Vitamin D binding protein and vitamin D in human allergen-induced endobronchial inflammation

Bratke, Kai; Wendt, Anna; Garbe, Katharina; Kuepper, Michael; Julius, Peter; Lommatzsch, Marek; Virchow, J. Christian

doi:10.1111/cei.12346

Cited by 24 publications

(19 citation statements)

References 29 publications

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“…These findings suggest that these factors may play a role in the late-phase response in asthma. 55 In a Korean study, it was found that low serum 25(OH)D levels were positively associated with total IgE levels which varied based on gender and sensitization to Dermatophagoides farina . Overall, patients with a history of asthma or atopic dermatitis had significantly lower serum 25(OH)D levels than patients who did not suffer from these conditions.…”

Section: Adultsmentioning

confidence: 99%

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall

Agrawal

2017

Clinical Therapeutics

101

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Vitamin D is a potent immunomodulator capable of dampening inflammatory signals in several cell types involved in the asthmatic response. Its deficiency has been associated with increased inflammation, exacerbations and overall worse outcomes in patients with asthma. Given the increase in the prevalence of asthma over the last few decades, there has been enormous interest in the use of vitamin D supplementation as a potential therapeutic option. Several studies have found that low serum levels of vitamin D (< 20 ng/ml) are associated with increased exacerbations, increased airway inflammation, decreased lung function and poor prognosis in asthmatic patients. Results from the in vitro and in vivo studies in animals and human have suggested that supplementation with vitamin D can ameliorate several hallmark features of asthma. However, the findings obtained from clinical trials are controversial and do not unequivocally support the beneficial role of vitamin D in asthma. Largely, interventional studies in children, pregnant women and adults have primarily found little-to-no effect of vitamin D supplementation on improved asthma symptoms, onset or progression of the disease. This could be related to the severity of the disease process and other confounding factors. Despite the conflicting data obtained from clinical trials, vitamin D deficiency does influence the inflammatory response in the airways. Further studies are needed to determine the exact mechanisms by which vitamin D supplementation may induce anti-inflammatory effects. Here, we critically reviewed the most recent findings from in vitro studies, animal models, and clinical trials regarding the role of vitamin D in bronchial asthma.

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Section: Adultsmentioning

confidence: 99%

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall

Agrawal

2017

Clinical Therapeutics

101

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“…[24][25][26][27][28][29][30] The iCOGs array directly genotyped rs12794714 and rs2282679; rs7944926 was the best imputed DHCR7 SNPs (imputation quality score of 0.92) described by previous study. 31 We were unable to include rs6013897 in …”

Section: Snp Selection Criteriamentioning

confidence: 99%

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study

Ong¹,

Cuéllar-Partida²,

Lu³

et al. 2016

Int. J. Epidemiol.

114

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Background: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer. Methods: We employed SNPs with well-established associations with 25(OH)D concentration as instrumental variables for MR: rs7944926 (DHCR7), rs12794714 (CYP2R1) and rs2282679 (GC). We included 31 719 women of European ancestry (10 065 cases, 21 654 controls) from the Ovarian Cancer Association Consortium, who were genotyped using customized Illumina Infinium iSelect (iCOGS) arrays. A two-sample (summary data) MR approach was used and analyses were performed separately for all ovarian cancer (10 065 cases) and for high-grade serous ovarian cancer (4121 cases). Results: The odds ratio for epithelial ovarian cancer risk (10 065 cases) estimated by combining the individual SNP associations using inverse variance weighting was 1.27 (95% confidence interval: 1.06 to 1.51) per 20 nmol/L decrease in 25(OH)D concentration. The estimated odds ratio for high-grade serous epithelial ovarian cancer (4121 cases) was 1.54 (1.19, 2.01). Conclusions: Genetically lowered 25-hydroxyvitamin D concentrations were associated with higher ovarian cancer susceptibility in Europeans. These findings suggest that increasing plasma vitamin D levels may reduce risk of ovarian cancer.

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“…18 A recent study showed increased levels of vitamin D-binding protein and 25-hydroxyvitamin D in bronchoalveolar lavage fluid after allergen challenge, suggesting a role for these factors in allergic late-phase reactions. 19 A low serum vitamin D level may represent a marker of Western life style. Modern life is associated with less time spent outdoors; altered nutrition; increased obesity; exposure to cigarette smoking, ultrafine particles, and ozone; and inadequate physical activity.…”

Section: Introductionmentioning

confidence: 99%