Vitamin D: Classic and Novel Actions

Gil, Ángel; Plaza‐Díaz, Julio; Mesa, María Dolores

doi:10.1159/000486536

Cited by 413 publications

(346 citation statements)

References 45 publications

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“…Vitamin D plays a role in calcium and phosphorus metabolism, thus contributing to bone growth and reorganisation. In addition, vitamin D plays a role in reducing oxidative stress, antimicrobial defence, immunoregulation, anti‐inflammation, anticancer properties, neuroprotective factors and child development …”

mentioning

confidence: 99%

Association of maternal vitamin D deficiency and infants' neurodevelopmental status: A cohort study on vitamin D and its impact during pregnancy and childhood in Indonesia

Dhamayanti

Noviandhari

Supriadi

et al. 2019

J Paediatrics Child Health

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Aim: Vitamin D deficiency in early pregnancy may cause the disruption of fetal brain development and neurodevelopmental function. This study aimed to explore the extent of neurodevelopment disruption could be associated with maternal vitamin D deficiency. Methods: A cohort study was conducted in Sukabumi and Waled, West Java, Indonesia, beginning in July 2016. Maternal serum 25(OH)-vitamin D was measured between 10 and 14 weeks of gestational age. Child development was measured using the Ages and Stages Questionnaire-3 (ASQ-3) at age 3, 6 and 12 months. Results: A total of 141 mother-infant pairs participated. One pair was excluded due to anencephaly of the infant. Vitamin D deficiency was found in 27 (19%) mothers, but delays occurred in gross motor function among 104 (76.1%) infants and in problem-solving functions among 61 (43.7%) infants at 3 months old. In general, the mean ASQ score at ages 3 and 6 months were lower among infants whose mothers had a vitamin D deficiency. The mean ASQ score for gross motor function at age 3 months was found to be significantly lower among these infants (31.5 vs. 37.9; P = 0.02), with increased risk for delayed motor function at age 3 months (relative risk (95% confidence interval) = 1.22 (1.09-1.49); P = 0.03). Conclusion: Neurodevelopmental function disruptions among infants whose mothers had vitamin D deficiency during pregnancy were reflected in lower ASQ scores, in which gross motor function was significantly impaired at 3 months of age. CovariateThe covariates in this study were maternal age, parity status, parents' education status (low, middle, high) and parental income. Characteristics of infants included gestational age, gender (male/female), exclusive breastfeeding (yes/no) and complementary feeding.

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mentioning

confidence: 99%

Association of maternal vitamin D deficiency and infants' neurodevelopmental status: A cohort study on vitamin D and its impact during pregnancy and childhood in Indonesia

Dhamayanti

Noviandhari

Supriadi

et al. 2019

J Paediatrics Child Health

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“…Current vitamin D analysis has focussed on measuring circulating vitamin D metabolites. However, most of the vitamin D actions occur within tissues and cell targets . Matrix‐assisted laser desorption/ionisation (MALDI)‐mass spectrometry imaging (MSI) is a technique that enables regional mapping/imaging of metabolites on tissue surfaces .…”

Section: Analytical Approaches For Vitamin D Analysismentioning

confidence: 99%

“…However, most of the vitamin D actions occur within tissues and cell targets. 41,[187][188][189] Matrix-assisted laser desorption/ionisation (MALDI)-mass spectrometry imaging (MSI) is a technique that enables regional mapping/imaging of metabolites on tissue surfaces. 190 Method development and applications of MALDI-MSI for vitamin D tissue analysis are limited.…”

Section: Vitamin D Conjugationmentioning

confidence: 99%

The vitamin D metabolome: An update on analysis and function

Jenkinson

2019

Cell Biochemistry & Function

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Current understanding of vitamin D tends to be focussed on the measurement of the major circulating form 25‐hydroxyvitamin D3 (25OHD3) and its conversion to the active hormonal form, 1α,25‐dihydroxyvitamin D3 (1α,25(OH)2D3) via the enzyme 25‐hydroxyvitamin D‐1α‐hydroxylase (CYP27B1). However, whilst these metabolites form the endocrine backbone of vitamin D physiology, it is important to recognise that there are other metabolic and catabolic pathways that are now recognised as being crucially important to vitamin D function. These pathways include C3‐epimerization, CYP24A1 hydroxylase, CYP11A1 alternative metabolism of vitamin D3, and phase II metabolism. Endogenous metabolites beyond 25OHD3 are usually present at low endogenous levels and may only be functional in specific target tissues rather than in the general circulation. However, the technologies available to measure these metabolites have also improved, so that measurement of alternative vitamin D metabolic pathways may become more routine in the near future. The aim of this review is to provide a comprehensive overview of the various pathways of vitamin D metabolism, as well as describe the analytical techniques currently available to measure these vitamin D metabolites.

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“…Recently, it has been reported that vitamin D metabolites naturally pass through the blood-brain barrier and they find easy access to neuronal and glial cells. Therefore, vitamin D plays significant role in neurological/neuromuscular disorders in addition to its antiaging property 37 .…”

Section: Ongoing Research and Future Directionsmentioning

confidence: 99%

Miraculous Physiological Activities of Vitamin D and Its Role in Human Health and Diseases

Chamoli¹,

Bahuguna²,

Painuly³

2019

Science and Culture

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Vitamin D, the sunshine vitamin or calciferol is endowed with the unique property of functioning as a hormone. Chemically, it is a secosterol produced in human skin from 7-dehydrocholesterol in presence of sunlight which contains ultraviolet-B radiations having the wavelength ranging from 290 to 320 nanometer (nm). In addition to exposure of body to sunlight, diet and dietary supplements are also sources of vitamin D to human beings. It is well known that vitamin D has a crucial role in calcium-phosphate homeostasis and in the maintenance of healthy bones and teeth. The discovery of vitamin D receptors (VDR) in almost all the vital organs of human body has opened a new era in vitamin D research. New researches have revealed that besides the known sketal functions, vitamin D is involved in large number of other biological functions.

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Vitamin D: Classic and Novel Actions

Cited by 413 publications

References 45 publications

Association of maternal vitamin D deficiency and infants' neurodevelopmental status: A cohort study on vitamin D and its impact during pregnancy and childhood in Indonesia

Association of maternal vitamin D deficiency and infants' neurodevelopmental status: A cohort study on vitamin D and its impact during pregnancy and childhood in Indonesia

The vitamin D metabolome: An update on analysis and function

Miraculous Physiological Activities of Vitamin D and Its Role in Human Health and Diseases

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