Vitamin C induced DNA cleavage using curcumin loaded Fe3O4-silane magnetic nanoparticles

Abstract

The loading and unloading of a drug into a nanoparticle is the first stage in the delivery of a nanodrug. This work investigates the loading of curcumin via soft hydrolysis of silane using iron oxide-silane core-shell nanoparticles. Additionally, the study examines the sustained release of curcumin from the core-shell nanoparticles over a period of 70 hours at a physiological pH. The release ability is studied using absorption spectral technique. The interaction of DNA is studied using emission spectral technique. Drug delivery applications should involve interactions between the released drug and the biomolecules of the biological systems. Therefore, this system is used to study the interaction between curcumin and DNA and vitamin C-induced cleavage.