Vitamin D-binding protein gene polymorphisms and chronic obstructive pulmonary disease susceptibility: A meta-analysis

Xie, Xinming; Zhang, Yonghong; Rui, Ke; Wang, Guizuo; Wang, Shengyu; Hussain, Tafseel; Li, Shaojun; Li, Manxiang

doi:10.3892/br.2014.392

Cited by 11 publications

(7 citation statements)

References 34 publications

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“…Previous studies have investigated the association between GC polymorphisms and susceptibility to COPD. 13 , 16 Thus, a meta-analysis study has revealed that in Asian population, genotype 1F-1F is a risk factor for developing COPD, while genotype 2-2 indicates protection against the disease. In Korean population, genotype 1S-1S has been identified as a risk factor for COPD.…”

Section: Discussionmentioning

confidence: 99%

“… 17 However, no significant association has been found between GC polymorphisms and COPD susceptibility in Caucasian population. 16 …”

Section: Discussionmentioning

confidence: 99%

“…Although vitamin D status and GC polymorphisms are closely related, their association with clinical outcomes in COPD has not been yet investigated, since most of the previous studies on COPD have examined the individual contribution of each factor. 6 , 16 , 17 Therefore, the purpose of this study was to determine the relationship between common GC polymorphisms and vitamin D3 level in Korean patients with COPD. We assumed that certain GC variants would be associated with vitamin D3 level, indicating susceptibility to vitamin D deficiency.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD

Park

Kim

Kang

et al. 2016

COPD

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BackgroundIn chronic obstructive pulmonary disease (COPD), the blood vitamin D3 level is generally low, and genetic polymorphisms of vitamin D-binding protein encoded by the GC gene are associated with COPD development. In this study, we examined the relationship between GC polymorphisms and plasma vitamin D3 level in Korean patients with COPD.MethodsThe study included 175 COPD patients from the Korean Obstructive Lung Disease Cohort. Multivariate analysis was conducted with adjustment for age, body mass index (BMI), lung function, smoking status, smoking amount, and seasonal variation in blood vitamin D level. Vitamin D deficiency was defined as a plasma 25-hydroxyvitamin D3 level lower than 20 ng/mL.ResultsThe mean plasma vitamin D3 level was 17.5 ng/mL. The GC1F variant (44.3%) and genotype 1F-2 (27.4%) were the most common. The plasma vitamin D3 level was lower in patients with the GC2 variant (estimated =−3.73 ng/mL) and higher in those with genotype 1F-1S (estimated =4.08 ng/mL). The GC2 variant was a significant risk factor for vitamin D deficiency (odds ratio =2.41). Among COPD clinical parameters, vitamin D deficiency was associated with a lower ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) regardless of GC polymorphisms. FEV1/FVC was higher in patients with genotype 1F-1F (estimated =3.61%) and lower in those with genotype 1F-2 (estimated =−3.31%). The 6-minute walking distance was shorter for patients with the GC1F variant (estimated =−38.91 m) and longer for those with the GC2 variant (estimated =26.98 m). The emphysema index was higher for patients with the GC1S variant (estimated =6.56%) and genotype 1F-1S (estimated =9.86%), regardless of the vitamin D level.ConclusionThe GC2 variant is a risk factor for vitamin D deficiency, and genotype 1F-1S is a protective factor against vitamin D deficiency. GC polymorphisms and vitamin D deficiency correlate with clinical outcomes for Korean patients with COPD.

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Section: Discussionmentioning

confidence: 99%

“… 17 However, no significant association has been found between GC polymorphisms and COPD susceptibility in Caucasian population. 16 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD

Park

Kim

Kang

et al. 2016

COPD

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“…The critical extra-skeletal effects of vitamin D has been widely recognized in recent years, 6 particularly its roles in chronic diseases such as the chronic lung disease COPD. Several studies have reported that VDBP genotype was associated with high COPD susceptibility, 15 , 42 , 43 suggesting that the serum level of 25(OH)D was linked with COPD susceptibility. However, VDBP level had no effects on serum 25(OH)D concentration.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency is associated with the severity of COPD: a systematic review and meta-analysis

