Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine

Wu, Min-Sheng; He, Meina; Kang, Youmin

doi:10.1080/09540105.2017.1406459

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…We further investigated the effect of L-EPS as the adjuvant on enhancement of antibody responses of foot-and-mouth disease (FMD) vaccine in a mouse model. FMD is a highly contagious and economically important disease of cloven-hoofed livestock (Wu et al, 2017). Studies showed that humoral immune responses are important in protection against FMD (Li et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo

Xiu

Zhang

et al. 2018

Food and Agricultural Immunology

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Exopolysaccharides act as mediators of cross-talk between probiotics and the host. Here, we found that EPS derived from probiotic Lactobacillus casei WXD030 strain (L-EPS) could modulate immune responses in vitro and in vivo. L-EPS could significantly enhance the proliferation and phagocytic activity as well as induce the production of NO, TNF-α, IL-1β and IL-6 in RAW264.7 cells. Furthermore, L-EPS could induce the maturation of BMDCs. In addition, L-EPS could largely increase the titres of OVA-specific antibodies and markedly enhanced T cell proliferation. Notably, L-EPS also increased expression of IL-4 and INF-γ expression in CD4 + T cells. Consistently, when used as an adjuvant in vivo with the foot-and-mouth disease vaccine, L-EPS largely enhanced the FMDVspecific antibody production. Collectively, these results suggested that L-EPS derived from probiotic L. casei strain had adjuvant activity, which may be a safe and efficacious adjuvant candidate suitable for a wide spectrum of prophylactic and therapeutic vaccines.

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Section: Discussionmentioning

confidence: 99%

“…Vaccination has been proved to be the most cost-effective strategy for controlling a wide variety of infectious diseases (Wu, He, & Kang, 2017;Zhang et al, 2018). Various approaches have been developed recently in order to improve vaccine potency, particularly with the respect to choose of a better adjuvant.…”

Section: Introductionmentioning

confidence: 99%

Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo

Xiu

Zhang

et al. 2018

Food and Agricultural Immunology

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“…Several studies revealed that vitamin C has immunomodulatory functions (4,8,19,22,23). Vitamin C supplementation to animals enhanced phagocytosis of macrophages and proliferated helper T cells and B cells (4,8).…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin C supplementation on the blood oxidative stress and antibody titre against Histophilus somni vaccination in calves

Otomaru

Oishi

Fujimura

et al. 2020

Journal of Veterinary Research

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IntroductionThe purpose of this study was to determine the effects of vitamin C supplementation on blood oxidative stress biomarkers and antibody response to vaccination in calves.Material and methodsThirty-four clinically healthy 2 week old Japanese Black calves were randomly assigned to two groups. Seventeen calves formed the VC group which received 1,000 mg of vitamin C daily from 2 to 8 weeks of age, and the other 17 calves of the control group did not receive supplementation. All calves received an inactivated Histophilus somni vaccine at 4 and 8 weeks of age. Blood samples were taken at 2, 4, 8 and 12 weeks of age.ResultsThe concentration of the serum reactive oxygen metabolites (d-ROMs), and the oxidative stress index (OSI), which is calculated from the d-ROMs and biological antioxidant potential, were significantly lower at 8 weeks of age in the VC group than in the control group (P < 0.05). The antibody titres to H. somni in the VC group were significantly higher than those in the control group at 12 weeks of age after the second vaccination (P < 0.05).ConclusionVitamin C supplementation to calves may reduce oxidative stress and enhance the antibody production after vaccination with H. somni.

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“…Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin [92]. Several investigations indicated that vitamin C is an essential factor for the anti-viral immune responses through increasing production of anti-viral cytokine, interferon (IFN)-α/β especially against influenza A virus (H3N2) at the early time of infection [93], [94]. Similarly, in another animal study, vitamin C deficiency increased the lung pathology of influenza virus-infected gulo-/-mice.…”

Section: Vitamin Cmentioning

confidence: 99%

The Role of Nutrients in Supporting The Immune System Against Viral Infection; Newly Emerged Coronavirus (COVID19): A Narrative Review

Farag

Baqi

Hussein

et al. 2020

KJAR

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Balanced nutrition is vital for peak performance of immune function, especially when a global pandemic is emerging, and there is major lack in approved treatments for it. Many nutrients and their abundance in cells induce immune function. We performed a narrative review to describe existing literature with regard to role of nutrients in supporting the immune system against viral infection including coronavirus (SARS-COV-2). PubMed, Scopus and Google Scholar databases were searched for relevant articles. This review represents a picture of the current state of the art. In particular, we classified the nutrients by means of their types, abundance, importance and possible antiviral effects in immune system. The macronutrients such as carbohydrates, lipids, and proteins are essential for cells to generate energy and participate in immune function as well. However, unbalanced diet with high levels of macromolecules could lead to chronic diseases that impair the body’s immune abilities. The micronutrients including vitamins and minerals participate in immune system on a bigger scale that almost all body’s immune mechanism depends on the expressions of micronutrients. Vitamins improve immune responses. Some vitamins include A, D, K, B, and C enroll in antiviral mechanism of the immune cells. A group of trace elements including zinc, copper, selenium, magnesium, manganese, and iron are heavily contributed in maintaining body’s immunity. The susceptibility toward the infectious diseases is highly elevated in cases of their deficiencies. Besides their antiviral roles, vitamins such as E and C with minerals in the cells adopt antioxidant properties that help immune cells to fight oxidative stress in the cells. Nevertheless, the high levels of minerals such as iron could threat the immune system by growing the oxidative stress. So, maintaining rich and balanced nutrition could improve body’s immune function, and possibly prevent viral infections including COVID-19.

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Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine

Cited by 8 publications

References 34 publications

Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo

Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo

Effects of vitamin C supplementation on the blood oxidative stress and antibody titre against Histophilus somni vaccination in calves

The Role of Nutrients in Supporting The Immune System Against Viral Infection; Newly Emerged Coronavirus (COVID19): A Narrative Review

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