Vitamin D and MicroRNAs in Bone

Lisse, Thomas S.; Adams, John S.; Hewison, Martin

doi:10.1615/critreveukaryotgeneexpr.2013007147

Cited by 54 publications

(40 citation statements)

References 140 publications

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“…Five miRNAs were found to be differentially expressed in primary human osteoblast after 6 h of treatment with 1,25D3 (Lisse et al, 2013a,b). Interestingly, miR-637 and miR-1228 are two miRNAs located intergenic in DAPK3 and LRP1, respectively.…”

Section: Vitamin D and Gene Transcription In The Context Of Osteoblasmentioning

confidence: 99%

“…miR-637 stimulated the degradation of COL4A mRNA levels that is expressed in the basement membrane and is downregulated during early differentiation of mouse MC3T3-E1 osteoblasts (Hong et al, 2010). It is becoming evident that miRNAs play an important role in osteoblast differentiation and bone formation (Lian et al, 2012) and in the near future more data on their role in 1,25D3 action in osteoblasts will come forward (Lisse et al, 2013a). …”

Section: Vitamin D and Gene Transcription In The Context Of Osteoblasmentioning

confidence: 99%

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Vitamin D and gene networks in human osteoblasts

Peppel¹,

Leeuwen²

2014

Front. Physiol.

110

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Bone formation is indirectly influenced by 1,25-dihydroxyvitamin D3 (1,25D3) through the stimulation of calcium uptake in the intestine and re-absorption in the kidneys. Direct effects on osteoblasts and bone formation have also been established. The vitamin D receptor (VDR) is expressed in osteoblasts and 1,25D3 modifies gene expression of various osteoblast differentiation and mineralization-related genes, such as alkaline phosphatase (ALPL), osteocalcin (BGLAP), and osteopontin (SPP1). 1,25D3 is known to stimulate mineralization of human osteoblasts in vitro, and recently it was shown that 1,25D3 induces mineralization via effects in the period preceding mineralization during the pre-mineralization period. For a full understanding of the action of 1,25D3 in osteoblasts it is important to get an integrated network view of the 1,25D3-regulated genes during osteoblast differentiation and mineralization. The current data will be presented and discussed alluding to future studies to fully delineate the 1,25D3 action in osteoblast. Describing and understanding the vitamin D regulatory networks and identifying the dominant players in these networks may help develop novel (personalized) vitamin D-based treatments. The following topics will be discussed in this overview: (1) Bone metabolism and osteoblasts, (2) Vitamin D, bone metabolism and osteoblast function, (3) Vitamin D induced transcriptional networks in the context of osteoblast differentiation and bone formation.

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Section: Vitamin D and Gene Transcription In The Context Of Osteoblasmentioning

confidence: 99%

Section: Vitamin D and Gene Transcription In The Context Of Osteoblasmentioning

confidence: 99%

Vitamin D and gene networks in human osteoblasts

Peppel¹,

Leeuwen²

2014

Front. Physiol.

110

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“…De même, la vitamine D agit sur la régulation mais également le recrutement d'histone acétylases (HAT) et d'histones désacétylases (HDAC), permettant ainsi de jouer sur le niveau d'acétylation des histones (Karlic, et al, 2013). Enfin la vitamine D via le VDR est également capable de réguler l'expression de miRNAs, soit directement soit indirectement en modulant l'activité de facteurs de transcription (Lisse, et al, 2013).…”

