Vitamin D Level and its Relationship aith Cancer Stage in Patients with Differentiated Thyroid Carcinoma

Cocolos, A M; Vladoiu, S; Caragheorgheopol, Andra; Ghemigian, Adina; Ioachim, Dumitru; Poiană, Cătălina

doi:10.4183/aeb.2022.168

Cited by 1 publication

(1 citation statement)

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“…Kim et al found that patients in the second lowest quartile of 25(OH)D had a greater occurrence of LNM (OR 2.03, 95% CI 1.19–3.44, P = 0.009) and lateral LNM (OR 5.12, 95% CI 1.68–15.59, P = 0.009) than those in the highest quartile ( 15 ). Cocolos et al described histopathologic features of 170 patients with differentiated thyroid cancer and found patients in T stage 4 had significantly lower 25(OH)D of 10.96 ng/mL than in T stage 1 of 18.24 ng/mL, suggesting that patients with aggressive tumors had lower circulating levels of 25(OH)D ( 29 ). On the contrary, Demircioglu et al ., Kuang et al and Ahn et al showed serum 25(OH)D levels were not associated with disease aggressiveness such as LNM, tumor size, lateral LNM, or multifocality ( 16 , 17 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer

Shao,

Hu,

Wang

et al. 2023

Endocrine Connections

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Objective Serum 25-hydroxyvitamin D (25(OH)D) deficiency has been known to be associated with the risk and mortality of several cancers. However, the role of 25(OH)D in papillary thyroid cancer (PTC) remains controversial. This study aimed to investigate the association between 25(OH)D and clinicopathologic features of PTC. Methods Patients who underwent thyroidectomy were retrospectively reviewed. Serum 25(OH)D levels were measured within a week prior to surgery. The patients were categorized into four quartiles according to season-specific 25(OH)D levels. The association between 25(OH)D levels and clinicopathologic features of PTC was analyzed. Results A total of 2932 patients were enrolled in the study. The 25(OH)D levels were significantly higher in patients with lymph node metastasis (LNM; P < 0.001), lateral LNM (P < 0.001), and multifocal tumors (P < 0.001). Compared to the first quartile (Q1) of 25(OH)D level, the third quartile (Q3) and the fourth quartile (Q4) showed an unadjusted OR of 1.36 (95% CI: 1.09–1.69; P = 0.006) and 1.76 (95% CI: 1.42–2.19; P < 0.001) for LNM (P for trend < 0.001), respectively. An increased risk of multifocal tumors was strongly associated with high 25(OH)D concentration (P for trend <0.001). Similar results were obtained after adjusting for confounding factors. Conclusion High 25(OH)D levels are associated with aggressive features of PTC, such as lymph node metastasis and multifocality.

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