Vitamin D, cod liver oil, sunshine, and phototherapy: Safe, effective and forgotten tools for treating and curing tuberculosis infections — A comprehensive review

McCullough, Patrick J.; Lehrer, Douglas S.

doi:10.1016/j.jsbmb.2017.07.027

Cited by 30 publications

(43 citation statements)

References 54 publications

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“…Prospective randomized controlled clinical trials should be performed with respect to these comorbidities of psoriatic patients to evaluate potential additive or synergistic effects as a viable treatment option. 31 , 43 …”

Section: Discussionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis

Amon¹,

Baier²,

Yaguboglu³

et al. 2018

Dermato-Endocrinology

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The pathogenetic role of vitamin D as well as its clinical correlation in inflammatory skin diseases is still uncertain. This study aimed to compare serum levels of 25(OH) vitamin D (calcidiol) in outpatients suffering from different skin diseases using the same laboratory method in one study. In routine serum samples of 1,532 patients from the previous 12 months we identified retrospectively 180 (mean age 49.4 years, 80 female, 100 male) and 205 (mean age 36.3 years, 116 female, 89 male) patients with psoriasis (PSO) and atopic dermatitis (AD), respectively. Clinical disease activity and quality of life was evaluated using Physicians Global Assessment Scores (PGA), Dermatology Life Quality Index (DLQI), and a Visual Analog Scale for pruritus in AD, respectively. The median 25(OH)D serum level of all patients (22.97 ng/mL, range 2.61–96.0, n = 1,461) was significantly lower in comparison to healthy controls (41.6 ng/mL, range 16.9–77.57, p < 0.0001, n = 71). In PSO and AD we measured 21.05 ng/mL (44% < 20 ng/mL) and 22.7 ng/mL (39% < 20 ng/mL), respectively (p = 0.152). Among all subgroups, patients with severe acute or chronic infectious skin diseases had the lowest median 25(OH)D serum levels (17.11 ng/mL, n = 94, 66% <20 ng/mL, p < 0,001 vs. AD, p = 0,007 vs. PSO). For PSO and AD there was no significant correlation between 25(OH)D levels and PGA scores and DLQI values, respectively, or the extent of pruritus in AD. 25(OH)D serum levels in inflammatory skin diseases might correlate more with the type of disease and the degree of inflammation than with clinical activity itself.

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Section: Discussionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis

Amon¹,

Baier²,

Yaguboglu³

et al. 2018

Dermato-Endocrinology

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“…In the 1940s TB treatment began to shift with the discovery of vitamin D. Independently vitamin D has been proven to cure infections without using penicillin simultaneously. Until 1947 the first anti-TB drug was discovered by Dr. Selman Waksman, this is changing all TB treatments that have been used and are now almost forgotten (McCullough, 2018). The main advantage of TB antibiotics is the ability to avoid prolonged hospitalization and does not require long maintenance costs (McCullough, 2015).…”

Section: Discussionmentioning

confidence: 99%

Effects Of Sunlight Exposure For Treatment of Tuberculosis : Literature Review

Wijaya

Makiyah

2020

JNP

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Background: Tuberculosis is a contagious infectious disease caused by Mycobacterium. Tuberculosis which can attack various organs, especially the lungs. It is necessary to study the effectiveness of sunlight therapy and the vitamin D diet as supporting tuberculosis treatment.Objective: This study aimed at investigating the literature for of provision of sunlight in tuberculosis patients.Method: This library review uses a database with the electronic search on Ebsco, ClinicalKey, Google Scholar, and ScienceDirect published in 2016 - 2019.Results: Six articles were used to review. The article discusses vitamin D deficiency as a causative factor for tuberculosis, the effectiveness of clinical treatment in a sanatorium using vitamin D and the use of sunlight as a treatment for tuberculosis in the days before the discovery of antibiotics.Conclusion: Sun exposure has been shown to provide a clinical improvement in patients by providing comfort and improving moods that are unable to increase the elimination of bacteria in the lungs.Conclusion: This therapy provides clinical improvement to the patient and provides a calm sensation and improves mood even though it has not been able to eliminate the bacteria in the lungs until anti-TB drugs are found and this sunlight therapy is forgotten.

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“…A negative relationship between duration of sunshine and TB reported incidence was observed, which is consistent with the findings of other recent studies. 33,34 It means that the less someone exposure in the sunshine, the higher risk of the TB he/she get. A mechanism for this relationship is that decreased vitamin D levels with consequent impaired host defense arising from reduced sunshine exposure.…”

Section: Discussionmentioning

confidence: 99%

Detecting spatiotemporal pattern of tuberculosis and the relationship between ecological environment and tuberculosis, a spatial panel data analysis in Guangxi, China

Lin

Chongsuvivatwong

et al. 2018

Preprint

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Guangxi is one of the provinces having the highest reported incidence of tuberculosis (TB) in China. However, spatial and temporal pattern and causation of the situation are still unclear. In order to detect the spatiotemporal pattern of TB and the association with ecological environment factors in Guangxi Zhuang autonomous region, China, We performed a spatiotemporal analysis with prediction using time series analysis, Moran's I global and local spatial autocorrelation statistics, and space-time scan statistics, to detect temporal and spatial clusters. Spatial panel models were employed to identify the influence factors. The time series analysis shows that the number of reported cases peaked in spring and summer and decreased in autumn and winter with the annual reported incidence of 113.1/100,000 population. Moran's I global statistics were greater than 0 (0.363 -0.536) during the study period. The most significant hot spots were mainly located in the central part. The east part exhibited a low-low relation. By spacetime scanning, the clusters identified were similar to that of the local autocorrelation statistics, and were clustered toward the early of 2016. Duration of sunshine, per capita gross domestic product (PGDP), the recovery rate of TB and participation rate of new cooperative medical care insurance in rural areas had a significant negative association with TB. In conclusion, the reported incidence of TB in Guangxi remains high. The main cluster was located in the central part of Guangxi, a region where promoting the productivity, improving TB treatment pathway and strengthening environmental protective measures (increasing sunshine exposure) are urgently needed.

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Vitamin D, cod liver oil, sunshine, and phototherapy: Safe, effective and forgotten tools for treating and curing tuberculosis infections — A comprehensive review

Cited by 30 publications

References 54 publications

Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis

Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis

Effects Of Sunlight Exposure For Treatment of Tuberculosis : Literature Review

Detecting spatiotemporal pattern of tuberculosis and the relationship between ecological environment and tuberculosis, a spatial panel data analysis in Guangxi, China

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