Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study

Clarke, Sarah L N; Mitchell, Ruth; Sharp, Gemma C; Ramanan, Athimalaipet V; Relton, Caroline L

doi:10.1002/acr.24815

Cited by 10 publications

(4 citation statements)

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“…These studies have revealed common genetic risk loci for oligoarticular JIA, polyarticular JIA, and psoriatic JIA. [ 46 , 47 ] Mendelian randomization studies have provided insights into identifying genetically causative variants for JIA, further unraveling the mechanisms underlying JIA susceptibility and associated outcomes. Moreover, MR studies have helped in understanding racial, ethnic, and geographical variations in JIA.…”

Section: Resultsmentioning

confidence: 99%

Advancements and progress in juvenile idiopathic arthritis: A Review of pathophysiology and treatment

Huang,

Wireko,

Miteu

et al. 2024

Medicine

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Juvenile idiopathic arthritis (JIA) is a chronic clinical condition characterized by arthritic features in children under the age of 16, with at least 6 weeks of active symptoms. The etiology of JIA remains unknown, and it is associated with prolonged synovial inflammation and structural joint damage influenced by environmental and genetic factors. This review aims to enhance the understanding of JIA by comprehensively analyzing relevant literature. The focus lies on current diagnostic and therapeutic approaches and investigations into the pathoaetiologies using diverse research modalities, including in vivo animal models and large-scale genome-wide studies. We aim to elucidate the multifactorial nature of JIA with a strong focus towards genetic predilection, while proposing potential strategies to improve therapeutic outcomes and enhance diagnostic risk stratification in light of recent advancements. This review underscores the need for further research due to the idiopathic nature of JIA, its heterogeneous phenotype, and the challenges associated with biomarkers and diagnostic criteria. Ultimately, this contribution seeks to advance the knowledge and promote effective management strategies in JIA.

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Section: Resultsmentioning

confidence: 99%

Advancements and progress in juvenile idiopathic arthritis: A Review of pathophysiology and treatment

Huang,

Wireko,

Miteu

et al. 2024

Medicine

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“…Por otro lado, Yi y col en el año 2022 ( Yi Wu , et al, 2022), mencionan que existen datos mecanicistas y epidemiológicos que respaldan la importancia de la vitamina D en la promoción de la salud ósea y la modulación del estado de la enfermedad en la artritis idiopática juvenil pero que se necesitan más estudios para aclarar la eficacia de los suplementos de la vitamina D en pacientes con AIJ, mientras que Clarke y col en el año 2023 (Clarke , et al, 2023), indican que en su estudio no se encontró una relación causal entre los niveles de vitamina D y la AIJ por lo cual indican que es poco probable que la suplementación con vitamina D a nivel poblacional reduzca la incidencia de la AIJ.…”

Section: Discussionunclassified

Vitamina D y enfermedades autoinmunes reumáticas

Parrales-Ponce,

Marcillo-Castro,

Tenorio-Figueroa

et al. 2024

MQRInvestigar

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La vitamina D es importante para el funcionamiento de las inmunoreguladoras para la mejoría de las respuestas inmunes innata contra los microorganismos, la deficiencia de la vitamina D ha provocado el desarrollo de diversas debido a la baja contracción de está provocando varias enfermedades autoinmunes reumáticas. El objetivo de la investigación fue analizar la Vitamina D y su relación con las enfermedades autoinmunes reumáticas con la finalidad de proporcionar una comprensión integral de su papel en la patogénesis, con una metodología de diseño de estudio documental de tipo explicativo y bibliográfico, donde se utilizaron bases de datos como PubMed, Scielo, Dialnet, Realyc, Elsevier, Google académico. Los resultados obtenidos sobre las causas de la deficiencia de la vitamina D es la baja exposición al sol lo que puede provocar osteomalacia y raquitismo nutricional, seguido malabsorción de vitamina D, las enfermedades autoinmunes reumáticas relacionada con la vitamina D, los resultados sugieren que la deficiencia de vitamina D es frecuente en pacientes con artritis reumatoide, los métodos de diagnósticos más utilizados son Anti-CCP, TCAR, PRF, PCR, biopsia cutánea, ANA, anti DNA, ACR SLICC y ensayos ELISA. En conclusión, se logró identificar durante la investigación las diferentes enfermedades autoinmunes reumáticas que puede provocar la deficiencia de la vitamina D y como este puede afectar la vida de las personas.

