Vitamin D deficiency is a problem for adult out-patients? A university hospital sample in Istanbul, Turkey

Abstract

Objective: To investigate the frequency of vitamin D deficiency in relation to demographics, clinical diagnosis, season of measurement and laboratory parameters in adult out-patients. Design: Descriptive, retrospective study concerning evaluation of the initial 25-hydroxyvitamin D (25(OH)D) levels determined at admission in relation to demographics, clinical diagnosis, season of measurement and laboratory parameters. 25(OH)D levels ,20 ng/ml were classified as deficiency, 20-30 ng/ml as insufficiency and .30 ng/ml as sufficiency. Setting: Out-patient clinics at a tertiary care centre. Subjects: A total of 2488 adult patients (mean age: 53?3 (SD 15?2) years; 85?2 % were females) admitted to out-patient clinics at Baskent University Istanbul Hospital were included. Results: Mean level of 25(OH)D in the overall population was 17?4 (SD 11?5) ng/ml while insufficiency and deficiency were evident in 24 % and 66 % of patients, respectively. Mean 25(OH)D levels in males .45 years old were higher than in their female counterparts (19?4 (SD 11?3) ng/ml v. 17?8 (SD 12?2) ng/ml; P , 0?05). Mean 25(OH)D levels obtained in summer (18?6 (SD 11?1) ng/ml) and autumn (23?3 (SD 13?6) ng/ml) were significantly higher than levels in spring (16?1 (SD 10?3) ng/ml) and winter (14?6 (SD 10?2) ng/ml; P , 0?01). Mean 25(OH)D levels were determined to be significantly lower in obese patients compared with non-obese patients (15?6 (SD 10?4) ng/ml v. 17?6 (SD 11?6) ng/ml; P , 0?05). Levels of 25(OH)D were significantly negatively correlated with serum parathyroid hormone levels (r 5 20?194; P , 0?001) while significantly positively correlated with phosphorus (r 5 0?059; P , 0?01) and HDL cholesterol (r 5 0?070; P , 0?01) levels. Conclusions: Our findings indicate that vitamin D deficiency is very common among out-patients in Turkey, regardless of gender and age, especially among obese people and during winter and spring.

Independent factors associated with serum levels of 25- Hydroxyvitamin D in very elderly Chinese males

“…Apolipoprotein A1 is the main structural protein of high density lipoprotein. It can catalyze lecithin cholesterol acyltransferase, transport dermal vitamin D to the liver to be transformed into 25(OH)D by 25-hydroxylase [32]. In addition, triglycerides (β=-1.868, P=0.009) was found to be an independent factor negatively associated with serum 25(OH)D in the present study.…”

Analysis of Vitamin D and Calcium Levels in Benign Paroxysmal Positional Vertigo

“…A study that investigated the vitamin D levels in Europe and Asia reported that Middle Eastern countries, including Turkey, have very low vitamin D levels (14). The study by Ciğerli et al (15), which was conducted in Turkey, examined 2488 adult outpatients and found the mean vitamin D level to be 17.4±11.5 ng/mL. The study showed that 24% of the patients had vitamin D deficiency, 66% had vitamin D inadequacy, and the vitamin D inadequacy increased, particularly during the autumn and winter months.…”

Bone mineral density measurements in otosclerosis using dual‐energy X‐ray absorptiometry

“…Both groups are slightly deficient in vitamin D levels; however, the difference was insignificant. This finding may result from the fact that vitamin D deficiency is very common in our population …”