Vitamin D and Obesity: Current Evidence and Controversies

Karampela, Ιrene; Sakelliou, Alexandra; Vallianou, Natalia; Christodoulatos, Gerasimos Socrates; Magkos, Faidon; Dalamaga, Maria

doi:10.1007/s13679-021-00433-1

Cited by 138 publications

(97 citation statements)

References 119 publications

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“…This association could potentially be further dampened by multiple confounding factors such as dietary choices, race, ethnicity, lack of sun exposure, and sedentary lifestyles. It is our belief that the mechanisms linking low 25(OH)-vitamin D levels to increased obesity will be better understood in the future thanks to ongoing molecular research on the CYP2R1 gene, VDR, adipogenesis, and adipolysis [70].…”

Section: Deficit In Obesity and Impact Of Supplementation On Weight Lossmentioning

confidence: 99%

Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto’s Disease and Grave’s Disease), Diabetes Mellitus and Obesity

et al. 2022

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Background and Objectives: Vitamin D deficiency is involved in numerous pathologies, including endocrine pathology. The purpose of this review consists of presenting the role of vitamin D in the pathophysiology of certain endocrine disorders, autoimmune thyroid disorders (Hashimoto’s disease and Grave’s disease), diabetes mellitus, and obesity, and whether its supplementation can influence the outcome of these diseases. Materials and Methods: Review articles and original articles from the literature were consulted that corresponded with the thematic. Results: Vitamin D deficiency is frequently encountered in endocrine disorders and supplementation restores the normal values. In Hashimoto’s disease, vitamin D deficiency appears to be correlated with a higher titer of anti-TPO antibodies and with thyroid volume, and supplementation was associated with reduction of antibodies in some studies. In other studies, supplementation appeared to reduce TSH levels. In Grave’s disease, there was a significant correlation regarding vitamin D levels and thyroid volume respective to the degree of exophthalmos. In diabetes mellitus type 2 patients, supplementation led to some improvement of the HOMA-IR index and HbA1c, whereas obesity data from literature do not report significant beneficial findings. Conclusions: Vitamin D deficiency is highly prevalent in endocrine disorders and its supplementation appears to have numerous beneficial effects.

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Section: Deficit In Obesity and Impact Of Supplementation On Weight Lossmentioning

confidence: 99%

Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto’s Disease and Grave’s Disease), Diabetes Mellitus and Obesity

et al. 2022

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“…(89) The protective effect of vitamin D supplementation in the VITAL study appeared to be restricted to those participants with normal body mass index (BMI), consistent with the known adverse effects of obesity on vitamin D action. (90) Despite the large number of participants recruited to this trial, there were insufficient numbers of breast cancer cases to specifically test the impact of vitamin D 3 supplementation on breast cancer incidence or mortality. A limitation of the VITAL trial was that serum 25D was not measured, therefore subjects could not be stratified by vitamin D status at baseline or after supplementation.…”

Section: Impact Of Vitamin D Signaling In Breast Cancer Prevention and Treatment: Animal Modelsmentioning

confidence: 99%

Vitamin D and Breast Cancer: Mechanistic Update

Welsh

2021

JBMR Plus

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The presence of the vitamin D receptor (VDR) in mammary gland and breast cancer has long been recognized, and multiple preclinical studies have demonstrated that its ligand, 1,25-dihydroxyvitamin D (1,25D), modulates normal mammary gland development and inhibits growth of breast tumors in animal models. Vitamin D deficiency is common in breast cancer patients, and some evidence suggests that low vitamin D status enhances the risk for disease development or progression. Although many 1,25Dresponsive targets in normal mammary cells and in breast cancers have been identified, validation of specific targets that regulate cell cycle, apoptosis, autophagy, and differentiation, particularly in vivo, has been challenging. Model systems of carcinogenesis have provided evidence that both VDR expression and 1,25D actions change with transformation, but clinical data regarding vitamin D responsiveness of established tumors is limited and inconclusive. Because breast cancer is heterogeneous, the relevant VDR targets and potential sensitivity to vitamin D repletion or supplementation will likely differ between patient populations. Detailed analysis of VDR actions in specific molecular subtypes of the disease will be necessary to clarify the conflicting data. Genomic, proteomic, and metabolomic analyses of in vitro and in vivo model systems are also warranted to comprehensively understand the network of vitamin D-regulated pathways in the context of breast cancer heterogeneity. This review provides an update on recent studies spanning the spectrum of mechanistic (cell/molecular), preclinical (animal models), and translational work on the role of vitamin D in breast cancer.

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“…However, the majority of the current nutritional epidemiological studies only evaluated the impact of individual vitamin intake on childhood obesity (11)(12)(13)(14). Those studies only focused on the association between vitamins in isolation and childhood obesity, rather than considering all vitamins intakes, which might have additive, synergistic, antagonistic, or enhancing effects when they took together.…”

Section: Introductionmentioning

confidence: 99%

Associations Between Different Dietary Vitamins and the Risk of Obesity in Children and Adolescents: A Machine Learning Approach

Tang

Zhan²,

Wei³

et al. 2022

Front. Endocrinol.

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BackgroundsSimultaneous dietary intake of vitamins is considered as a common and real scenario in daily life. However, limited prospective studies have evaluated the association between multivitamins intake and obesity in children and adolescents.ObjectivesThis study aimed to evaluate the relationship between the intake of different dietary vitamins and the risk of obesity in children (6-11 years) and adolescents (12-19 years).MethodsWe conducted a cross-sectional study based on data from U.S. National Health and Nutrition Examination Survey, 2013-2016. A total of 3634 children and adolescents were included who had available data on dietary vitamins, obesity and covariates. We analyzed the dietary intake levels of nine vitamins, including vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K. Multivariate logistic regression was used to model the associations between vitamins and obesity. Bayesian kernel machine regression (BKMR) was employed to explore the joint and independent effects of vitamins on obesity among children and adolescents.ResultsIn the multivariate logistic regression model, five vitamins (vitamin A, vitamin B1, vitamin B2, vitamin B12, and vitamin D) were negatively associated with obesity in children and adolescents. BKMR analysis showed that when the concentration of the nine vitamins was at or above the 55th percentile compared with the median value, the combined intake of these vitamins could significantly reduce the risk of obesity in children and adolescents. Potential interactions between vitamin B2 and vitamin B12 in increasing the risk of obesity in children and adolescents were observed.ConclusionsWe determine the combined effects of multivitamins on obesity in children and adolescents, and observe a significant interaction between vitamin B2 and vitamin B12. Further cohort studies are needed to clarify the health effects of multivitamins intake in a larger population.

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Vitamin D and Obesity: Current Evidence and Controversies

Cited by 138 publications

References 119 publications

Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto’s Disease and Grave’s Disease), Diabetes Mellitus and Obesity

Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto’s Disease and Grave’s Disease), Diabetes Mellitus and Obesity

Vitamin D and Breast Cancer: Mechanistic Update

Associations Between Different Dietary Vitamins and the Risk of Obesity in Children and Adolescents: A Machine Learning Approach

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