Vitamin C regulates skeletal muscle post-injury regeneration by promoting myoblast proliferation through its direct interaction with the Pax7 protein

Abstract

This study shows that VC binds to Pax7 to up-regulate the expression and nuclear translocation of Pax7, thereby up-regulating the expression of Myf5 to promote proliferation of C2C12 myoblasts and mice skeletal muscle post-injury regeneration.