Vitamin D Level as a Predictor of Dysmobility Syndrome in Middle-aged and older adults with Type 2 Diabetes

Abstract

This cross-sectional study aimed to explore the effect of 25-(OH) Vit D on Dysmobility Syndrome (DMS)in type 2 diabetes mellitus(T2DM) patients, including 330 patients (66.96±8.78 years old) with T2DM who were admitted to the Qinhuangdao First Hospital from October 2020 to February 2022. The 25-(OH) Vit D is grouped at the 25th percentile into two groups (group A <36.2nmol/L, group B ≥ 36.2nmol/L). Data on grip strength, six meters grip strength, and level of 25-(OH) vitamin D were collected and measure bone mineral density (BMD) by Dual-energy X-ray (DXA). The incidence of DMS in patients with T2DM was 25.5%. The proportion of vitamin deficiency is 67.9% in patients with T2DM. Compared with patients without DMS, the level of 25-(OH)Vit D in patients with DMS was lower (41.74±14.60 vs 47.19±13.01, P＜0.05). With DMS as the dependent variable, Gender, age, vitamin D level, HbA1c, ALB, HDLC, eGFR, Diabetic retinopathy, diabetes nephropathy, and diabetes peripheral neuropathy were taken as independent variables, and logistic regression analysis was performed to find the independent factors, which include age (OR value=1.175，95%CI：1.110-1.243, P=0.000), low levels of 25-(OH) Vit D (OR value=2.910，95%CI：1.357-6.242, P=0.006), and higher levels of HbA1c(OR value=1.288, 95%CI: 1.085-1.529, P=0.004), they are associated with the risk of DMS’s prevalence in T2DM patients. But males reduce the risk of DMS by 51.3% (OR value=0.487, 95%CI: 0.238-0.998, P=0.05).