Vitamin D (1,25-(OH)2D3) regulates the gene expression through competing endogenous RNAs networks in high glucose-treated endothelial progenitor cells

Yü, Ping; Song, Haiyan; Gao, Jiaxin; Li, Bo; Liu, Ying; Wang, Yanhe

doi:10.1016/j.jsbmb.2019.105425

Cited by 13 publications

(3 citation statements)

References 55 publications

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“…Supplementation with vitamin D could improve the function of endothelial cells in in type 2 diabetes by affecting the expression profiles of 1,791 mRNAs, 2,726 lncRNAs, 205 circRNAs, and 45 miRNAs, and these differentially expressed RNAs were related to matrix metalloproteinase and guanosine triphosphatase activities, specific signaling pathways, and components of actin, extracellular matrix, or adherens junctions (56). However, the role of these natural products, nutrients, and supplements on ncRNAs requires further study in infertility.…”

Section: Vitamin Dmentioning

confidence: 99%

Drug substitution and adjuvant therapy in patients with genetics related infertility: A review

Jin

Zhou

et al. 2023

DD&T

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With the in-depth study of the human genome and the increasing popularity of gene sequencing, it has been gradually confirmed that genetics can play a crucial role in infertility. To provide references for clinical treatment, we have focused on genes and drug therapy for genetic infertility. This review recommends adjuvant therapy and drug substitution. Examples of these therapies include antioxidants (such as folic acid, vitamin D, vitamin E, inositol, coenzyme Q10 etc.), metformin, anticoagulants, levothyroxine, dehydroepiandrosterone, glucocorticoids, and gonadotropins etc. Based on the pathogenesis, we provide an overview of the current knowledge, including randomized controlled trials and systematic reviews, and predict potential target genes and signaling pathways, proposing possible future strategies for the use of targeted drugs to treat infertility. Non-coding RNAs are anticipated to become a novel target for the treatment of reproductive illnesses since they have a significant role in controlling the occurrence and development of reproductive diseases.

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Section: Vitamin Dmentioning

confidence: 99%

Drug substitution and adjuvant therapy in patients with genetics related infertility: A review

Jin

Zhou

et al. 2023

DD&T

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“…Yu et al compared the expression profiles of miRNAs, lncRNAs, mRNAs and circRNAs, between 1,25-(OH) 2 D 3treated endothelial progenitor cells (EPCs) and control cells. They used bioinformatics analyses to identify differentially expressed RNAs and constructed the competing endogenous RNA (ceRNA) networks with Cytoscape software [33]. Zhang et al investigated the effect of 1,25-dihydroxy-vitamin D3 (1,25-(OH) 2 D 3 ) on primary chondrocytes cultured from patients with an osteoarthritis protein-protein interaction (PPI) by a PPI network [34].…”

Section: Ai In Research On the Influence Of Nutrients On Physiological And Pathophysiological Functionsmentioning

confidence: 99%

Artificial Intelligence in Nutrients Science Research: A Review

Sak

Suchodolska

2021

Nutrients

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Artificial intelligence (AI) as a branch of computer science, the purpose of which is to imitate thought processes, learning abilities and knowledge management, finds more and more applications in experimental and clinical medicine. In recent decades, there has been an expansion of AI applications in biomedical sciences. The possibilities of artificial intelligence in the field of medical diagnostics, risk prediction and support of therapeutic techniques are growing rapidly. The aim of the article is to analyze the current use of AI in nutrients science research. The literature review was conducted in PubMed. A total of 399 records published between 1987 and 2020 were obtained, of which, after analyzing the titles and abstracts, 261 were rejected. In the next stages, the remaining records were analyzed using the full-text versions and, finally, 55 papers were selected. These papers were divided into three areas: AI in biomedical nutrients research (20 studies), AI in clinical nutrients research (22 studies) and AI in nutritional epidemiology (13 studies). It was found that the artificial neural network (ANN) methodology was dominant in the group of research on food composition study and production of nutrients. However, machine learning (ML) algorithms were widely used in studies on the influence of nutrients on the functioning of the human body in health and disease and in studies on the gut microbiota. Deep learning (DL) algorithms prevailed in a group of research works on clinical nutrients intake. The development of dietary systems using AI technology may lead to the creation of a global network that will be able to both actively support and monitor the personalized supply of nutrients.

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“…Additionally, Schröder-Heurich et al demonstrated that 1,25(OH)2D increased endothelial progenitor adhesion by alleviating the inflammatory signals of TNF-α in vitro (Table 1) [126]. [127]. Differentially expressed RNA influenced the activity of MMP and guanosine-5'-triphosphatase, which are related to EPC migration.…”

Section: The Influence Of Vitamin D On Epcs In Vascular Calcificationmentioning

confidence: 99%

The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification

Hou

Zheng

et al. 2020

IJMS

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Vascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors. Recent observations implied a role for mesenchymal stem cells and endothelial progenitor cells in vascular calcification. Mesenchymal stem cells reside in the bone marrow and the adventitial layer of arteries. Endothelial progenitor cells that originate from the bone marrow are an important mechanism for repairing injured endothelial cells. Mesenchymal stem cells may differentiate osteogenically by inflammation or by specific stimuli, which can activate calcification. However, the bioactive substances secreted from mesenchymal stem cells have been shown to mitigate vascular calcification by suppressing inflammation, bone morphogenetic protein 2, and the Wingless-INT signal. Vitamin D deficiency may contribute to vascular calcification. Vitamin D supplement has been used to modulate the osteoblastic differentiation of mesenchymal stem cells and to lessen vascular injury by stimulating adhesion and migration of endothelial progenitor cells. This narrative review clarifies the role of mesenchymal stem cells and the possible role of vitamin D in the mechanisms of vascular calcification.

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Vitamin D (1,25-(OH)2D3) regulates the gene expression through competing endogenous RNAs networks in high glucose-treated endothelial progenitor cells

Cited by 13 publications

References 55 publications

Drug substitution and adjuvant therapy in patients with genetics related infertility: A review

Drug substitution and adjuvant therapy in patients with genetics related infertility: A review

Artificial Intelligence in Nutrients Science Research: A Review

The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification

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