Vitamin D and its positive effect on the PTH/vitamin D/calcium-FGF23/klotho/phosphorus axis in kidney transplant recipients

Basurto, Lourdes; Balcázar-Hernández, Lourdes; Manuel‐Apolinar, Leticia; Vargas‐Ortega, Guadalupe; González-Virla, Baldomero; Reza-Albarrán, Alfredo; Jiménez, María del Carmen Martínez; Ordaz, José Luis Martínez; Mendoza‐Zubieta, Victoria

doi:10.20960/nh.04415

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…The FGF23 gene is a member of a large family of fibroblast growth factors [94], which is most associated with the KLOTHO gene in anti-aging processes [95]. A number of publications have examined the relationship of FGF23 and KLOTHO genes in physiological processes and in various diseases [96][97][98][99][100][101][102][103][104]. In this regard, we studied the possible effect of piRNA on the expression of the FGF23 gene.…”

Section: Resultsmentioning

confidence: 99%

piRNAs and miRNAs Can Bind to mRNA of KLOTHO and FGF23 Genes

Ivashchenko,

Akhmetova,

Zhanuzakov

et al. 2023

Preprint

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The problem of increasing life expectancy is solved with the help of many medical and social areas. It has been established that piRNAs and miRNAs can significantly modify the expression of protein-coding genes by suppressing the translation process. The aim of this work was to establish the possibility of binding piRNAs and miRNAs with mRNA of the KLOTHO and FGF23 genes, which promote health and increase life expectancy through participation in key metabolic processes. We used the MirTarget program, which determines the quantitative characteristics of complementary interactions of all piRNAs and miRNAs nucleotides with mRNA of the genes. piR-44682, piR-1940042, piR-3008660, piR-3215034, piR-6885965, piR-7980636 and one miRNA (ID00756.3p-miR) binding to the mRNA of the KLOTHO gene were found in one cluster of binding sites (BSs). piRNA-6890096 interacted with the mRNA of KLOTHO gene in a fully complementary manner using only canonical nucleotides. Among 17494 human genes, target genes interacting with five piRNAs that bind to the mRNA of KLOTHO gene were identified. mRNA of the AFF2, BCL2L11, CPT1A, DAZAP1, NDRG3, SKIDA1, WBP4, ZIC5, ZSWIM6 genes interacted with piR-3215034 and piR-6885965, which formed clusters of BSs located in 5'UTR, CDS and 3'UTR. The piR-576442, piR-1501557, piR-1845735, piR-2069834, and piR-3029987 had BSs in the mRNAs of the FGF23 gene, located only in the 3'UTR. It is proposed to use piRNAs and miRNAs as regulators of the expression of KLOTHO and FGF23 anti-aging genes.

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Section: Resultsmentioning

confidence: 99%

piRNAs and miRNAs Can Bind to mRNA of KLOTHO and FGF23 Genes

Ivashchenko,

Akhmetova,

Zhanuzakov

et al. 2023

Preprint

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Relationship between serum vitamin d levels and the risk of developing metabolic syndrome

López-Chango,

Galárraga Pérez

2023

Salud, Ciencia y Tecnología

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Introducción: El Síndrome Metabólico (MetS) en los últimos años ha incrementado y catalogado como un problema grave de salud mundial, se define como un conjunto de condiciones metabólicas que incrementan el riesgo de enfermedad cardiovascular y diabetes. Mientras la Vitamina D (Vit. D) es una prohormona soluble en grasa, la alteración de los niveles séricos enfocados en la deficiencia de la Vit. D forma parte de nuevas funciones relacionadas con varias enfermedades. Objetivo: El objetivo de este estudio fue indagar la evidencia científica y determinar la relación existente entre los niveles séricos de Vit. D y el riesgo a desarrollar MetS. Métodos: Para la ejecución del artículo de revisión bibliográfica se utilizó un método de investigación documental mediante una búsqueda de información en bases de datos de revistas como SciELO, PubMed, Scopus, Google Académico, Science, y Medline.Resultados: Los artículos indagados proporcionan información relevante sobre, fisiopatología del síndrome metabólico y sus diversos componentes, así como también la fisiopatología, déficit de Vit. D y suplementación de la misma, también se encontró evidencia sobre la relación del déficit de Vit. D y MetS. Conclusiones: Los niveles séricos bajos o déficit de Vitamina D podrían estar relacionados con los diferentes componentes que ayudan al desarrollo del MetS. La suplementación con vitamina D tiene grandes beneficios positivos en personas que padecen MetS.

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Vitamin D and its positive effect on the PTH/vitamin D/calcium-FGF23/klotho/phosphorus axis in kidney transplant recipients

Cited by 2 publications

References 21 publications

piRNAs and miRNAs Can Bind to mRNA of <i>KLOTHO</i> and <i>FGF23</i> Genes

piRNAs and miRNAs Can Bind to mRNA of <i>KLOTHO</i> and <i>FGF23</i> Genes

Relationship between serum vitamin d levels and the risk of developing metabolic syndrome

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