Vitamin C in the Blood and Urine of the Newborn and in the Cord and Maternal Blood

Hamil, Brenton M.

doi:10.1001/archpedi.1947.02030010430002

Cited by 15 publications

(9 citation statements)

References 45 publications

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“…The general condition of the mothers at definitely dependant on the diet and the time of delivery was good or moderat-nutritional condition of the mothers durely good. A corresponding comparison ing pregnancy (6). The placenta conveys with the premature infants was not pos-vitamins B and C from the mother's blood sible, as they were usually born elsewhere, to the fetus, but evidently their transand records of the mother's condition portation in the opposite direction is pretherefore often limited.…”

Section: Resultsmentioning

confidence: 99%

The Vitamin B₁, B₂ and C Content in Urine of Premature and Fullterm Newborn Infants

Markkanen

Vanha‐Perttula

1959

Acta Paediatrica

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Summary The daily excretion of vitamins B1, B2, and C was studied in 24 newborn full‐term infants during the three first days of life, and in 15 premature infants on three successive days of treatment. No correlation was observed between the mothers' state of health during pregnancy, the number of previous births and the presence of certain diseases, with the daily excretion of vitamin B1, B2 and C in the urine of newborn full‐term infants.

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Section: Resultsmentioning

confidence: 99%

The Vitamin B₁, B₂ and C Content in Urine of Premature and Fullterm Newborn Infants

Markkanen

Vanha‐Perttula

1959

Acta Paediatrica

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“…Ascorbic acid levels, like those of other water-soluble vitamins, decline progressively during pregnancy, with fetal levels higher than maternallevels (Hamil et al, 1947;Mason and Rivers, 1971). An increased incidence ofpremature births was related to low intakes and low serum levels of ascorbic acid (Martin et al, 1957).…”

Section: Association Of Fetal Growth W"h Maternal Nutrmonmentioning

confidence: 99%

Association of Fetal Growth with Maternal Nutrition

Metcoff

1978

Principles and Prenatal Growth

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“…However, under certain environmental conditions (metabolic changes during delivery, systemic inflammation in neonates), signaling pathways which are not NF B-dependent may be predominant for the production of pro-inflammatory cytokines including complement system or nuclear oligomerization domains [34] . Moreover, vitamin C concentrations in cord plasma are higher than maternal levels, and plasma concentrations in term infants considerably fall within the first 24 h of life [15,35] . To clarify this, further studies are needed to compare cord blood and neonatal peripheral blood samples for its reactivity to vitamin C.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory Effect of Vitamin C on Intracytoplasmic Cytokine Production in Neonatal Cord Blood Cells

et al. 2006

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Background: Vitamin C (ascorbic acid) is an essential water-soluble antioxidant in cells and plasma. Besides metabolic functions, vitamin C is also known to contribute to immune homeostasis. Recently, it has been demonstrated that vitamin C has an inhibitory effect on the expression of pro-inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) in adult whole blood cells in vitro. It has been postulated that vitamin C might be an interesting compound for modulation of an over-exuberant immune response, e.g., in patient cohorts susceptible for the development of systemic inflammatory response syndrome such as neonates. It was the aim of this study to investigate the modulatory effects of vitamin C on the production of inflammatory mediators in neonatal cord blood cells. Methods: The intracytoplasmic production of pro-inflammatory cytokines in neonatal cord blood cells stimulated with lipopolysaccharide or phorbol 12-myristate 13-acetate/ionomycin was assessed by flow-cytometry. Results: In contrast to our previous observations from adult whole blood cells, 20 mM vitamin C mildly stimulated the percentage of neonatal monocytes producing IL-6 after lipopolysaccharide stimulation (e.g., 11.3% increase compared to control, p = 0.005). In the presence of 20 mM vitamin C, even a stronger stimulatory effect was noted for the percentage of IL-8 (e.g., 46.7% increase, p < 0.001) and TNF-α producing neonatal monocytes (e.g., 69.2% increase, p = 0.004; n = 20). In accordance with adult data, the percentage of neonatal lymphocytes producing IL-2 after phorbol 12-myristate 13-acetate/ionomycin stimulation was dose-dependently reduced (e.g., 41.3% inhibition, p = 0.001, 20 mM vitamin C), while the percentage of TNF-α producing lymphocytes was mildly stimulated (e.g., 20.8% increase, p = 0.003, 20 mM vitamin C). Conclusions: Interestingly, vitamin C was demonstrated to enhance pro-inflammatory responses in CD14⁺ cord blood cells while only intracellular IL-2 production in CD3⁺ cells was diminished. These data suggest that vitamin C differentially influences intracytoplasmic cytokine production in adults and neonates, and further studies are needed to elucidate the underlying mechanisms of this selective immunomodulation.

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Vitamin C in the Blood and Urine of the Newborn and in the Cord and Maternal Blood

Cited by 15 publications

References 45 publications

The Vitamin B₁, B₂ and C Content in Urine of Premature and Fullterm Newborn Infants

The Vitamin B₁, B₂ and C Content in Urine of Premature and Fullterm Newborn Infants

Association of Fetal Growth with Maternal Nutrition

Immunomodulatory Effect of Vitamin C on Intracytoplasmic Cytokine Production in Neonatal Cord Blood Cells

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Vitamin C in the Blood and Urine of the Newborn and in the Cord and Maternal Blood

Cited by 15 publications

References 45 publications

The Vitamin B1, B2 and C Content in Urine of Premature and Fullterm Newborn Infants

The Vitamin B1, B2 and C Content in Urine of Premature and Fullterm Newborn Infants

Association of Fetal Growth with Maternal Nutrition

Immunomodulatory Effect of Vitamin C on Intracytoplasmic Cytokine Production in Neonatal Cord Blood Cells

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Product

Resources

About

The Vitamin B₁, B₂ and C Content in Urine of Premature and Fullterm Newborn Infants

The Vitamin B₁, B₂ and C Content in Urine of Premature and Fullterm Newborn Infants