays an important role in maintaining bone mass. Meanwhile, vitamin B6 de ciency reduces the concentration of cross-linking intermediates and disrupts collagen cross-linking in bone [37]. Enrichment of L-lysine has previously been observed in osteopenia [38].This supports the upregulation of L-methylphenidate involved in lysine degradation in plasma differentials.…”

“…Estrogen is one of the main hormones regulating bone metabolism [36]. Estrogen de ciency affects bone cell-mediated remodeling, reducing bone mass and damaging bone microstructure [37]. Vitamin B6 de ciency may also be a risk factor for bone loss.…”

A Prediction Model for Osteoporosis Risk Using a Machine-Learning Approach and Its Validation in a Large Cohort

“…The other study has also demonstrated that they are positively associated with a fractured ankle. 40 Therefore, vitamin B6 intake is potentially related to bone health, and adults need to consume foods rich in vitamin B6. Vitamin B6-rich foods are beef liver, tuna, salmon, chicken breast, chickpeas, bananas, cottage cheese, nuts, and onion.…”

Chondroitin sulfate alleviates osteoporosis caused by calcium deficiency by regulating lipid metabolism

“…We found that the normally-fed rats’ plasma testosterone levels were significantly higher than those in the other three groups, the decrease of testosterone low calcium for a long time, Recovery may not be achieved by calcium supplementation and the addition of chondroitin sulfate [ 57 ]. Estrogen deficiency affects bone cell-mediated remodeling, reducing bone mass and damaging bone microstructure [ 58 ]. Microbiota play a significant role in lipid homeostasis by fermenting dietary fiber for production.…”