Vitamin D intake as well as circulating 25-hydroxyvitamin D level and risk for the incidence and recurrence of colorectal cancer precursors: A meta-analysis

Guo, Liliangzi; Chen, Sisi; Zhong, Lixian; He, Kaiyin; Li, Yuting; Chen, Weiwei; Zeng, Qiuting; Tang, Shaohui

doi:10.3389/fmed.2022.877275

Cited by 2 publications

(2 citation statements)

References 99 publications

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“…Up-regulated differentially metabolized species in Duroc can be annotated to KEGG_ID, such as: Saxitoxin, 4-Hydroxyphenylpyruvic acid, 12-Hydroxydodecanoic acid, Ergocalciferol, isophorone, and DL-Norvaline. Ergocalciferol (Vitamin D2) and cholecalciferol (vitamin D3) are the most common forms of vitamin D [ 34 ]. 4-hydroxyphenylpyruvic acid (4-HPPA) is a keto acid that plays a crucial role in the catabolic pathway of tyrosine [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Growth Performance and Plasma Metabolomics between Two Sire-Breeds of Pigs in China

Xie,

Gan,

et al. 2023

Genes

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The Yorkshire pigs, renowned for their remarkable growth rate, low feed conversion ratio (FCR), and high meat production, emerge as a novel preference for paternal breeding. In this study, we found that purebred paternal Yorkshire pigs (PY) surpass the purebred Duroc breed in terms of growth rate. Specifically, purebred PY attain a weight of 100 kg at an earlier age compared to purebred Duroc (Male, 145.07 vs. 162.91; Female, 145.91 vs. 167.57; p-value < 0.01). Furthermore, different hybrid combinations suggest that offspring involving purebred PY exhibit superior growth performance. Compared with purebred Duroc, the offspring of purebred PY have an earlier age in days (173.23 vs. 183.54; p-value < 0.05) at the same slaughter weight. The changes of plasma metabolites of 60-day-old purebred boars in the two sire-breeds showed that 1335 metabolites in plasma were detected. Compared with Duroc, 28 metabolites were down-regulated and 49 metabolites were up-regulated in PY. Principal component analysis (PCA) discerned notable dissimilarities in plasma metabolites between the two sire-breeds of pigs. The levels of glycerol 3-phosphate choline, cytidine, guanine, and arachidonic acid increased significantly (p-value < 0.05), exerting an impact on their growth and development. According to our results, PY could be a new paternal option as a terminal sire in three-way cross system.

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Section: Discussionmentioning

confidence: 99%

Comparison of Growth Performance and Plasma Metabolomics between Two Sire-Breeds of Pigs in China

Xie,

Gan,

et al. 2023

Genes

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“…Vitamin D (VD) is classified as a steroid hormone since it is composed of 4 cholesterol-derived molecules with a fundamental steroid composition. It is involved in several functions in the human body, such as calcium homeostasis and bone growth, as well as connecting with the parathyroid, intestine, and kidney [8,9,10]. decreased VD serum level has been linked to a higher risk of colorectal illnesses like colorectal cancer, inflammatory small intestine disease, and colon adenoma, according to epidemiological research [11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Study the Relationship between polymorphisms of Vitamin D Receptor (VDR FokI and VDR ApaI) Genes and colorectal cancer in some Iraqi population

Alwan,

Moufak,

Naji

et al. 2024

Preprint

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Background: Despite the unknown etiology of colorectal cancer (CRC), previous studies have suggested a potential contribution of genetics and environmental factors to CRC development. Therefore, investigating specific molecular pathways can provide valuable insights into CRC. This study aimed to explore the potential association between the SNP rs228570 (C/T) in the VDR FokI gene and rs7975232 (G/T) in the VDR ApaI gene with CRC. Additionally, the relationship between vitamin D levels, VDR FokI, and VDR ApaI polymorphisms was examined to evaluate the risk of colorectal cancer. Methods: The study included a total of 140 participants, with 70 individuals diagnosed with CRC and 70 healthy controls. Vitamin D serum levels were measured using the ELFA technique in both CRC patients and the healthy control group. The prevalence of mutations in the VDR FokI rs228570 (C/T) and VDR ApaI rs7975232 (G/T) genes, as well as single nucleotide polymorphisms (SNPs), were evaluated in the CRC patient and control groups using the PCR-RFLP method. Results: The results indicated a significant decrease (p < 0.05) in serum vitamin D levels in patients with colorectal cancer (CRC) compared to healthy controls. However, there was no significant difference in the genotype prevalence of VDR FokI rs228570 (C/T) and VDR ApaI rs7975232 (G/T), as well as allele frequencies between the CRC and control groups. Conclusion: The findings suggest that serum vitamin D levels could serve as potential biomarkers for CRC. However, the polymorphisms in the VDR FokI and VDR ApaI genes are not considered risk factors for CRC in Iraq. This implies that further research focusing on additional loci or VDR is necessary.

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Vitamin D intake as well as circulating 25-hydroxyvitamin D level and risk for the incidence and recurrence of colorectal cancer precursors: A meta-analysis

Cited by 2 publications

References 99 publications

Comparison of Growth Performance and Plasma Metabolomics between Two Sire-Breeds of Pigs in China

Comparison of Growth Performance and Plasma Metabolomics between Two Sire-Breeds of Pigs in China

Study the Relationship between polymorphisms of Vitamin D Receptor (VDR FokI and VDR ApaI) Genes and colorectal cancer in some Iraqi population

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