Section: Les Mécanismes D'action De La Vitamine Dunclassified

Vitamine D : sources, métabolisme et mécanismes d’action

Landrier

2014

Cahiers de Nutrition et de Diététique

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Résumé -Longtemps cantonné à son rôle dans le métabolisme phosphocalcique, la vitamine D apparaît aujourd'hui comme une vitamine aux multiples potentialités, puisqu'étant impliquée dans de nombreux processus physiologiques. De part se double origine alimentaire et endogène, la vitamine D constitue une vitamine à part, dont les apports et les besoins restent délicats à définir et font actuellement débat. En revanche, le métabolisme de cette vitamine D est mieux connu. On sait de longue date que son métabolisme implique notamment une hydroxylation hépatique conduisant à la formation de la 25(OH)D ainsi qu'une hydroxylation rénale aboutissant à la formation du 1,25(OH) 2 D, le métabolite actif de la vitamine D. Ce métabolite est responsable des différents effets génomiques et non-génomiques de la vitamine D, dont les mécanismes d'action impliquent notamment un récepteur nucléaire spécifique, le Vitamin D Receptor (VDR) et diverses voies de signalisation contrôlées par un récepteur membranaire, la protein disulfide isomerase family A member 3 (Pdia3). Mots clés :Vitamine D / métabolisme / VDR / Pdia3 / nutrition Abstract -Vitamin D: sources, metabolism and mechanisms of action. Confined for a long time to its role in calcium and phosphate metabolism, vitamin D appears today as a vitamin with a large potential, through its involved in many physiological processes. Due to its double origin (from food and endogenous synthesis), vitamin D is a vitamin apart, with sources and requirements difficult to define that are currently discussing. However, the metabolism of the vitamin D begins to be known more precisely. This metabolism involves a first hepatic hydroxylation leading to the formation of 25(OH)D and second hydroxylation in kidney resulting in the formation of 1,25(OH) 2 D, the active metabolite of vitamin D. This metabolite is responsible for the various genomic and non-genomic effects of vitamin D, whose mechanism of action involves a specific nuclear receptor, the Vitamin D Receptor (VDR), and various signaling pathways controlled by a membrane receptor, the protein disulfide isomerase family A member 3 (Pdia3).Initialement identifiée pour son action antirachitique puis longuement cantonnée au métabolisme phosphocalcique, la vitamine D fait l'objet de toutes les attentions depuis quelques années, ce qui a permis des avancées majeures dans la connaissance de son métabolisme, de ses mécanismes d'action et par conséquent de ses nombreux effets métaboliques. Le niveau sanguin de 25-hydroxyvitamine D (25(OH)D) est le meilleur marqueur du statut en vitamine D. Lorsque le taux sérique de 25(OH)D est supérieur à 30 ng/ml (75 nmol/L), le statut vitaminique D peut être qualifié d'optimal. À l'inverse, le terme de statut vitaminique D suboptimal est souvent utilisé lorsqu'il est inférieur à 30 ng/ml. Cette valeur de 30 ng/ml est en effet considérée comme le seuil en deçà duquel apparaît une hyperparathyroïdie secondaire à l'hypovitaminose D,

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“…In addition, recent studies have also implicated microRNAs (miRNAs) in mediating the fine-tuning of vitamin D-mediated responses [21–23]. The liganded VDR complex can either suppress or induce miRNAs by either direct transcriptional regulation of autonomous miRNA genesor indirect regulation of miRNAs via host gene promoter sequences [24]. Conversely, miRNAs may act to regulate 1,25(OH) 2 D synthesis, catabolism, or signaling to form dynamic feedback mechanisms (comprehensive review, see [24]).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and alternative splicing of RNA

Zhou

Chun

Lisse

et al. 2015

The Journal of Steroid Biochemistry and Molecular Biology

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The active form of vitamin D (1α,25-dihydroxyvitamin D, 1,25(OH)2D) exerts its genomic effects via binding to a nuclear high-affinity vitamin D receptor (VDR). Recent deep sequencing analysis of VDR binding locations across the complete genome has significantly expanded our understanding of the actions of vitamin D and VDR on gene transcription. However, these studies have also promoted appreciation of the extra-transcriptional impact of vitamin D on gene expression. It is now clear that vitamin D interacts with the epigenome via effects on DNA methylation, histone acetylation, and microRNA generation to maintain normal biological functions. There is also increasing evidence that vitamin D can influence pre-mRNA constitutive splicing and alternative splicing, although the mechanism for this remains unclear. Pre-mRNA splicing has long been thought to be a post-transcription RNA processing event, but current data indicate that this occurs co-transcriptionally. Several steroid hormones have been recognized to coordinately control gene transcription and pre-mRNA splicing through the recruitment of nuclear receptor co-regulators that can both control gene transcription and splicing. The current review will discuss this concept with specific reference to vitamin D, and the potential role of heterogeneous nuclear ribonucleoprotein C (hnRNPC), a nuclear factor with an established function in RNA splicing. hnRNPC, has been shown to be involved in the VDR transcriptional complex as a vitamin D-response element-binding protein (VDRE-BP), and may act as a coupling factor linking VDR-directed gene transcription with RNA splicing. In this way hnRNPC may provide an additional mechanism for the fine-tuning of vitamin D-regulated target gene expression.

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Vitamin D and MicroRNAs in Bone

Cited by 54 publications

References 140 publications

Vitamin D and gene networks in human osteoblasts

Vitamin D and gene networks in human osteoblasts

Vitamine D : sources, métabolisme et mécanismes d’action

Vitamin D and alternative splicing of RNA

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