Vitamin D Effects on Guided Bone Regeneration and Osseointegration of Dental Implants (Literature Review)

Ivanov, S. Yu.; Kalinchenko, Svetlana; Guseynov, N. A.; Мураев, А. А.; Safi, Aigul; Polyakov, Kirill; Smykalova, Anastasiya S.

doi:10.15690/vramn1376

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…These facts are a prerequisite for the use of vita min D 3 in IBD [4]. At the moment, there are no dosage forms with vitamin D 3 in the Russian Federation for local use per rectum, taking into account the impact on the focus of inflammation and the damaged area of the colon in IBD.…”

Section: Introductionmentioning

confidence: 99%

Clinical and immunological analysis of the effectiveness of local application of vitamin D<sub>3</sub> in experimental colitis

et al. 2023

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The pathogenesis of inflammatory bowel diseases has not been fully studied, and the therapies used have side effects that limit their use.The purpose of this study is to conduct a clinical and immunological analysis of the effectiveness of vitamin D3 in the original rectal suppositories in experimental colitis (EC).EC was modeled with oxazolone. Original suppositories with vitamin D3 in group 3 and 5-ASA in group 4 were used per rectum. The clinic was evaluated on the Disease activity index scale. The expression of MPO and TNFa, the content of neutrophils, lymphocytes, eosinophils, histiocytes, plasmocytes, fibroblasts, ulcerative defect, tissue damage index were determined in the focus of colon injury. The study was carried out on days 2, 4 and 6.With EC, DAI increases for the entire day, MPO and TNFa increase in the lesion, ulcerative defect isfixed, neutrophil-lymphocytic infiltration increases, and TDI increases. When comparing the morphometric parameters of the alteration zone in EC under the conditions of vitamin D3 use, in contrast to the use of 5-ASA, a decrease in the number of lymphocytes, an increase in fibroblasts was revealed on day 2, a decrease in the number of plasmocytes and an increase in fibroblasts on day 4, an increase in the number of histiocytes and fibroblasts on day 6. The diameter of the ulcerative defect and the TDI index have no significant differences between the compared groups. When comparing the effectiveness of vitamin D3, in contrast to the use of 5-ASA, the MPO content is higher on day 6; the TNFa content is higher on day 4.In EC, the effects of using rectal suppositories with vitamin D3 on clinical signs, the size of the ulcerative defect, the content of MPO and TNFa in the lesion are comparable to the effects of using rectal suppositories with 50 mg of 5-ASA; more pronounced with respect to the dynamics of the cellular composition of the lesion of the colon.

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Section: Introductionmentioning

confidence: 99%

Clinical and immunological analysis of the effectiveness of local application of vitamin D<sub>3</sub> in experimental colitis

et al. 2023

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Experimental evaluation of the efficacy of tissue-engineered constructs in the treatment of limbal stem cell deficiency

Andreev,

Yu,

Rogovaya

et al. 2024

Rus. Ann. Ophthal.

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Optimization of the dental implantation protocol in patients with partial secondary edentulousness and vitamin D deficiency

Ostrovskaya

Zakharova

Lysov

et al. 2021

Medicinskij alfavit

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Relevance. The processes of osseointegration in the area of dental implant placement are accompanied by the development of reactions associ-ated with inflammation and activation of local immune processes in peri-implant tissues. Vitamin D preparations can have a significant local effect on the cells of the innate immune defense of the periodontal tissues.The aim of this work is to study the effectiveness of local application of vitamin D on the immune status of the peri-implant sulcus in rehabilitation of patients with partial secondary edentulous and chronic periodontitis by the method of dental implantation.Materials and methods. Determination of the content of biomarkers (IL-1RA, MCP-1, VEGF, TGF-β1, sTNFR) in the crevicular fluid before the installation of implants and the peri-implantation furrow fluid was carried out by the method of enzyme-linked immunosorbent assay using commercial kits «Vector Best» reagents after 3 and 6 months after surgery. The assessment of the state of the bone tissue was carried out using the Orthopantomograph tm OP300 apparatus (KAVO Dental, Germany). Vitamin D has been used topically at a therapeutic dosage.Results. Vitamin D, by reducing Th-1 and Th-17 cell proliferation and differentiation, blocks the activity of the immune-inflammatory process that occurs during implant placement.Conclusion. Application of colecalciferol in patients with moderate periodontitis leads to the activation of the production of immunoregulatory cyto-kines by the cellular structures of the peri-implantation furrow and can be used in combination with the traditional protocol in this category of patients.

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Vitamin D Effects on Guided Bone Regeneration and Osseointegration of Dental Implants (Literature Review)

Cited by 3 publications

References 32 publications

Clinical and immunological analysis of the effectiveness of local application of vitamin D<sub>3</sub> in experimental colitis

Clinical and immunological analysis of the effectiveness of local application of vitamin D<sub>3</sub> in experimental colitis

Experimental evaluation of the efficacy of tissue-engineered constructs in the treatment of limbal stem cell deficiency

Optimization of the dental implantation protocol in patients with partial secondary edentulousness and vitamin D deficiency

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