2004
DOI: 10.1359/jbmr.0301240
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Vitamin D and Calcium Supplementation Prevents Osteoporotic Fractures in Elderly Community Dwelling Residents: A Pragmatic Population-Based 3-Year Intervention Study

Abstract: This study of 9605 community-dwelling residents supports that vitamin D and calcium supplementation may prevent osteoporotic fractures in elderly in a northern European region known to be deficient in vitamin D, especially during winter periods. Introduction:We evaluated the effect of two programs for the prevention of osteoporotic fractures leading to acute hospital admission in a population of elderly community-dwelling residents. Materials and Methods: This was a factorial, cluster-randomized, pragmatic, in… Show more

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Cited by 324 publications
(214 citation statements)
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“…At week 12, control group n ¼ 31; HCM n ¼ 27. 20 mg vitamin D reported a 16% fracture reduction, 40 and recent meta-analyses confirm the need for additional calcium with vitamin D supplementation to prevent bone loss and possibly fractures in people aged 50 years and older. 20,41,42 In conclusion, the addition of calcium and vitamin D fortified milk to the diet of postmenopausal Chinese women significantly reduced bone resorption, lowered PTH levels and improved vitamin D status within 2-8 weeks.…”
Section: Discussionmentioning
confidence: 95%
“…At week 12, control group n ¼ 31; HCM n ¼ 27. 20 mg vitamin D reported a 16% fracture reduction, 40 and recent meta-analyses confirm the need for additional calcium with vitamin D supplementation to prevent bone loss and possibly fractures in people aged 50 years and older. 20,41,42 In conclusion, the addition of calcium and vitamin D fortified milk to the diet of postmenopausal Chinese women significantly reduced bone resorption, lowered PTH levels and improved vitamin D status within 2-8 weeks.…”
Section: Discussionmentioning
confidence: 95%
“…Heaney et al [10] established that optimal calcium absorption occurs with a 25(OH)D level greater than 32 ng/mL. Some clinical trials [11][12][13][14], though not all of them [15], have suggested that the most protection from fracture comes from a 25(OH)D level greater than 30 ng/mL. Given the presented evidence, an optimal 25(OH)D should be at least 32 ng/mL to prevent secondary hyperparathyroidism and fracture.…”
Section: Definition Of Vitamin D Insufficiencymentioning
confidence: 99%
“…However, the reviewers identified only 1 RCT that compared the effect of sex on the response to treatment, 17 and therefore graded as insufficient the evidence from this RCT that calcium and vitamin D3 decreased the risk of fracture in elderly women but not in elderly men. 18 Differences in response to treatment according to race or ethnicity were also evaluated as is common in analyses of population subgroups.…”
Section: Summary Of Ahrq's Comparative Effectiveness Review Of Treatmmentioning
confidence: 99%