Vitamin D deficiency in early life regulates gut microbiome composition and leads to impaired glucose tolerance in adult and offspring rats

Liu, Fei; Liu, Junyi; Zhang, Jingyi; Liu, Chunyan; Qu, Chunbo; Na, Lixin

doi:10.1039/d3fo00503h

Cited by 10 publications

(1 citation statement)

References 78 publications

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“…In rats, vitamin D deficiency impaired glucose tolerance and increased D esulfovibrio, Peptococcus, Roseburia, Lachnopriraceae, Lachnoclostridium , and Ruminiclostridium . Blautia linked to 2-picolinic acid was decreased, leading to a decrease in the metabolite that is crucial in generating an immunological response ( 227 ).…”

Section: Bioactives and Osteoarthritis: Metabolic And Anti-inflammato...mentioning

confidence: 99%

Bioactives and their roles in bone metabolism of osteoarthritis: evidence and mechanisms on gut-bone axis

Basak,

Hridayanka,

Duttaroy

2024

Front. Immunol.

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Bioactives significantly modify and maintain human health. Available data suggest that Bioactives might play a beneficial role in chronic inflammatory diseases. Although promised, defining their mechanisms and opting to weigh their benefits and limitations is imperative. Detailed mechanisms by which critical Bioactives, including probiotics and prebiotics such as dietary lipids (DHA, EPA, alpha LA), vitamin D, polysaccharides (fructooligosaccharide), polyphenols (curcumin, resveratrol, and capsaicin) potentially modulate inflammation and bone metabolism is limited. Certain dietary bioactive significantly impact the gut microbiota, immune system, and pain response via the gut-immune-bone axis. This narrative review highlights a recent update on mechanistic evidence that bioactive is demonstrated demonstrated to reduce osteoarthritis pathophysiology.

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Section: Bioactives and Osteoarthritis: Metabolic And Anti-inflammato...mentioning

confidence: 99%

Bioactives and their roles in bone metabolism of osteoarthritis: evidence and mechanisms on gut-bone axis

Basak,

Hridayanka,

Duttaroy

2024

Front. Immunol.

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'Nine Steaming Nine Sun‐drying' processing enhanced properties of Polygonatum kingianum against inflammation, oxidative stress and hyperglycemia

Zhou,

Liu,

Yan

et al. 2023

J Sci Food Agric

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BACKGROUNDPolygonatum kingianum Coll. & Hemsl (PK), a prominent medicine and food homology plant, has been consumed as a decoction from boiling water for thousands of years. 'Nine Steaming Nine Sun‐drying' processing has been considered an effective method for enriching tonic properties, but studies investigating such impacts on PK and underlying mechanisms are extremely rare.RESULTSWe first demonstrated substantial improvements in the anti‐oxidative, anti‐inflammatory and anti‐hyperglycemia effects of the Nine Steaming Nine Sun‐drying processed PK water extracts compared with crude PK in cell models (i.e., HepG2 and Raw 264.7 cells). We then integrated foodomics and network pharmacology analysis to uncover the key compounds responsible for the improved benefits. A total of 551 metabolites of PK extracts were identified, including polyphenols, flavonoids, alkaloids, and organic acids. During processing, 204 metabolites were enhanced, and 32 metabolites were recognized as key constituents of processed PK responsible for the improved health‐promoting activities, which may affect PI3K‐Akt‐, MAPK‐, and HIF‐1 pathways. We further confirmed the high affinity between identified key constituents of processed PK and their predicted acting targets using molecular docking.CONCLUSIONOur results provide novel insights into bioactive compounds of processed PK, elaborating the rationality of processing from the perspective of tonic effects. Consuming processed PK could be an efficacious strategy to combat the high prevalence of metabolic diseases that currently affect millions of people worldwide. © 2023 Society of Chemical Industry.

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Exploring the mechanism of action of Rosa roxburghii Tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomics

Zhao,

Zhu,

Nie

et al. 2025

Journal of Functional Foods

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Vitamin D deficiency in early life regulates gut microbiome composition and leads to impaired glucose tolerance in adult and offspring rats

Abstract: Vitamin D is found involved in glucose metabolism in recent years. Vitamin D deficiency is very common especially in children. Whether vitamin D deficiency in early life affects adult diabetes...

Cited by 10 publications

References 78 publications

Bioactives and their roles in bone metabolism of osteoarthritis: evidence and mechanisms on gut-bone axis

Bioactives and their roles in bone metabolism of osteoarthritis: evidence and mechanisms on gut-bone axis

'Nine Steaming Nine Sun‐drying' processing enhanced properties of Polygonatum kingianum against inflammation, oxidative stress and hyperglycemia

Exploring the mechanism of action of Rosa roxburghii Tratt quercetin in ameliorating type 2 diabetes in mice based on the intestinal microbiome and metabolomics

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