Vitamin D Level in Children with Secretory Otitis Media

Mandour, Yasser; Shendy, Mohammed; Ramadan, Safaa A; Mohammady, Ayman A; Badae, Samer

doi:10.5005/jp-journals-10003-1366

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…OM in pediatric patients is one of the most prevalent disorders with around 80% of the children below seven years of age getting infected. Similarly, OME has been shown to occur in 90% of children below four years of age [ 27 , 28 ]. Vitamin D has a positive role in strengthening the immune system.…”

Section: Reviewmentioning

confidence: 99%

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Exploring the Significance of Vitamin D Levels as a Biomarker in Ear Diseases: A Narrative Review

Hamayal,

Khurshied,

Zahid

et al. 2024

Cureus

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This narrative review examines the role of vitamin D as a biomarker in ear disorders, including benign paroxysmal positional vertigo (BPPV), otitis media, bell's palsy, Meniere's disease, and hearing loss. PubMed, The Cochrane Library, and Google Scholar were utilized to conduct a comprehensive literature search, and findings were combined from studies from 2014 to 2024. As highlighted in this review, there is a consistent association between vitamin D deficiency and an increased risk and recurrence of disease especially in BPPV and otitis media. Its importance as a prognostic biomarker is emphasized in Bell’s palsy, where higher levels of deficiencies in vitamin D are associated with higher grades of severity on the House Brackmann grading system. Vitamin D deficiency can also lead to sensorineural hearing loss due to its receptors present in the inner ear or its effect on calcium metabolism. Serum levels of vitamin D have also been shown to influence treatment outcome of sensorineural hearing loss. The role of vitamin D in Meniere's disease is unclear as no cause has been identified for the increase in endolymphatic fluid. The findings of this review emphasize the importance of serum vitamin D as a biomarker in ear disorders and advocate for more studies to be conducted to assess the importance of optimal dosing of vitamin D for the progression and outcome of these diseases.

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Section: Reviewmentioning

confidence: 99%

“…Gender-wise, females were more likely to have vitamin D deficiency associated with SOM. Furthermore, the adenoids enlarged in patients with vitamin deficiency which could further worsen the prognosis of OME [ 28 ].…”

Section: Reviewmentioning

confidence: 99%

Exploring the Significance of Vitamin D Levels as a Biomarker in Ear Diseases: A Narrative Review

Hamayal,

Khurshied,

Zahid

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

Association between vitamin D deficiency and otitis media with effusion in children: a systematic review and meta-analysis

Restuti,

Safitri,

Ranakusuma

et al. 2024

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Background Vitamin D plays a crucial role in the regulation of inflammation. However, its effect on the development of otitis media effusion (OME), an inflammatory disease of the middle ear without signs of infection, remains largely unknown. Objective To assess the association between vitamin D deficiency and OME in children by systematic review and meta-analysis of the literature. Methods Eligible studies retrieved from PubMed, ProQuest, Embase, Cochrane databases and trial registries published up to 30 October 2022 were included in this review. The risk of bias of the included articles was assessed with the JBI Critical Appraisal Checklist for observational studies. The certainty of evidence was assessed with the Grading of Recommendations Assessment, Development and Evaluation framework. Results We included eight studies (six case-control and two cross-sectional studies) involving 1,114 children, of which four studies were eligible for meta-analysis due to the significant clinical heterogeneity. We found that vitamin D deficiency (defined as vitamin D concentration of 20 ng/mL or less, i.e., ?50 nmol/L) might increase the odds of developing OME by 66.0% (n=514; OR 1.66; 95%CI 1.09 to 2.54; I2=20%), albeit with a very low certainty of evidence. Conclusion There is a very low quality of evidence indicating that vitamin D deficiency is associated with the development of OME in children. Further large, high-quality cohorts and adjusting for confounding factors are warranted to confirm our findings, ideally by exploring the dose-response relationship between vitamin D concentration and the development of OME.

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Vitamin D Level in Children with Secretory Otitis Media

Cited by 2 publications

References 33 publications

Exploring the Significance of Vitamin D Levels as a Biomarker in Ear Diseases: A Narrative Review

Exploring the Significance of Vitamin D Levels as a Biomarker in Ear Diseases: A Narrative Review

Association between vitamin D deficiency and otitis media with effusion in children: a systematic review and meta-analysis

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