Vitamin D Efficiency in Pregnancy: An Updated Viewpoint in Indian Scenario

Maladkar, Manish; Sankar, Srividya; Kamat, Kushal

doi:10.4236/ijcm.2015.63026

Cited by 5 publications

(3 citation statements)

References 85 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Conflicting information regarding PTH concentrations in pregnancy[ 18 19 20 ] may reflect the use of antibodies with different specificities to PTH and the heterogeneity of inactive fragments of the hormone that result from peripheral metabolism and from increased glomerular filtration that occur in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional study of serum parathyroid hormone level in high-risk pregnancies as compared to nonpregnant control

Sharma

Usha

et al. 2016

Indian J Endocr Metab

View full text Add to dashboard Cite

Objectives:To note the value of serum parathyroid hormone (PTH) levels in normal and high-risk pregnancies (HRP) in patients attending antenatal visits at All India Institute of Medical Sciences (AIIMS).Materials and Methods:This is a cross-sectional study where a total of 282 patients attending Gynecology Outpatient Department at AIIMS, New Delhi were recruited. Among the 282 subjects, 251 were pregnant, and 31 were controls. The serum was tested for serum PTH levels using Beckman coulter access 2 immunoassay.Results:The median value of PTH level in pregnant women was 31.6 pg/ml with range being 0.8–505.5 pg/ml in contrast to 45.9 pg/ml with range being 19–102.7 pg/ml in nonpregnant female. This difference was statistically significant (P = 0.0012). There was no significant difference in median level of PTH in different age group. Although the median PTH levels were lower in second trimester (25.25 pg/ml) than in first trimester (35.5 pg/ml) and in third trimester (32.4 pg/ml), the difference was not statistically significant. There was no significant difference in PTH level in HRP (median value – 31.6 pg/ml) as compared to low-risk pregnancies (31.5 pg/ml).Conclusion:Serum PTH levels are significantly lower during pregnancy as compared to nonpregnant state. However, age, parity, and HRP did not alter PTH level during pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Cross-sectional study of serum parathyroid hormone level in high-risk pregnancies as compared to nonpregnant control

Sharma

Usha

et al. 2016

Indian J Endocr Metab

View full text Add to dashboard Cite

show abstract

“…если процессы остеосинтеза и остеорезорбции уравновешены, уровень ПТг остается на нижней границе нормы или отмечается уменьшение его концентрации. Первоначально считали, что лактация представляет собой состояние вторичного гиперпаратиреоза [6,7], хотя некоторые результаты анализа ПТг подтвердили эту гипотезу [8], в большинстве случаев уровень ПТг был нормальным [9]. в настоящем исследовании, уровень ПТг оставался в пределах референтных значений, однако отмечается повышение уровня ПТг, в наибольшей степени через 3 и 6 мес.…”

Section: результатыunclassified

Vitamin D and mineral metabolism after childbirth with the use of preventive doses of cholecalciferol

