Vitamin D deficiency in sickle cell disease patients in the Eastern Province of Saudi Arabia

Al‐Jam'a, Ali H.; Alkhalifah, Mohammed; Al-Dabbous, Ibrahim A.; Alqudaihi, Ghada

doi:10.5144/0256-4947.2018.130

Cited by 14 publications

(13 citation statements)

References 44 publications

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“…A deficiência de vitaminas é uma das condições nutricionais mais comuns entre pessoas com DF, e existem características específicas que podem contribuir para esse fenômeno. Uma delas é a falta de apetite que pode ocorrer na presença da doença e em pacientes hospitalizados, além da produção constante de glóbulos vermelhos para compensar a sobrevivência reduzida de glóbulos vermelhos (Aljama et al, 2018).…”

Section: Nutrientesunclassified

“…Evidenciase, na literatura, uma alta prevalência de complicações endócrinas e alterações metabólicas na população com DF, sendo a vitamina D a condição mais detectada relacionada à hipovitaminose. Há, também, uma relação negativa significativa entre níveis plasmáticos de vitamina D e gravidade clínica da doença, representada pelo número de internações (Dougherty et al, 2015;Aljama et al, 2018;Mandese et al, 2019).…”

Section: Nutrientesunclassified

“…Tais fatores podem agravar ou determinar a falha no desenvolvimento de crianças e adolescentes com DF (Cehmob, 2018). Além da vitamina D ser vital para a saúde óssea e para a manutenção do cálcio, é responsável também por manter o nível de fosfato sérico normal, bem como efeito importante na função imune, proliferação celular, diferenciação e apoptose (Aljama et al, 2018).…”

Section: Nutrientesunclassified

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Promoção da saúde nutricional em adolescente com doença falciforme: Estudo de caso único

Meneghini

Netto

2021

RSD

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O objetivo deste trabalho é descrever o perfil nutricional e clínico de um adolescente com doença falciforme, considerando o consumo de macro e micronutrientes, baseado nos hábitos alimentares e avaliação antropométrica. Trata-se de um estudo de caso único de um adolescente, sexo masculino, 16 anos de idade, diagnosticado com doença falciforme, sustentado no referencial teórico da dialética. A justificativa para o estudo se deu pela identificação da falha no acompanhamento nutricional de adolescentes com doença falciforme no Programa de Residência Multiprofissional em Saúde do Adolescente da Universidade Federal de São João del-Rei, Campus Centro-Oeste. A coleta de dados foi realizada no período de dezembro de 2020 a janeiro de 2021. Acredita-se que este estudo possa trazer benefícios de curto, médio e longo prazo para os adolescentes com doença falciforme, para suas famílias, para a comunidade, para as instituições formadoras e para a ciência, uma vez que a identificação do estado nutricional dos adolescentes com a doença falciforme, favorece o planejamento de ações voltadas para a promoção da saúde, de modo a minimizar o prejuízo para a qualidade de vida em todo o ciclo de vida do adolescente.

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Section: Nutrientesunclassified

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Promoção da saúde nutricional em adolescente com doença falciforme: Estudo de caso único

Meneghini

Netto

2021

RSD

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“…The reported incidences of VDD range from 20 to 80% in some Middle Eastern counties [ 21 ]. Despite these high incidences, VDD often remained underdiagnosed and untreated especially in patients with SCD where chronic pain of VDD was usually credited to SCD, as the pain in both conditions is dull aching and deeply seated and involves the back and extremities [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Nonskeletal Complications among Egyptian Sickle Cell Disease Patients