Zhu

Xiao

Zheng

2015

COPD

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PurposeTo explore the association between host serum 25-hydroxyvitamin D (25(OH)D) and the susceptibility and severity of COPD.MethodsPrevious studies on the association between host 25(OH)D and the susceptibility and severity of COPD were collected on the basis of a systematic literature search of PubMed and Web of Science up to June 2015. Continuous variable data were presented as standard mean difference (SMD) or weighted mean difference with 95% confidence interval (CI). The dichotomous variable data were analyzed as relative ratio (RR) or odds ratio with 95% CI for cohort and case-control studies. A systematic review was conducted to understand the curative and side effects of vitamin D intake.ResultsA total of 18 studies including eight cohort, five case-control, and five randomized studies met the inclusion criteria. The serum level of 25(OH)D in COPD patients was comparable with controls with a pooled SMD of 0.191 (95% CI: −0.126 to 0.508, P=0.237) based on pooled analyses of cohort studies. However, the serum level of 25(OH)D in COPD patients was lower with a pooled SMD of 0.961 (95% CI: 0.476–1.446, P<0.001) compared with controls based on pooled analyses of case-control studies. The deficiency rates of 25(OH)D were comparable between controls and COPD patients with a pooled RR of 0.955 (95% CI: 0.754–1.211, P=0.705) based on analyses of cohort studies, and the same results were observed based on pooled analyses of case-control studies. Interestingly, the deficiency rate of 25(OH)D was significantly lower in moderate or severe COPD patients with a pooled RR of 0.723 (95% CI: 0.632–0.828, P<0.001) compared with that in mild COPD patients. The same results were obtained from the pooled analysis between moderate and severe COPD patients. The four randomized studies showed that vitamin D intake provided benefit for COPD patients.ConclusionLow serum levels of 25(OH)D were not associated with COPD susceptibility, but the high deficiency rate of 25(OH)D was associated with COPD severity. Vitamin D supplementation may prevent COPD exacerbation.

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“…This could result in reduced pulmonary inflammation in GC2 carriers and may in part explain results from recent meta-analyses showing that the GC2 variant protects against COPD in Asian populations. 21,32 Thus, a comprehensive investigation of these SNPs' stratification in sputum and plasma VDBP expression in a longitudinal COPD study is warranted.…”

Section: Introductionmentioning

confidence: 99%

<p>Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD</p>

Gao

Törölä

et al. 2020

COPD

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The vitamin D binding protein (VDBP, also known as GC-globulin) and vitamin D deficiency have been associated with chronic obstructive pulmonary disease (COPD). rs7041 and rs4588 are two single nucleotide polymorphisms of the VDBP gene, including three common allelic variants (GC1S, GC1F and GC2). Previous studies primarily assessed the serum levels of vitamin D and VDBP in COPD. However, less is known regarding the impact of the local release of VDBP on COPD lung function. Thus, we examined the association of sputum and plasma VDBP with lung function at baseline and at four years, and examined potential genetic polymorphism interactions. Methods: The baseline levels of sputum VDBP, plasma VDBP and plasma 25-OH vitamin D, as well as the GC rs4588 and rs7041 genotypes, were assessed in a 4-year Finnish follow-up cohort (n = 233) of non-smokers, and smokers with and without COPD. The associations between the VDBP levels and the longitudinal decline of lung function were further analysed. Results: High frequencies of the haplotypes in rs7041/rs4588 were homozygous GC1S/1S (42.5%). Higher sputum VDBP levels in stage I and stage II COPD were observed only in carriers with GC1S/1S genotype when compared with non-smokers (p = 0.034 and p = 0.002, respectively). Genotype multivariate regression analysis indicated that the baseline sputum VDBP and FEV1/FVC ratio at baseline independently predicted FEV1% at follow-up. Discussion and Conclusion: The baseline sputum VDBP expression was elevated in smokers with COPD among individuals with the GC1S/1S genotype, and predicted followup airway obstruction. Our results suggest that the GC polymorphism should be considered when exploring the potential of VDBP as a biomarker for COPD.

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Vitamin D-binding protein gene polymorphisms and chronic obstructive pulmonary disease susceptibility: A meta-analysis

Cited by 11 publications

References 34 publications

Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD

Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD

Vitamin D deficiency is associated with the severity of COPD: a systematic review and meta-analysis

<p>Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD</p>

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