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“…Instead, a study by Thorsen et al reported no association between serum 25(OH)D concentration at birth and the risk of JIA later in life [ 69 ]. Similarly, a recent Mendelian randomization study by Clarke and colleagues showed no causal relationship between serum 25(OH)D and JIA [ 70 ]. Even so, considering the immunomodulatory properties and potential immune-restoring effects of vitamin D discussed earlier, we aim to explore how it affects JIA treatment and outcomes.…”

Section: Vitamin D: Chemistry Metabolism Optimal Serum Concentration ...mentioning

confidence: 99%

“…Lower UVR exposure may increase JIA risk Thorsen et al (2017) [ 69 ] Case–control No significant association was found between 25(OH)D levels and the risk of JIA. No evidence that 25(OH)D levels around birth are linked to later JIA risk Clarke et al (2023) [ 70 ] Mendelian randomization No evidence indicating a causal relationship between genetically predicted 25(OH)D levels and the incidence of JIA. Lack of evidence suggesting that genetically predicted JIA causally affects 25(OH)D levels Nandi et al (2022) [ 72 ] Observational A significant negative correlation between the JADAS-27 score and serum vitamin D was confirmed.…”

Section: Vitamin D: Chemistry Metabolism Optimal Serum Concentration ...mentioning

confidence: 99%

Can vitamin D be an adjuvant therapy for juvenile rheumatic diseases?

et al. 2023

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Vitamin D, known for its essential role in calcium and bone homeostasis, has multiple effects beyond the skeleton, including regulation of immunity and modulation of autoimmune processes. Several reports have shown suboptimal serum 25 hydroxyvitamin D [25(OH)D] levels in people with different inflammatory and autoimmune rheumatic conditions, and an association between 25(OH)D levels, disease activity and outcomes. Although most available data pertain to adults, insights often are extended to children. Juvenile rheumatic diseases (JRDs) are a significant health problem during growth because of their complex pathogenesis, chronic nature, multisystemic involvement, and long-term consequences. So far, there is no definitive or clear evidence to confirm the preventive or therapeutic effect of vitamin D supplementation in JRDs, because results from randomized controlled trials (RCTs) have produced inconsistent outcomes. This review aims to explore and discuss the potential role of vitamin D in treating selected JRDs. Medline/PubMed, EMBASE, and Scopus were comprehensively searched in June 2023 for any study on vitamin D supplementary role in treating the most common JRDs. We used the following keywords: “vitamin D” combined with the terms “juvenile idiopathic arthritis”, “juvenile systemic scleroderma”, “juvenile systemic lupus erythematosus”, “juvenile inflammatory myopathies”, “Behcet disease”, “periodic fever syndromes” and “juvenile rheumatic diseases”. Observational studies have found that serum 25(OH)D concentrations are lower in juvenile idiopathic arthritis, juvenile systemic lupus erythematosus, juvenile systemic scleroderma, Behcet disease and proinflammatory cytokine concentrations are higher. This suggests that vitamin D supplementation might be beneficial, however, current data are insufficient to confirm definitively the complementary role of vitamin D in the treatment of JRDs. Considering the high prevalence of vitamin D deficiency worldwide, children and adolescents should be encouraged to supplement vitamin D according to current recommendations. More interventional studies, especially well-designed RCTs, assessing the dose–response effect and adjuvant effect in specific diseases, are needed to determine the potential significance of vitamin D in JRDs treatment.

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Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 10 publications

References 42 publications

Advancements and progress in juvenile idiopathic arthritis: A Review of pathophysiology and treatment

Advancements and progress in juvenile idiopathic arthritis: A Review of pathophysiology and treatment

Vitamina D y enfermedades autoinmunes reumáticas

Can vitamin D be an adjuvant therapy for juvenile rheumatic diseases?

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