Vitamin D and Non-coding RNAs: New Insights into the Regulation of Breast Cancer

Shahrzad, Mohammad Karim; Gharehgozlou, Reyhaneh; Fadaei, Sara; Hajian, Parastoo

doi:10.2174/1566524020666200712182137

Cited by 10 publications

(11 citation statements)

References 163 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence of the specific functional relationships between vitamin D/VDR and lncRNAs is summarized in Table 2 . Notably, the protective role of vitamin D against breast cancer through lncRNA-mediated pathways has been elucidated in detail [ 19 , 20 ]. Here we provided an update of current research and extracted the main regulatory axes with vitamin D/VDR and lncRNAs as reported there (Table 2 ).…”

Section: Functional Link Between Fat-soluble Vitamins (A D E and K) A...mentioning

confidence: 99%

“…We then tabulated and discussed the available research, highlighting any links between vitamins and lncRNAs. To our knowledge, this is the first review that has comprehensively profiled the co-contribution of lncRNAs and multiple vitamins to common pathways, beyond the vitamin D/VDR pathway that has been the focus of prior published studies [ 19 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Yazarlou,

Alizadeh,

Lipovich

et al. 2024

Genes Nutr

View full text Add to dashboard Cite

A major revelation of genome-scale biological studies in the post-genomic era has been that two-thirds of human genes do not encode proteins. The majority of non-coding RNA transcripts in humans are long non-coding RNA (lncRNA) molecules, non-protein-coding regulatory transcripts with sizes greater than 500 nucleotides. LncRNAs are involved in nearly every aspect of cellular physiology, playing fundamental regulatory roles both in normal cells and in disease. As result, they are functionally linked to multiple human diseases, from cancer to autoimmune, inflammatory, and neurological disorders. Numerous human conditions and diseases stem from gene-environment interactions; in this regard, a wealth of reports demonstrate that the intake of specific and essential nutrients, including vitamins, shapes our transcriptome, with corresponding impacts on health. Vitamins command a vast array of biological activities, acting as coenzymes, antioxidants, hormones, and regulating cellular proliferation and coagulation. Emerging evidence suggests that vitamins and lncRNAs are interconnected through several regulatory axes. This type of interaction is expected, since lncRNA has been implicated in sensing the environment in eukaryotes, conceptually similar to riboswitches and other RNAs that act as molecular sensors in prokaryotes. In this review, we summarize the peer-reviewed literature to date that has reported specific functional linkages between vitamins and lncRNAs, with an emphasis on mammalian models and humans, while providing a brief overview of the source, metabolism, and function of the vitamins most frequently investigated within the context of lncRNA molecular mechanisms, and discussing the published research findings that document specific connections between vitamins and lncRNAs.

show abstract

Section: Functional Link Between Fat-soluble Vitamins (A D E and K) A...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Yazarlou,

Alizadeh,

Lipovich

et al. 2024

Genes Nutr

View full text Add to dashboard Cite

show abstract

“…Furthermore, epigenetics can also be related to factors such as diet [ 123 ]. Other epigenetic modifications may also be related to vitamin D levels and the risk of developing BC, such as histone methylation [ 50 , 124 ] and the regulation and expression of miRNAs [ 125 , 126 , 127 ].…”

Section: Resultsmentioning

confidence: 99%

The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review

Torres,

Cameselle,

Otero

et al. 2024

Nutrients

View full text Add to dashboard Cite

Vitamin D deficiency is currently a significant public health issue closely linked to numerous diseases, such as breast cancer. This study aims to determine the estimated optimal serum levels of vitamin D to have a protective effect against breast cancer, in addition to exploring the biological mechanisms and risk factors involved. A literature search of articles published in the last 5 years was conducted, and simple statistical analyses using mean and standard deviation were performed to calculate the average concentration of vitamin D from different available studies. It has been observed that serum levels of vitamin D ≥ 40.26 ng/mL ± 14.19 ng/mL could exert a protective effect against breast cancer. Additionally, various biological mechanisms, such as those related to the immune system, and risk factors like diet implicated in this relationship were elucidated. Consequently, it can be concluded that proper serum levels of vitamin D may have a protective effect against breast cancer, and dietary supplementation may be an appropriate procedure to achieve these optimal vitamin D concentrations.

show abstract

“…Furthermore, it seems that the genes coding transcription factors (TFs) are activated by 1,25(OH) 2 D 3 , which in turn regulates the expression of additional sets of genes [ 36 ], which could be described as secondary genomic response. Recently, regulatory effects of 1,25(OH) 2 D 3 on the expression of microRNAs and long noncoding RNAs have been uncovered as a potential anticancer mechanism [ 37 , 38 ].…”

Section: Vitamin D—overviewmentioning

confidence: 99%

Nongenomic Activities of Vitamin D

Żmijewski

2022

Nutrients

View full text Add to dashboard Cite

Vitamin D shows a variety of pleiotropic activities which cannot be fully explained by the stimulation of classic pathway- and vitamin D receptor (VDR)-dependent transcriptional modulation. Thus, existence of rapid and nongenomic responses to vitamin D was suggested. An active form of vitamin D (calcitriol, 1,25(OH)2D3) is an essential regulator of calcium–phosphate homeostasis, and this process is tightly regulated by VDR genomic activity. However, it seems that early in evolution, the production of secosteroids (vitamin-D-like steroids) and their subsequent photodegradation served as a protective mechanism against ultraviolet radiation and oxidative stress. Consequently, direct cell-protective activities of vitamin D were proven. Furthermore, calcitriol triggers rapid calcium influx through epithelia and its uptake by a variety of cells. Subsequently, protein disulfide-isomerase A3 (PDIA3) was described as a membrane vitamin D receptor responsible for rapid nongenomic responses. Vitamin D was also found to stimulate a release of secondary massagers and modulate several intracellular processes—including cell cycle, proliferation, or immune responses—through wingless (WNT), sonic hedgehog (SSH), STAT1-3, or NF-kappaB pathways. Megalin and its coreceptor, cubilin, facilitate the import of vitamin D complex with vitamin-D-binding protein (DBP), and its involvement in rapid membrane responses was suggested. Vitamin D also directly and indirectly influences mitochondrial function, including fusion–fission, energy production, mitochondrial membrane potential, activity of ion channels, and apoptosis. Although mechanisms of the nongenomic responses to vitamin D are still not fully understood, in this review, their impact on physiology, pathology, and potential clinical applications will be discussed.

show abstract

Vitamin D and Non-coding RNAs: New Insights into the Regulation of Breast Cancer

Cited by 10 publications

References 163 publications

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review

Nongenomic Activities of Vitamin D

Contact Info

Product

Resources

About