Novikova¹,

Dedov²,

Кузнецова³

et al. 2019

Z.akus.zen.bolezn

View full text Add to dashboard Cite

Hypothesis/aims of study. According to the literature, the prevalence of vitamin D deficiency and its deficiency in pregnant women reaches 6080%, which is a significant factor in reducing bone mineral density (BMD), osteopenia, and the risk of fractures after childbirth. Hormone-mediated changes in calcium-phosphorus metabolism during lactation are an independent factor in the reduction of BMD. Therefore, the study of the relationship between vitamin D deficiency and insufficiency after childbirth and the possibility of correction is relevant. The aim of this study was to evaluate the effect of prophylactic doses of cholecalciferol and calcium carbonate over time on calcium-phosphorus metabolism indicators after childbirth. Study design, materials and methods. A randomized controlled trial was conducted based on V.A. Almazov National Medical Research Center, Saint Petersburg. 64 puerperas, who lived in St. Petersburg from 2013 to 2014, were surveyed on the 35th day after childbirth. The age of women ranged from 20 to 35 years. Blood serum levels of calcium, phosphorus, magnesium, 25-hydroxycalciferol (25(OH)D), and parathyroid hormone (PTH) were determined for all the puerpera. Using the blind envelope method, the postpartum women were randomized into groups: group I received cholecalciferol 400 IU and calcium carbonate 1000 mg after delivery for 6 months; group II received cholecalciferol 900 IU and calcium carbonate 1000 mg after delivery for 6 months. Blood sampling was performed over time to assess the levels of 25(OH)D, PTH, calcium, phosphorus, and magnesium. Results. In group I after childbirth, the initial level of 25(OH)D in the blood serum was 22.46 4.35 ng/ml, which corresponds to vitamin D insufficiency. An increase in 25(OH)D level by 3.56 ng/ml was observed after 3 months from the start of taking cholecalciferol 400 IU. After 6 months, the level of 25(OH)D reached normal values in 20% of women (p = 0.0001). In group II after childbirth, the initial level of 25(OH)D in the blood serum was 20.64 5.37 ng/ml, which corresponds to vitamin D insufficiency. An increase in 25(OH)D level by 7.60 ng/ml was observed after 3 months from the start of taking cholecalciferol 900 IU. After 6 months, the level of 25(OH)D reached normal values in 56% of women, while the average level of 25(OH)D in these women corresponded to its normally low values. The levels of PTH, calcium, phosphorus, and magnesium remained within the reference values in both groups; however, there was an increase in PTH concentration 6 months after delivery, which may indicate that the cholecalciferol dose is insufficient to stabilize PTH. Conclusion. Vitamin D deficiency and insufficiency occurred in 80-97 % of those examined after delivery. The use of prophylactic doses of cholecalciferol has a positive effect on calcium-phosphorus metabolism; however, they are not sufficient to stabilize PTH level. The cholecalciferol dose of 400 IU is insufficient to normalize the level of 25(OH)D within 6 months of administration. The cholecalciferol dose of 900 IU leads to normally low values of 25(OH)D in 56 % of women after 6 months of administration, but this does not stabilize PTH level either.

show abstract

“…Recommended by numerous committees, women, especially during the winter season, to maintain Vitamin D adequacy. Also Suggested 15-20 minutes of sunlight exposure, (Maladkar, et al, 2015). Vitamin D intoxication is an extremely rare occurrence and occurs from inadvertent or intentional vitamin D poisoning.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D3 Deficiency Among Females in Erbil City

2022

4th International Conference on Biological &Amp; Health Sciences (CIC-BIOHS’2022)

View full text Add to dashboard Cite

This study aimed to evaluate the percentage of Vitamin D deficiency in women’s in Erbil city, Kurdistan, Iraq by direct assessment and intervention, carried out in the department of nutrition and dietetics, at Cihan University, Erbil. The methods of work designed for females participants in different ages who visited health care centers and they were ready to take part in this study and filling the questionnaire, after they accepted and agree to participate then they have to do Vitamin D3 blood analysis test and depend on the result our team continue to contact with them and deliver brochures’ about Vit. D and follow up the cases one by one as much as possible especially those who had deficiency, our goal was to increase the awareness and they have to do second blood test to evaluate the progress and impact of the intervention. The main result of this study was, the percentage of deficiency more than (53%) of the participants, meanwhile many correlations was found between the health and nutritional situation and Vit. D deficiency. On the other hand, the intervention which was carried out to increase the awareness helped many females who had deficiency and accept to continue participating in the program, more than (83 %) of them they skipped the vit. D3 deficiency depend on the second blood test which was done after period between (6 - 8 weeks) only. So, we can conclude that, females in Erbil suffering from this nutrient deficiency because of many reasons, as one of the nutritional problems, and they need more and more efforts and programs to help them in their life to be in good health.

show abstract

Vitamin D Efficiency in Pregnancy: An Updated Viewpoint in Indian Scenario

Cited by 5 publications

References 85 publications

Cross-sectional study of serum parathyroid hormone level in high-risk pregnancies as compared to nonpregnant control

Cross-sectional study of serum parathyroid hormone level in high-risk pregnancies as compared to nonpregnant control

Vitamin D and mineral metabolism after childbirth with the use of preventive doses of cholecalciferol

Vitamin D3 Deficiency Among Females in Erbil City

Contact Info

Product

Resources

About