Vitamin D deficiency among apparently healthy children and children with common medical illnesses in Sub-Saharan Africa: A systematic review and meta-analysis

Shaka, Mohammed Feyisso; Kabthymer, Robel Hussen; Meshesha, Meiraf Daniel; Borde, Moges Tadesse

doi:10.1016/j.amsu.2022.103403

Cited by 3 publications

(1 citation statement)

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“…21 A study by Shaka MF et al in apparently healthy children noted that 50.1% children had VDD. 22 All these studies show that VDD is quite high among pediatric population. More alarmingly, the present studies have shown that VDD affects vast majority of healthy children.…”

Section: Discussionmentioning

confidence: 98%

Frequency of vitamin D deficiency in admitted children 6 -36 months of age at Sahiwal Teaching Hospital Sahiwal, Punjab, Pakistan.

Faisal¹,

Sajid²,

Yasin³

et al. 2023

TPMJ

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Objective: To find out the frequency of vitamin D deficiency (VDD) in healthy children. Study Design: Cross-sectional study. Setting: Department of Pediatric Medicine, Sahiwal Teaching Hospital, Sahiwal. Period: July 2022 to December 2022. Material & Methods: A total of 80 healthy children of either gender aged 6 to 36 months visiting outpatients department of pediatrics during the study period adopting convenient sampling technique were included. At the time of enrollment, demographic information was recorded and blood sample was obtained and sent for vitamin D analysis. The frequency of VDD was noted. Results: In a total of 80 children, 48 (60.0%) were boys and 32 (40.0%) girls. The mean age was of 14.4±6.2 months. Residential status of 47 (58.3%) children was rural. Evaluation of vitamin D status revealed that 16 (20.0%) children had sufficient levels while deficiency and severe deficiency were noted in 44 (55.0%) and 20 (25.0%) children respectively. Younger age group was having significant linkage with VDD (p=0.0135). Conclusion: The frequency of vitamin D deficiency was very high among healthy children visiting a tertiary care health facility of Punjab, Pakistan. Younger age groups had significant association with the occurrence of vitamin D deficiency.

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Section: Discussionmentioning

confidence: 98%

Frequency of vitamin D deficiency in admitted children 6 -36 months of age at Sahiwal Teaching Hospital Sahiwal, Punjab, Pakistan.

Faisal¹,

Sajid²,

Yasin³

et al. 2023

TPMJ

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Vitamin D3 supplementation as an adjunct in the management of childhood infectious diarrhea: a systematic review

et al. 2023

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Background Some studies have reported the possible role of vitamin D3 in ameliorating disease outcomes in childhood infectious diarrhea. However, findings about its effectiveness and the association of serum vitamin D levels with diarrhea risk appear inconsistent. We aimed to determine the efficacy of oral vitamin D3 as an adjunct in managing childhood infectious diarrhea and the relationship between vitamin D status and the disease. Methods We searched the PubMed and Google Scholar electronic databases for relevant articles without limiting their year of publication. We selected primary studies that met the review’s inclusion criteria, screened their titles and abstracts, and removed duplicates. We extracted data items from selected studies using a structured data-extraction form. We conducted a quality assessment of randomized controlled trials (RCTs) and non-randomized studies with the Cochrane collaboration tool and the Newcastle Ottawa Scale, respectively. We assessed the strength of the relationship between serum vitamin D levels and diarrhea using the correlation model. We estimated the I2 and tau2 values to assess between-study heterogeneity. Results Nine full-text articles were selected, consisting of one RCT, three cross-sectional studies, two cohort studies, two longitudinal/prospective studies, and one case-control study. A total of 5,545 participants were evaluated in the nine studies. Six non-randomized studies provided weak evidence of the relationship between vitamin D levels and diarrhea risk as there was no correlation between the two variables. The only RCT failed to demonstrate any beneficial role of vitamin D3 in reducing the risk of recurrent diarrhea. The calculated I2 and tau2 values of 86.5% and 0.03, respectively suggested a high between-study heterogeneity which precluded a meta-analysis of study results. Conclusion Oral vitamin D3 may not be an effective adjunct in managing childhood infectious diarrhea. Additionally, the relationship between vitamin D status and infectious diarrhea appears weak. We recommend more adequately-powered RCTs to determine the effectiveness of vitamin D3 as an adjunct therapy in infectious diarrhea.

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Pathogenesis, Diagnostic Challenges, and Risk Factors of Pott’s Disease

Glassman

Nguyen

Giess

et al. 2023

Clinics and Practice

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Tuberculosis (TB) prevalence is increasing in developed nations and continuing to cause significant mortality in low- and middle-income countries. As a result of the uptick in cases, there also exists an increased prevalence of extrapulmonary TB. TB is caused by Mycobacterium tuberculosis (M. tb). When M. tb disseminates to the vertebral column, it is called Pott’s disease or spinal TB. The frequency, symptoms, and severity of the disease range by the location of the spine and the region of the affected vertebrae. While the current literature shows that timely diagnosis is crucial to reduce the morbidity and mortality from Pott’s disease, there is a lack of specific clinical diagnostic criteria for Pott’s disease, and the symptoms may be very non-specific. Studies have shown that novel molecular diagnostic methods are effective and timely choices. Research has implicated the risk factors for the susceptibility and severity of Pott’s disease, such as HIV and immunosuppression, poverty, and malnutrition. Based on the current literature available, our group aims to summarize the pathogenesis, clinical features, diagnostic challenges, as well as the known risk factors for Pott’s disease within this literature review.

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Vitamin D deficiency among apparently healthy children and children with common medical illnesses in Sub-Saharan Africa: A systematic review and meta-analysis

Cited by 3 publications

References 46 publications

Frequency of vitamin D deficiency in admitted children 6 -36 months of age at Sahiwal Teaching Hospital Sahiwal, Punjab, Pakistan.

Frequency of vitamin D deficiency in admitted children 6 -36 months of age at Sahiwal Teaching Hospital Sahiwal, Punjab, Pakistan.

Vitamin D3 supplementation as an adjunct in the management of childhood infectious diarrhea: a systematic review

Pathogenesis, Diagnostic Challenges, and Risk Factors of Pott’s Disease

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