Vitamin D and Low Back Pain - An Mendelian Randomization Study

Abstract

Backgrounds:Low back pain (LBP) is one of the leading cause of health function loss worldwide.There has been ongoing controversy regarding whether vitamin D deficiency can cause lower back pain.This study assessed the impact of 25-OH-D on LBP using Mendelian Randomization. Methods:Using GWAS databases, the exposure variable was set as 25-OH-D, and the outcome as low back pain. IVW, MR-Egger Regression, Simple Median, Weighted Median, and Weighted Mode methods were applied to assess the impact of 25-OH-D on low back pain. Results: IVW analysis revealed no causal relationship between 25-OH-D and low back pain (OR = 1.14, 95% CI: 0.95-1.38, P = 0.165). The MR-Egger intercept test (P >0.05) did not detect pleiotropic effects, indicating robust causal inference using Mendelian Randomization. Conclusion: No causal relationship between serum levels of 25-OH-D and low back pain was identified by MR analysis.