Vitamin D and depression

Parker, Gordon; Brotchie, Heather; Graham, Rebecca

doi:10.1016/j.jad.2016.08.082

Cited by 221 publications

(141 citation statements)

References 32 publications

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“…67 The role of vitamin D in mood and neurodegenerative disorders might shed light on the involvement of the central nervous system in the activity of this fundamental hormone-like molecule. 57,[68][69][70][71][72] Further research is needed to clarify this issue.…”

Section: Role In Innate Immunitymentioning

confidence: 99%

“…154,155 Vitamin D should play a regulatory role in gut immunology, which has been recently reviewed. 57,[156][157][158] Its activity on hypersensitive reactions, and more commonly on allergy, may come from the evidence-somewhat controversialthat vitamin D deficiency, particularly in a pediatric population, would be associated with challengeproven food allergy in the first year of life. [159][160][161] This evidence was contradicted by more recent reports, however.…”

Section: Role In Acquired and Regulatory Immunitymentioning

confidence: 99%

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The Role of Vitamin D in the Immune System as a Pro-survival Molecule

Chirumbolo

Bjørklund

Sboarina

et al. 2017

Clinical Therapeutics

106

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Section: Role In Innate Immunitymentioning

confidence: 99%

Section: Role In Acquired and Regulatory Immunitymentioning

confidence: 99%

The Role of Vitamin D in the Immune System as a Pro-survival Molecule

Chirumbolo

Bjørklund

Sboarina

et al. 2017

Clinical Therapeutics

106

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“…Furthermore, there is increasing evidence of an association between vitamin D deficiency, or insufficiency, and depression [31,32].…”

Section: Seasonal Variations In Sf-36 Scoresmentioning

confidence: 99%

Health-related quality of life in young women starting hormonal contraception: a pilot study

Kristjánsdóttir

Sundelin

Naessén

2018

The European Journal of Contraception & Reproductive Health

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Objectives: Our purpose was to study whether there is a difference in self-rated health-related quality of life (HRQOL) and changes in HRQOL perception after 3 months of hormonal contraceptive use in adolescents. Seasonal variations in symptoms of depression were also studied. Methods: A test group (T1) (n ¼ 193) and a selected control group (n ¼ 238) of women aged 14-20 years who were visiting a young person's clinic completed the 36-item short-form health survey (SF-36) and answered additional questions on menstrual history and pattern, need for menstrual pain relief medication, and other regular medication. The test group was reassessed after 3 months of hormonal contraception (T2). Seasonal variations in reported SF-36 scores were studied for the whole group. Results: The selected control group and test group at T1 were similar with regard to age at menarche and menstrual pattern. The duration of bleeding and use of painkillers were significantly reduced and the impact on everyday life was significantly improved after 3 months of hormonal contraception (p ¼ .000, two-tailed). No changes in HRQOL or symptoms of possible depression were found after 3 months of hormonal contraception. The highest prevalence odds ratio for possible depression (SF-36 mental health scale score 48), adjusted for group, season and age, for spring vs winter, was 2.15 (95% confidence interval 0.95, 4.85). Conclusions: After 3 months of hormonal contraception both the number of days of menstrual bleeding and the use of medication to relieve menstrual pain were reduced, but there were no significant changes in self-rated HRQOL perception. Seasonal effects on HRQOL were reported. ARTICLE HISTORY

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“…2) The association between vitamin D status and depression is more likely to be evident when vitamin D deficient or insufficient (vs. sufficient) (Parker, Brotchie, & Graham, 2017), and serum vitamin D levels may not have a strong relationship with depressive symptoms when the levels are optimal or suboptimal (Shin et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…4) The effect of vitamin D supplementation on depressive symptoms was small and statistically insignificant in trials of non-clinically depressed participants (Shaffer et al, 2014). 5) Differences in methodological approaches such as differences in characteristics of study population, season of blood collection, assays used for measurement of serum 25(OH)D levels, reference categories of vitamin D concentration, instruments used for assessment of depression (self-reported symptom scale versus diagnostic interviews), conceptualization of depression (depressive symptoms continuum or "caseness" of depression), regression techniques/ types, and covariates adjusted for in regression analyses, were pointed out by many investigators as possible explanations for inconsistent results (Anglin et al, 2013;Ju et al, 2013;Parker et al, 2017). 6) The heterogeneity of depression may justify why low serum 25(OH)D levels may be relevant only in specific subgroups of depressed patients (Milaneschi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Levels and Depressive Symptoms’ Severity Among University Employees in Lebanon

Jaalouk

Boumosleh

Fatayri

2018

GJHS

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Background: Despite the evidence that the association between serum vitamin D level and susceptibility to depression is altered by ethnicity and vitamin D receptor gene polymorphisms, high prevalence of vitamin D deficiency, and parallel substantial burden of depression among Middle Eastern/ Arab adult populations, research exploring whether low serum vitamin D level is associated with increased risk of depression among Arab adult populations is almost non-existent.Objective: This study aims to investigate the relationship between serum vitamin D levels and severity of depressive symptoms among a sample of healthy Lebanese adults, controlling for multiple confounders.Methods: A total of 351 employees at a private university in Lebanon were surveyed. Information about sociodemographic, lifestyle habits, medical/ family history; and depressive symptoms were collected using a background questionnaire, international physical activity questionnaire -short form, and Patient Health Questionnaire, respectively. Anthropometric measurements and fasting blood samples were collected using standard methods. Serum 25-hydroxyvitamin D [25(OH)D] levels were measured by means of ELISA. Multiple linear regression analyses were conducted. A p-value of less than 0.05 was considered statistically significant.Results: Sample mean age was 42.36 years. In the fully adjusted model, higher depression scores were found to be border-line significantly (p= 0.058) associated with lower serum 25-(OH)D levels and significantly associated with younger age, female sex, lower income, chronic illness diagnosis, family history of mental illness, number of stressful life events, and intake of antidepressants. Conclusion:We did not find any significant independent association between serum 25(OH)D levels and severity of depressive symptoms in a sample of Lebanese employees of a private university.

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Vitamin D and depression

Cited by 221 publications

References 32 publications

The Role of Vitamin D in the Immune System as a Pro-survival Molecule

The Role of Vitamin D in the Immune System as a Pro-survival Molecule

Health-related quality of life in young women starting hormonal contraception: a pilot study

Vitamin D Levels and Depressive Symptoms’ Severity Among University Employees in Lebanon

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