Vitamin D, and Maternal and Child Health

Moon, Rebecca J; Davies, Justin H; Cooper, Cyrus; Harvey, Nicholas C.

doi:10.1007/s00223-019-00560-x

Cited by 30 publications

(26 citation statements)

References 148 publications

(197 reference statements)

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“…This may be due to interindividual variability in vitamin D metabolism and other factors [ 70 , 71 ]. Thus, establishing a personalized dosing regimen has been suggested [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

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Validation and Determination of 25(OH) Vitamin D and 3-Epi25(OH)D3 in Breastmilk and Maternal- and Infant Plasma during Breastfeeding

et al. 2020

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Vitamin D deficiency in pregnant women and their offspring may result in unfavorable health outcomes for both mother and infant. A 25hydroxyvitamin D (25(OH)D) level of at least 75 nmol/L is recommended by the Endocrine Society. Validated, automated sample preparation and liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were used to determine the vitamin D metabolites status in mother-infant pairs. Detection of 3-Epi25(OH)D3 prevented overestimation of 25(OH)D3 and misclassification of vitamin D status. Sixty-three percent of maternal 25(OH)D plasma levels were less than the recommended level of 25(OH)D at 3 months. Additionally, breastmilk levels of 25(OH)D decreased from 60.1 nmol/L to 50.0 nmol/L between six weeks and three months (p < 0.01). Furthermore, there was a positive correlation between mother and infant plasma levels (p < 0.01, r = 0.56) at 3 months. Accordingly, 31% of the infants were categorized as vitamin D deficient (25(OH)D < 50 nmol/L) compared to 25% if 3-Epi25(OH)D3 was not distinguished from 25(OH)D3. This study highlights the importance of accurate quantification of 25(OH)D. Monitoring vitamin D metabolites in infant, maternal plasma, and breastmilk may be needed to ensure adequate levels in both mother and infant in the first 6 months of infant life.

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“…This may be due to interindividual variability in vitamin D metabolism and other factors [ 70 , 71 ]. Thus, establishing a personalized dosing regimen has been suggested [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, Norwegian maternal vitamin D < 30 nmol/L has been associated with lower offspring peak bone mass [ 36 ]. Personalized vitamin D supplementation during pregnancy and lactation has been suggested [ 37 ]. Monitoring vitamin D deficiency in Norwegian mother-infant pairs before and after childbirth is therefore of importance.…”

Section: Introductionmentioning

confidence: 99%

Validation and Determination of 25(OH) Vitamin D and 3-Epi25(OH)D3 in Breastmilk and Maternal- and Infant Plasma during Breastfeeding

et al. 2020

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“…The variance between countries was also considered. Further, sunlight exposure as the most important source for vitamin D synthesis was also taken into consideration [50], calculated by mean daylight duration for each examination month in each location based on astronomical tables [26].…”

Section: Confounding Variablesmentioning

confidence: 99%

Cross-sectional and longitudinal associations between physical activity, sedentary behaviour and bone stiffness index across weight status in European children and adolescents

Cheng

Pohlabeln

Ahrens

et al. 2020

Int J Behav Nutr Phys Act

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Background: The associations between physical activity (PA), sedentary behaviour (SB) and bone health may be differentially affected by weight status during growth. This study aims to assess the cross-sectional and longitudinal associations between PA, SB and bone stiffness index (SI) in European children and adolescents, taking the weight status into consideration. Methods: Calcaneus SI was first measured by quantitative ultrasound among children aged 2-9 years old in 2007/ 08. It was measured again after 2 years in the IDEFICS study and after 6 years in the I. Family study. A sample of 2008 participants with time spent at sports clubs, watching TV and playing computer/games self-reported by questionnaire, and a subsample of 1037 participants with SB, light PA (LPA) and moderate-to-vigorous PA (MVPA) objectively measured using Actigraph accelerometers were included in the analyses. Weight status was defined as thin/normal and overweight/obese according to the extended International Obesity Task Force criteria. Linear mixed-effects models were used to estimate the cross-sectional and longitudinal associations between PA, SB and SI percentiles, stratified by weight status.

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“…The role of vitamin D in health and disease prevention involves effects on hormonal pathways, immune system development and infection, as well as cell proliferation and differentiation [ 3 , 4 ]. Moreover, vitamin D is important for the growth and development of the skeletal system via calcium metabolism [ 3 , 5 ]. Low maternal 25(OH)D levels have also been associated with an increased risk of poor maternal and neonatal outcomes, including gestational diabetes, preeclampsia, preterm birth, and low-birth-weight infants [ 6 , 7 , 8 ], with vitamin D implicated in placental and immune function, neurodevelopment and lung development [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Serum 25 Hydroxyvitamin D Levels During Pregnancy in Women with Asthma: Associations with Maternal Characteristics and Adverse Maternal and Neonatal Outcomes

et al. 2020

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Low 25-hydroxyvitamin D (25(OH)D) levels are common in pregnancy and associated with adverse maternal/neonatal outcomes. In pregnant women with asthma, this study examined the association of lifestyle- and asthma-related factors on 25(OH)D levels and maternal/neonatal outcomes by vitamin D status. Serum 25(OH)D was measured at 16 and 35 weeks gestation in women with asthma (n = 103). Body mass index (BMI), gestational weight gain (GWG), smoking status, inhaled corticosteroid (ICS) use, asthma control, airway inflammation, and exacerbations, and maternal/neonatal outcomes were collected. Baseline and change (Δ) in 25(OH)D were modelled separately using backward stepwise regression, adjusted for season and ethnicity. Maternal/neonatal outcomes were compared between low (25(OH)D < 75 nmol/L at both time points) and high (≥75 nmol/L at one or both time points) vitamin D status. Fifty-six percent of women had low vitamin D status. Obesity was significantly associated with lower baseline 25(OH)D (Adj-R2 = 0.126, p = 0.008); ICS and airway inflammation were not. Excess GWG and season of baseline sample collection were significantly associated with Δ25(OH)D (Adj-R2 = 0.405, p < 0.0001); asthma-related variables were excluded (p > 0.2). Preeclampsia was more common in the low (8.6%) vs. high (0%) vitamin D group (p < 0.05). Obesity and excess GWG may be associated with gestational 25(OH)D levels, highlighting the importance of antenatal weight management.

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Vitamin D, and Maternal and Child Health

Cited by 30 publications

References 148 publications

Validation and Determination of 25(OH) Vitamin D and 3-Epi25(OH)D3 in Breastmilk and Maternal- and Infant Plasma during Breastfeeding

Validation and Determination of 25(OH) Vitamin D and 3-Epi25(OH)D3 in Breastmilk and Maternal- and Infant Plasma during Breastfeeding

Cross-sectional and longitudinal associations between physical activity, sedentary behaviour and bone stiffness index across weight status in European children and adolescents

Serum 25 Hydroxyvitamin D Levels During Pregnancy in Women with Asthma: Associations with Maternal Characteristics and Adverse Maternal and Neonatal Outcomes

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