Hamdy

Salama

Maher

et al. 2018

Advances in Hematology

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Lower levels of vitamin D have been documented in many patients with sickle cell disease (SCD), but data are still inconclusive regarding the association between vitamin D deficiency (VDD) and the occurrence or the severity of various SCD complications. Our study aimed to detect the prevalence of vitamin D deficiency among Egyptian patients with SCD and to associate it with the clinical course of the disease. We measured the level of 25-hydroxy vitamin D in 140 children (age from 4.3 to 15.5years), 80 patients with SCD and 60 controls using enzyme-linked immunosorbent assay. Vitamin D was deficient in 60% of SCD compared to 26.7% of controls. Severe VDD was significantly higher in SCD patients than controls. Patients were divided into 2 groups; Normal group (32 patients) and Deficient group (48 patients). There were statistically significant differences between the 2 groups regarding their age, height percentile, the presence of clinical jaundice, and osseous changes (P values 0.043, 0.024, 0.001, and 0.015, respectively). Hemoglobin and hematocrit values were significantly lower in Deficient group (P values 0.022 and 0.004, respectively) while the levels of aspartate aminotransferase, lactate dehydrogenase, and total and indirect bilirubin were significantly higher in the same group (P values 0.006, 0.001, 0.038, and 0.016, respectively). The frequency of blood transfusions, hospitalization, and vasoocclusive crisis previous year as well as the history of bone fracture and recurrent infections proved to be significantly higher in Deficient group. These findings suggest that VDD may play a role in the pathogenesis of hemolysis and other complication of SCD. Vitamin D monitoring and supplementation in patients with SCD should be implemented as a standard of care to potentially improve health outcomes in these affected patients.

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“…Full texts of 40 studies were screened, and 15 studies were subsequently excluded because of insufficient data to estimate the outcomes of interest (Figure 1). A total of 25 studies published from 1993 to 2019 that met the eligibility for data were used for qualitative and quantitative syntheses: 10 studies from the Americas [12,[28][29][30][31][32][33][34][35][36]; six studies from Asia [37][38][39][40][41][42]; five studies from Europe [43][44][45][46][47]; two studies from Africa [48,49], one study that used samples from both Jamaica and West Africa [50], and one study that used samples from both Brazil and Nigeria [51].…”

Section: Studies Includedmentioning

confidence: 99%

A Meta-analysis on Vitamin D Deficiency in Patients with Sickle Cell Disease

Mohamed¹,

MohamedElmugadam²,

Awadalla³

et al. 2020

DSAHMJ

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Vitamin D Deficiency (VDD) is reported to be more frequent with serious clinical outcomes in patients with Sickle Cell Disease (SCD). There is a wide disparity in data in the existing literature regarding the prevalence and risk of VDD in patients with SCD. These data require further summary and analyses for better accuracy. This review aimed to assess the association between VDD and SCD, and was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Medline/ PubMed, World Health Organization Virtual Health Library, ScienceDirect, and Google Scholar were used for the systematic search. A random effects model was used to estimate the pooled prevalence, Risk Ratio (RR), and Standardized Mean Difference (SMD) estimates with the corresponding 95% Confidence Interval (CI) using OpenMeta Analyst software version 10.10 (Tufts Medical Center, Boston, MA, USA). Twenty-five studies fulfilled the eligibility criteria. The prevalence of VDD among patients with SCD was 63.8% (95% CI, 52.5-75.1). The risk of VDD among patients with SCD was more than two times that of the general population (RR = 2.129; 95% CI, 1.024-4.423; p < 0.001). Serum vitamin D levels were significantly lower in SCD patients than in their controls (SMD = −1.883: 95% CI, −3.006 to −0.760; p < 0.001). This review provides a comprehensive view of the association between vitamin D status and SCD.

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Vitamin D deficiency in sickle cell disease patients in the Eastern Province of Saudi Arabia

Cited by 14 publications

References 44 publications

Promoção da saúde nutricional em adolescente com doença falciforme: Estudo de caso único

Promoção da saúde nutricional em adolescente com doença falciforme: Estudo de caso único

Vitamin D and Nonskeletal Complications among Egyptian Sickle Cell Disease Patients

A Meta-analysis on Vitamin D Deficiency in Patients with Sickle Cell Disease

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